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001-es BibID:	BIBFORM009099
Első szerző:	Czifra Gabriella (élettanász)
Cím:	Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma / Czifra, G., Varga, A., Nyeste, K., Marincsak, R., Toth, B. I., Kovacs, I., Kovacs, L., Biro, T.
Dátum:	2009
ISSN:	0171-5216
Megjegyzések:	Recently, functional cannabinoid receptor-1 (CB1) and vanilloid receptor-1 (TRPV1) have been described in human prostate and prostate cancer-derived cell lines where the activation of the receptors resulted in inhibition of cellular growth. We, however, lack the description of the expression of these molecules in human prostate cancer (PCC) and in benign prostate hyperplasia (BPH). METHODS: Therefore, immunohistochemistry, Western blotting, and quantitative "real-time Q-PCR were performed to define the expressions of CB1 and TRPV1 in healthy and diseased prostate tissues. RESULTS: CB1 was identified in epithelial and smooth muscle cells types of the human prostate, whereas TRPV1 was exclusively localized to the mucosal cells. We also found that the expression of CB1 and TRPV1 (both at the protein and mRNA levels) were significantly up-regulated in PCC. However, while the increased expression of TRPV1 showed a proper correlation with increasing PCC tumor grades, such phenomenon was not observed with CB1. In addition, we also measured markedly elevated CB1 levels in BPH tissues whilst the expression of TRPV1 was not altered when compared to healthy control prostate. CONCLUSIONS: Our findings strongly argue for that (1) the CB1 and TRPV1 molecules as well as their ligands may indeed possess a promising future role in the treatment of PCC; (2) TRPV1 may also serve as a prognostic factor in PCC; and (3) CB1 may act as a potential target molecule in the therapeutic management of BPH.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Cancer Research and Clinical Oncology. - 135 : 4 (2009), p. 507-514. -
További szerzők:	Varga Attila (1949-) (urológus, andrológus) Nyeste Katalin Marincsák Rita (1979-) (fogszakorvos) Tóth István Balázs (1978-) (élettanász) Kovács Ilona (1965-) (patológus) Kovács László (1939-) (élettanász) Bíró Tamás (1968-) (élettanász)
Internet cím:	DOI elektronikus változat elektronikus változat
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001-es BibID:	BIBFORM055417
Első szerző:	Dezső Balázs (pathológus)
Cím:	Morphological and immunohistochemical characteristics of dimethylnitrosamine-induced malignant mesenchymal renal tumor in F-344 rats / B. Dezso, P. Rady, I. Morocz, E. Varga, Sz. Gomba, K. Poulsen, P. Kertai
Dátum:	1990
ISSN:	0171-5216
Megjegyzések:	Mesenchymal renal tumors in F-344 newborn rats were induced by a single dose of dimethylnitrosamine. The induced tumors were successfully transplanted into adult rats under the renal capsule. Neither the primary nor the transplanted neoplasms from various generations of grafts changed their morphological features during the tumor passage, having the same cellularity with high mitotic activity and the tendency to invade the host kidney rapidly. On the basis of lectin histochemistry and immunohistology, the tumor proved to be a mesenchymal neoplasm without any obvious capacity of the proliferating cells to differentiate into any well-known organoid element normally found in mature renal parenchyma. However, the proliferating neoplastic cells were found to have a strong vimentin positivity with desmin expression. Ultrastructurally, myofilaments with attachment bodies characteristic of smooth muscle cells were generally present in various amounts in many tumor cells. In addition, on the basis of the physiological data and on kidney/tumor renin activity obtained, it is interesting to note that the tumor-graft-invaded kidneys retained their enzyme activity, despite the obvious loss of renal tissue including glomeruli. However, the immunohistochemical findings with anti-renin antibody have clearly shown that this is not due to a renin-producing tumor but rather to the surviving (probably) non-neoplastic arterioles retaining the capacity to produce renin. Although these arterioles have mostly been found next to necrotic areas, commonly occurring in dimethylnitrosamine-induced transplantable renal tumors, the question of a possible physiological role of renin in tumor necrosis or in angiogenesis has remained open.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Cancer Research and Clinical Oncology. - 116 : 4 (1990), p. 372-378. -
További szerzők:	Rády Péter Mórocz István Varga E. Gomba Szabolcs (1933-2016) (pathológus) Poulsen, Knud Kertai Pál (1927-2016) (népegészségügyi szakember)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM002773
Első szerző:	Tsakiris, Ioannis (orvos)
Cím:	The presence of carboxypeptidase-M in tumour cells signifies epidermal growth factor receptor expression in lung adenocarcinomas : the coexistence predicts a poor prognosis regardless of EGFR levels / Tsakiris I., Soos G., Nemes Z., Sz. Kiss S., Andras C., Szantó J., Dezso B.
Dátum:	2008
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Cancer Research and Clinical Oncology. - 134 : 4 (2008), p. 439-451. -
További szerzők:	Soós Györgyike (1959-) (pathológus) Nemes Zoltán (1942-) (patológus) Kiss Sándor, Sz. (1946-) (sebész) András Csilla (1961-) (onkológus szakorvos) Szántó János (1949-) (onkológus szakorvos) Dezső Balázs (1951-) (pathológus)
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