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1.

001-es BibID:BIBFORM029711
Első szerző:Blasberg, Ronald
Cím:Application of quantitative autoradiographic measurements in experimental brain tumor models / Blasberg R. G., Groothuis D. R., Molnar P.
Dátum:1981
ISSN:0271-8235
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Seminars In Neurology. - 1 : 3 (1981), p. 203-221. -
További szerzők:Groothuis, Dennis Molnár Péter Pál (1951-) (pathológus)
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2.

001-es BibID:BIBFORM029710
Első szerző:Blasberg, Ronald
Cím:Regional blood flow in ethylnitrosourea-induced brain tumors / Blasberg Ronald G., Kobayashi Tomowo, Horowitz Marc, Rice J. M., Groothuis Dennis, Molnar Peter, Fenstermacher Joseph D.
Dátum:1983
ISSN:0364-5134
Megjegyzések:Regional blood flow was measured in experimental brain tumors using iodoantipyrine labeled with carbon 14 and quantitative autoradiography. A total of fifteen oligodendrogliomas, sixteen mixed gliomas, one astrocytoma, one ependymoma, and three malignant schwannomas were studied in 9 rats. The mean tumor blood flows for all glioma classifications were similar, averaging 45 +/- 3 (standard error of the mean) ml . hg-1 . min-1. Flow was fairly uniform within individual oligodendrogliomas and there was no apparent correlation between blood flow and tumor size or location. The mixed gliomas were larger than the oligodendrogliomas and had a wider range of blood flow. Small focal areas of necrosis were observed in 7 mixed gliomas, and low flows were usually measured in these regions; these flows were not always the lowest regional values measured within the mixed gliomas or total group of tumors, however. Small tumor regions with increased vascularity, frequently with endothelial cell proliferation, were observed in oligodendrogliomas and to a greater extent in mixed gliomas; these regions were correlated with small elevations in blood flow (10 to 15 ml . hg-1 . min-1) in comparison with surrounding tumor tissue. Brain adjacent to tumor usually had higher blood flows than that in tumor periphery. Hemispheric differences in blood flow related to the site of primary tumor growth were not observed.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Annals Of Neurology. - 14 : 2 (1983), p. 189-201. -
További szerzők:Kobayashi, Tomowo Horowitz, Marc Rice, Jerry M. Groothuis, Dennis Molnár Péter Pál (1951-) (pathológus) Fenstermacher, Joseph D.
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3.

001-es BibID:BIBFORM029709
Első szerző:Blasberg, Ronald
Cím:Regional blood-to-tissue transport in ethylnitrosourea-induced brain tumors / Blasberg R. G., Kobayashi T., Horowitz M., Rice J. M., Groothuis D., Molnar P., Fenstermacher J. D.
Dátum:1983
ISSN:0364-5134
Megjegyzések:Regional blood-to-tissue transport, expressed as a unidirectional transfer rate constant (K), was measured in experimental brain tumors using alpha-aminoisobutyric acid (AIB) labeled with carbon 14 and quantitative autoradiography. A total of sixteen oligodendrogliomas, four mixed gliomas, three astrocytomas, two diffuse gliomatosis, one anaplastic astrocytoma, one ependymoma and four malignant schwannomas were studied in 9 rats. The mean Ks for all glioma classifications were similar, averaging 2.6 +/- 0.4 (standard error of the mean) ml . kg-1 . min-1, and were only slightly higher than those for nontumorous parietal cortex (2.1 ml . kg-1 . min-1), corpus callosum (0.9 ml . kg-1 . min-1), and a comparable region of brain tissue in the contralateral hemisphere (1.3 ml . kg-1 . min-1). Values of K varied minimally in the intracerebral gliomas and were marginally correlated with tumor cell morphology in only two tumors. In some (but not all) of the larger gliomas, increased vascularity, with or without endothelial proliferation, was associated with a 3- to 15-fold increase in K. Regional K values in malignant schwannomas were highly variable (4 to 207 ml . kg-1 . min-1) and generally were not correlated with specific histological features of the tumor, except in some regions with increased vascularity. Estimates of the average fractional extraction of AIB by the intracranial gliomas and malignant schwannomas were 0.01 and 0.2, respectively; average fractional extractions for nontumorous brain were approximately 0.003.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Annals Of Neurology. - 14 : 2 (1983), p. 202-215. -
További szerzők:Kobayashi, Tomowo Horowitz, Marc Rice, Jerry M. Groothuis, Dennis Molnár Péter Pál (1951-) (pathológus) Fenstermacher, Joseph D.
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4.

