Találati lista | Tudóstér

001-es BibID:	BIBFORM072861
Első szerző:	Majai Gyöngyike (belgyógyász, immunológus)
Cím:	Orbital Pseudotumor : a Rare Variant of Granulomatosis with Polyangiitis / Majai G., Tarjan P., Dezso B., Zeher M.
Dátum:	2015
Megjegyzések:	Granulomatosis with Polyangiitis (GPA) is an autoimmune small vessel vasculitis with unknown aetiology, characterized by necrotizing granulomatous inflammation affecting the renal, pulmonary, upper airways and ocular systems and is often associated with circulating Anti-Neutrophil Cytoplasmic Antibodies (ANCA) against proteinase 3.Here we report a presentation of GPA showing orbital involvement (without systemic involvement) with the classical histological triad, and also significant localized tissue eosinophilia which corresponds with the rare eosinophilic form of GPA. This variant of GPA should be differentiated from Eosinophilic Granulomatosis with Polyangiitis (EGPA); and the differential diagnosis between the two entities, and also the treatment of GPA is discussed.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Orbital pseudotumor Eosinophilic variants of GPA Small vessel vasculitis Anti-CD20 monoclonal antibody therapy
Megjelenés:	Austin Journal of Clinical Immunology. - 2 : 1 (2015), p. 1-3. -
További szerzők:	Tarján Péter Dezső Balázs (1951-) (pathológus) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM002477
Első szerző:	Molnár Ildikó (belgyógyász, endokrin, immun- és allergológiai szakorvos)
Cím:	Immunohistochemical studies using immunized Guinea Pig sera with features of anti-human thyroid, eye and skeletal antibody and graves sera / Ildikó Molnár, Zita Szombathy, Ilona Kovács, József Szentmiklósi
Dátum:	2007
Megjegyzések:	Type 2 5' deiodinase enzyme was observed in both thyroid and eye muscle tissues, highlighting its possible role as a common antigen in thyroid-associated ophthalmopathy. Sera of 105 Graves' patients and 40 controls, and immunized guinea pig sera against TCSS peptide, showing homology to the amino acid sequence from 132 to 152 of type 2 5' deiodinase, were investigated to demonstrate the binding effects to human thyroid, eye and skeletal muscle tissues. Twenty-two Graves' patients were positive for anti-TCSS peptide antibodies, of whom 18 cases had ophthalmopathy. The levels of anti-TCSS peptide antibodies were higher not only in Graves' patients with (P<0.0001) and without (P<0.036) eye symptoms compared to controls but also the difference was significant between patients with and without ophthalmopathy (P<0.049). In Western blot, immunized sera showed binding reactions to the supernatant fractions of human thyroid, eye and skeletal muscle tissues at the range of 29 kDa. Patient sera with Graves' ophthalmopathy resulted in positive reactions directed to membrane areas in thyroid follicular cells, and to fibers in eye and skeletal muscles using immunohistochemical method, while no positive staining was present after adding control sera. The binding features of immunized guinea pig sera exhibited similar staining in all human tissues but could be blocked with Graves' sera. Our results suggest that type 2 5' deiodinase enzyme protein could play a role as an antigen in Graves' disease. Immunized guinea pig sera against TCSS
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Type 2 5' deiodinase Graves' ophthalmopathy antibodies
Megjelenés:	Journal of Clinical Immunology. - 27 : 2 (2007), p. 172-180. -
További szerzők:	Szombathy Zita Kovács Ilona (1965-) (patológus) Szentmiklósi József András (1948-) (farmakológus, klinikai laboratóriumi szakorvos)
Internet cím:	elektronikus változat DOI
Borító:
Saját polcon: