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001-es BibID:	BIBFORM051308
Első szerző:	Dezső Balázs (pathológus)
Cím:	Insights into the mechanisms of local tumor irradiation combined with IL-2 therapy in metastatic murine renal carcinoma : immunohistochemical analysis of tumor sites / Balazs Dezsö, Gilda G. Hillman, Sue Kim, Emily J. Montecillo, Fasahat Hamzavi, Philip D. Benson, Richard Maughan, J. Edson Pontes, Gabriel P. Haas
Dátum:	1995
ISSN:	0250-7005
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt kidney carcinoma IL-2 therapy irradiation
Megjelenés:	Anticancer Research. - 15 : 5A (1995), p. 1740. -
További szerzők:	Hillman, Gilda G. Kim, Sue Montecillo, Emily J. Hamzavi, Fasahat Benson, Philip D. Maughan, Richard L. Pontes, J. Edson Haas, Gabriel P.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM024680
Első szerző:	Nagy András (pathológus)
Cím:	Copy number of cancer genes predict tumor grade and survival of pancreatic cancer patients / Andras Nagy, Laszlo Kozma, Istvan Kiss, Istvan Ember, Istvan Takacs, Jeno Hajdu, Nadir R. Farid
Dátum:	2001
ISSN:	0250-7005
Megjegyzések:	Pancreatic cancer is on the increase. While means of early diagnosis are being sought, it continues to present late. Prognostication is based on patient and tumor characteristics, including expression or mutation of cancer-related genes. Few studies have examined the impact of the amplification of these genes on the outcome of pancreatic cancer. We have now used a non-radioisotopic slot-blot technique to relate gene copy numbers of p53, c-myc and K-ras to tumor grade and survival. Outcomes were corrected for patient characteristics, tumor location and TNM staging. The Kaplan-Meier test for likelihood of survival showed that increase in copy number of the two oncogenes and loss of p53 were associated with non-significant reduction in survival. When these variations in cancer gene copy numbers were, however, examined by logistic regression analysis in the context of patient and tumor characteristics, survival was negatively related to K-ras amplification (p = 0.0291). Tumor grade, but not survival was positively related to loss of p53 gene copy (p = 0.0131) as well as c-myc amplification (p = 0.0248). Thus using a simple non-radioisotopic technique for the detection of cancer gene copy number in association with patients and disease characteristics, we could predict survival on the one hand and tumor behavior on the other. Such information could be used to plan initial and follow-up therapy.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Anticancer Research. - 21 : 2B (2001), p. 1321-1325. -
További szerzők:	Kozma László (orvos) Kiss István (Pécs) Ember István Takács István (1963-) (sebész) Hajdu Jenő Farid, Nadir R.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM071230
Első szerző:	Virga József
Cím:	Differences in Extracellular Matrix Composition and its Role in Invasion in Primary and Secondary Intracerebral Malignancies / Virga J., Szemcsák C. D., Reményi-Puskár J., Tóth J., Hortobágyi T., Csősz É., Zahuczky G., Szivos L., Bognár L., Klekner A.
Dátum:	2017
ISSN:	0250-7005 1791-7530
Megjegyzések:	1. Anticancer Res. 2017 Aug;37(8):4119-4126.Differences in Extracellular Matrix Composition and its Role in Invasion inPrimary and Secondary Intracerebral Malignancies.Virga J(1), Szemcsák CD(1), Reményi-Puskár J(1), Tóth J(2), Hortobágyi T(3),Csősz É(4), Zahuczky G(5), Szivos L(1), Bognár L(1), Klekner A(6).Author information: (1)Department of Neurosurgery, Clinical Centre, University of Debrecen, Debrecen,Hungary.(2)Department of Oncology, Clinical Centre, University of Debrecen, Debrecen,Hungary.(3)Department of Neuropathology, Institute of Pathology, MTA-DE Cerebrovascularand Neurodegenerative Research Group, University of Debrecen, Debrecen, Hungary.(4)Proteomics Core Facility, Department of Biochemistry and Molecular Biology,Faculty of Medicine, University of Debrecen, Debrecen, Hungary.(5)UD-GenoMed Medical Genomic Technologies Research & Development Services Ltd., Debrecen, Hungary.(6)Department of Neurosurgery, Clinical Centre, University of Debrecen, Debrecen,Hungary neurosurgery.debrecen@freemail.hu.BACKGROUND/AIM: The most common malignant primary brain tumor is glioblastomawhich infiltrates the peritumoral brain, while secondary brain metastases arewell demarcated malignancies. Previous research has proved the pivotal role ofthe changes in the extracellular matrix (ECM) in cancer cell invasion.MATERIALS AND METHODS: The mRNA expression of 40 ECM molecules was determinedusing qRT-PCR in 54 fresh-frozen glioblastoma and brain metastasis samples.Seventy-two samples were used to determine the levels of 20 ECM proteins.RESULTS: The mRNA and protein expression pattern of the studied tumors differsgreatly. Linear discriminant analysis of mRNA expression identified samples basedon their mRNA expression profile with 92.3% probability and highlighted the role of some molecules as their level greatly influenced sample identification.CONCLUSION: Different tumor types with different invasiveness differ in thecomposition of their ECM and this can be used to identify samples. Furthermore,some ECM molecules greatly contribute to tumor invasiveness and could be targets of anti-invasive oncotherapy.Copyright? 2017, International Institute of Anticancer Research (Dr. George J.Delinasios), All rights reserved.DOI: 10.21873/anticanres.11799 PMID: 28739696 [Indexed for MEDLINE]
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Anticancer Research 37 : 8 (2017), p. 4119-4126. -
További szerzők:	Szemcsák Csaba D. Reményi-Puskár Judit Tóth Judit (1958-) (onkológus szakorvos) Hortobágyi Tibor (1965-) (patológus) Csősz Éva (1977-) (biokémikus, molekuláris biológus) Zahuczky Gábor (1975-) (molekuláris biológus, biokémikus, vegyész) Szivos László (1993-) (idegsebész) Bognár László (1958-) (idegsebész, gyermekidegsebész) Klekner Álmos (1970-) (idegsebész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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