001-es BibID:BIBFORM063677
Első szerző:Gajda Anna
Cím:Nemaline Myopathy Type 2 (NEM2): Two Novel Mutations in the Nebulin (NEB) Gene / Anna Gajda, Emese Horváth, Tibor Hortobágyi, Gyurgyinka Gergev, Hajnalka Szabó, Katalin Farkas, Nikoletta Nagy, Márta Széll, László Sztriha
Dátum:2013
ISSN:0883-0738
Megjegyzések:Nemaline myopathy is a type of the heterogeneous group of congenital myopathies. Generalized hypotonia, weakness, anddelayed motor development are the main clinical features of the typical congenital form. Histopathology shows characteristicnemaline rods in the muscle biopsy. Mutations in at least 7 genes, including nebulin gene (NEB), proved to be responsible for thismuscle disease. We present a boy with nemaline myopathy type 2 (NEM2) caused by compound heterozygosity for 2 novelmutations, a deletion and a duplication in the NEB gene. The deletion was inherited from the father and the duplication from themother. Testing all family members supports genetic counseling.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
congenital myopathy
hypotonia
nebulin
Megjelenés:Journal Of Child Neurology. - 30 : 5 (2013), p. 627-630. -
További szerzők:Horváth Emese Hortobágyi Tibor (1965-) (patológus) Gergev, Gyurgyinka Szabó Hajnalka Farkas Katalin Nagy Nikoletta Széll Márta Sztriha László
Pályázati támogatás:TA? MOP-4.2.2.A-11/1/KONV-2012-0035
Egyéb
TA? MOP-4.2.2/ B-10/1/KONV 2010-0012
Egyéb
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5.

001-es BibID:BIBFORM029685
Első szerző:Groothuis, Dennis
Cím:Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors / Groothuis D., Blasberg R. G., Molnár P., Bigner D., Fenstermacher J. D.
Dátum:1983
ISSN:0340-5354
Megjegyzések:Regional blood flow (F) was measured in avian sarcoma virus (ASV)-induced brain tumors in rats. Blood flow was variable in individual as well as different tumors; tumor F did not correlate with histologic classification, tumor size, central versus peripheral tumor regions, intraparenchymal location, cell density, or specific cytologic characteristics. Low values of F did correlate with tumor necrosis and hydrocephalus; high values of F correlated with tumorous invasion or association with choroid plexus. Mean tumor F was not significantly different from that of the same anatomic, tumor-free brain region of the contralateral hemisphere, but F in brain tissue adjacent to the tumor was depressed significantly. Depression of F was observed in tumor-free cortex and corpus callosum, especially in the hemisphere ipsilateral to the main tumor mass and in those animals with hydrocephalus.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neurology. - 33 : 6 (1983), p. 686-696. -
További szerzők:Blasberg, Ronald Molnár Péter Pál (1951-) (pathológus) Bigner, Darell Fenstermacher, Joseph D.
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6.

001-es BibID:BIBFORM100632
035-os BibID:(WoS)000749728700001 (Scopus)85133102762
Első szerző:Hudák Lilla
Cím:Discrepancies between clinical and autopsy findings in patients who had an acute stroke / Hudák Lilla, Nagy Attila Csaba, Molnár Sarolta, Méhes Gábor, Nagy Katalin Erzsébet, Oláh László, Csiba László
Dátum:2022
ISSN:2059-8688 2059-8696
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Stroke and Vascular Neurology. - 7 : 3 (2022), p. 215-221. -
További szerzők:Nagy Attila Csaba (1981-) (megelőző orvostan és népegészségtan szakorvos, epidemiológus) Deliné Molnár Sarolta (1990-) (patológus) Méhes Gábor (1966-) (patológus) Nagy Katalin (orvos) Oláh László (1967-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter)
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7.

001-es BibID:BIBFORM069028
Első szerző:Kovács G. Gábor
Cím:Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG) / Gabor G. Kovacs, Sharon X. Xie, Edward B. Lee, John L. Robinson, Carrie Caswell, David J. Irwin, Jon B. Toledo, Victoria E. Johnson, Douglas H. Smith, Irina Alafuzoff, Johannes Attems, Janos Bencze, Kevin F. Bieniek, Eileen H. Bigio, Istvan Bodi, Herbert Budka, Dennis W. Dickson, Brittany N. Dugger, Charles Duyckaerts, Isidro Ferrer, Shelley L. Forrest, Ellen Gelpi, Stephen M. Gentleman, Giorgio Giaccone, Lea T. Grinberg, Glenda M. Halliday, Kimmo J. Hatanpaa, Patrick R. Hof, Monika Hofer, Tibor Hortobágyi, James W. Ironside, Andrew King, Julia Kofler, Enikö Kövari, Jillian J. Kril, Seth Love, Ian R. Mackenzie, Qinwen Mao, Radoslav Matej, Catriona McLean, David G. Munoz, Melissa E. Murray, Janna Neltner, Peter T. Nelson, Diane Ritchie, Roberta D. Rodriguez, Zdenek Rohan, Annemieke Rozemuller, Kenji Sakai, Christian Schultz, Danielle Seilhean, Vanessa Smith, Pawel Tacik, Hitoshi Takahashi, Masaki Takao, Dietmar Rudolf Thal, Serge Weis, Stephen B. Wharton, Charles L. White III, John M. Woulfe, Masahito Yamada, John Q. Trojanowski
Dátum:2017
Megjegyzések:Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish ARTAG from other main types of astroglial tau pathologies related to primary frontotemporal lobar degeneration-related tauopathies we evaluated how consistently neuropathologists recognize i) different astroglial tau immunoreactivities including those of ARTAG and those associated with primary tauopathies (study 1); ii) ARTAG subtypes (study 2A); and iii) the severity of ARTAG (study 2B). Microphotographs and scanned sections immunostained for AT8 tau were made available for download and preview. Percentage (%) of agreement and kappa values with 95% confidence interval (CI) were calculated for each evaluation. The overall agreement for study 1 was > 60% with a kappa value of 0.54 (95% CI 0.433-0.645). Moderate agreement (> 90%, kappa: 0.48, 95% CI 0.457-0.900) was reached in study 2A for the identification of ARTAG pathology for each ARTAG subtype (kappa: 0.37-0.71), whereas fair agreement (kappa: 0.39, 95% CI 0.341-0.445) was reached for the evaluation of ARTAG severity. The overall assessment of ARTAG showed moderate agreement (kappa: 0.59, 95% CI 0.534-0.653) between raters. Our study supports the application of the current harmonized evaluation strategy of ARTAG with a slight modification of the evaluation of its severity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
aging
ARTAG
tau-astrogliopathy
digital pathology
interrater agreement
tau
neuropathology
Megjelenés:Journal of Neuropathology & Experimental Neurology 76 : 7 (2017), p. 605-619. -
További szerzők:Xie, Sharon X. Lee, Edward B. Robinson, John L. Caswell, Carrie Irwin, David J. Toledo, Jon B. Johnson, Victoria E. Smith, Douglas H. Alafuzoff, Irina Attems, Johannes Bencze János (1991-) (orvos) Bieniek, Kevin F. Bigio, Eileen H. Bódi István (1967-) (neuropatológus) Budka, Herbert Dickson, Dennis W. Dugger, Brittany N. Duyckaerts, Charles Ferrer, Isidro Forrest, Shelley L. Gelpi, Ellen Gentleman, Stephen Giaccone, Giorgio Grinberg, Lea T. Halliday, Glenda Hatanpaa, Kimmo J. Hof, Patrick R. Hofer, Monika Hortobágyi Tibor (1965-) (patológus) Ironside, James W. King, Andrew Kofler, Julia Kővári Enikő Kril, Jillian J. Love, Seth Mackenzie, Ian R. Mao, Qinwen Matej, Radoslav McLean, Catriona Munoz, David G. Murray, Melissa E. Neltner, Janna Nelson, Peter T. Ritchie, Diane Rodriguez, Roberta D. Rohan, Zdenek Rozemuller, Annemieke Sakai, Kenji Schultz, Christian Seilhean, Danielle Smith, Vanessa Tacik, Pawel Takahashi, Hitoshi Takao, Masaki Thal, Dietmar R. Weis, Serge Wharton, Stephen B. White III, Charles L. Woulfe, John M. Yamada, Masahito Trojanowski, John Q.
Pályázati támogatás:NAP_KTIA_13_NAP-A-II/7
MTA
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8.

001-es BibID:BIBFORM055459
Első szerző:Molnár Péter Pál (pathológus)
Cím:Primary Intracranial eosinophilic chloroma (EMT) / P. P. Molnár, T. Németh, L. Rejtő, B. Telek, Gy. Csécsei
Dátum:2001
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Journal of Neuropathology and Experimental Neurology. - 60 (2001), p. 451. -
További szerzők:Németh Tamás (patológus) Rejtő László (1963-) (belgyógyász, haematológus) Telek Béla (1948-) (belgyógyász, haematológus) Csécsei György (1948-2005) (idegsebész)
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9.

001-es BibID:BIBFORM055311
Első szerző:Molnár Péter Pál (pathológus)
Cím:Adjacent astrocytoma and ependymoma : dependent mixed neoplasia or unusual collision tumors? / Péter Molnár, Katalin Hegedüs
Dátum:1984
ISSN:0090-3019
Megjegyzések:Concurrent neoplastic transformation of different cellular elements resulting in an intraventricular and intraparenchymal tumor is described. An infiltrating astrocytoma of the left frontal lobe had been partially removed from a 43-yr-old woman. Four months later she died, and the autopsy revealed a recurrent astrocytoma and a closely apposed large intraventricular ependymoma. Both light microscopy and ultrastructural findings established the different nature of the two tumors. Theoretically they could represent collision or composite tumors. Another possibility would be that a relatively longstanding ependymoma induced the astrocytic neoplasm. The clinical history and the sequential morphological analysis, i.e., biopsy and autopsy sampling suggest that the ependymoma developed due to the inductive influence of the astrocytic growth.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Surgical Neurology. - 22 : 5 (1984), p. 455-460. -
További szerzők:Hegedűs Katalin (1946-2017) (ideggyógyász, neuropathológus)
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10.

001-es BibID:BIBFORM029686
Első szerző:Molnár Péter Pál (pathológus)
Cím:Regional blood-to-tissue transport in avian sarcoma virus (ASV)-induced brain tumors / Molnar P., Blasberg R. G., Groothuis D., Bigner D., Fenstermacher J. D.
Dátum:1983
ISSN:0340-5354
Megjegyzések:Regional blood-to-tissue transport of 14C-alpha-aminoisobutyric acid (AIB) was measured in avian sarcoma virus (ASV)-induced rat brain tumors and expressed as a unidirectional transfer rate constant (K). The magnitude of K was variable and did not correlate with histologic classification or specific features of the tumors, with the possible exception of sarcomas. Averaged mean K was highest for anaplastic astrocytomas and lowest for gemistocytic astrocytomas (GA); however, the range of measurement within the individual tumor classifications (except GA) was broad. K was not consistently related to tumor size or tumor location; choroid plexus and subependymal tumors were exceptions and had higher K values. The averaged mean K of tumor-free brain in the contralateral hemisphere (CBA) was comparable to that of control animals. The averaged mean K in brain adjacent to tumor was greater than in CBA and generally one-third to one-half of the value in tumor periphery, indicating that these tumors affect the permeability characteristics of adjacent brain capillaries. Estimates of the fractional extraction (E) of AIB by the tumors ranged between 0.009 and 0.2; E's in this range indicate that tumor capillaries are not freely permeable to this solute.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neurology. - 33 : 6 (1983), p. 702-711. -
További szerzők:Blasberg, Ronald Groothuis, Dennis Bigner, Darell Fenstermacher, Joseph D.
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11.

001-es BibID:BIBFORM040698
Első szerző:Novák László (idegsebész)
Cím:Does increased 18FDG uptake reflect malignant transformation of a low-grade glioma? : a diagnostic dilemma / Novák, L., Molnar, P., Lengyel, Z., Tron, L.
Dátum:2005
ISSN:0028-3886
Megjegyzések:Benign gliomas of the brain show decreased uptake of 18F fluorodeoxyglucose (FDG) on positron emission tomography (PET). Malignant transformation is usually manifested by an increase of 18FDG uptake. A 45-year-old female has been followed up since 1987 by means of 18FDG-PET for a right hemispheric World Health Organization Grade II oligoastrocytoma. In 1996, increased epileptic activity was accompanied by increased 18FDG uptake within the temporal part of the tumor. After surgery, the epileptic seizures diminished. Histological examination of the resected tumor showed no change in the pathology when compared with the first biopsy. Localized temporal increase of 18FDG uptake was not associated with malignant progression. The decrease of seizure frequency might shed light on a putative connection of hyperglycolysis and epileptic discharges.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Neurology India. - 53 : 1 (2005), p. 112-114. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Lengyel Zsolt (nukleáris medicina szakorvos) Trón Lajos (1941-) (biofizikus)
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12.

001-es BibID:BIBFORM063679
Első szerző:Peters, Owen M.
Cím:Gamma-synuclein pathology in amyotrophic lateral sclerosis / Owen M. Peters, Tatyana Shelkovnikova, John Robin Highley, Johnathan Cooper-Knock, Tibor Hortobagyi, Claire Troakes, Natalia Ninkina1, Vladimir L. Buchman
Dátum:2015
ISSN:2328-9503
Megjegyzések:sclerosis (ALS) is the presence of intracellular inclusions in degenerating neuronsand their axons. The appearance and localization of these pathologicalstructures depend on an aggregated protein that forms their scaffold. We investigatedif c-synuclein, an aggregation-prone protein highly expressed in healthymotor neurons, and predominantly localized in their axons and synaptic terminalsis involved in ALS pathology. Methods: Immunostaining of histologicalsections and sequential protein extraction from postmortem neural samplesfollowed by immunoblotting. Results: Immunohistochemical screening revealeda subset of sporadic (9 of 31) and familial (8 of 23) ALS cases with a novel typeof pathology characterized by the accumulation of c-synuclein in distinctprofiles within the dorsolateral column. Sequential fractionation of proteinsfrom the spinal cord tissues revealed detergent-insoluble c-synuclein speciesspecifically in the dorsolateral corticospinal tracts of a ALS patient withc-synuclein-positive profiles in this region. These profiles are negative for proteinmarkers commonly found in pathological inclusions in the spinal cord ofALS patients and most probably represent degenerated axons of upper motorneurons that have lost their neurofilaments. A subset of these profiles wasfound in association with phagocytic cells positive for Mac-2/Galectin-3. Asmaller subset of studied ALS cases (4 of 54) contained large cytoplasmic inclusionsin the cell body of remaining spinal motor neurons. Interpretation: Ourobservations suggest that pathological aggregation of c-synuclein might contributeto the pathogenesis of ALS.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Annals of Clinical and Translational Neurology. - 2 : 1 (2015), p. 29-37. -
További szerzők:Shelkovnikova, Tatyana Highley, John Robin Cooper-Knock, Johnathan Hortobágyi Tibor (1965-) (patológus) Troakes, Claire Ninkina, Natalia Buchman, Vladimir L.
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