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001-es BibID:BIBFORM041165
035-os BibID:PMID:14674702
Első szerző:Cui, Jianhua
Cím:Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts / Jianhua Cui, Dipak K. Das, Aldo Bertelli, Arpad Tosaki
Dátum:2003
ISSN:0300-8177
Megjegyzések:The study aimed to examine whether L-carnitine and its derivatives, acetyl-L-carnitine and propionyl-L-carnitine, were equally effective and able to improve postischemic cardiac function, reduce the incidence of reperfusion-induced ventricular fibrillation, infarct size, and apoptotic cell death in ischemic/reperfused isolated rat hearts. There are several studies indicating that L-carnitine, a naturally occurring amino acid and an essential cofactor, can improve mechanical function and substrate metabolism not only in hypertrophied or failing myocardium but also in ischemic/reperfused hearts. The effects of L-carnitine, acetyl-L-carnitine, and propionyl-L-carnitine, on the recovery of heart function, incidence of reperfusion-induced ventricular fibrillation (VF), infarct size, and apoptotic cell death after 30 min ischemia followed by 120 min reperfusion were studied in isolated working rat hearts. Hearts were perfused with various concentrations of L-carnitine (0.5 and 5 mM), acetyl-L-carnitine (0.5 and 5 mM), and propionyl-L-carnitine (0.05, 0.5, and 5 mM), respectively, for 10 min before the induction of ischemia. Postischemic recovery of CF, AF, and LVDP was significantly improved in all groups perfused with 5 mM of L-carnitine, acetyl-L-carnitine, and propionyl-L-carnitine. Significant postischemic ventricular recovery was noticed in the hearts perfused with 0.5 mM of propionyl-L-carnitine, but not with the same concentration of L-carnitine or L-acetyl carnitine. The incidence of reperfusion VF was reduced from its control value of 90 to 10% (p < 0.05) in hearts perfused with 5 mM of propionyl-L-carnitine only. Other doses of various carnitines failed to reduce the incidence of VF. The protection in CF, AF, LVDP, and VF reflected in a reduction in infarct size and apoptotic cell death in hearts treated with various concentrations of carnitine derivatives. The difference between effectiveness of various carnitines on the recovery of postischemic myocardium may be explained by different membrane permeability properties of carnitine and its derivatives.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Molecular and Cellular Biochemistry. - 254 : 1-2 (2003), p. 227-234. -
További szerzők:Das, Dipak Kumar Bertelli, Aldo Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM037300
Első szerző:Das, Somak
Cím:Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts : insight with genomics / Das Somak, Mukherjee Subhendu, Lekli Istvan, Gurusamy Narasimman, Bardhan Jayeeta, Raychoudhury Utpal, Chakravarty Runu, Banerji Sandip, Knowlton Anne A., Das Dipak K.
Dátum:2012
ISSN:0300-8177
Megjegyzések:Most clinical trials with vitamin E could not lower cholesterol and thus, have been deemed unsuccessful. Recently, tocotrienols, isomers of vitamin E have been found to lower LDL levels. To explore if tocotrienols could be the drug target for vitamin E, rabbits were kept on cholesterol diet for 60 days supplemented with tocotrienol-alpha, tocotrienol-delta, and tocotrienol-gamma for the last 30 days. The serum cholesterol levels (in mmol/l) were 24.4 (tocotrienol-alpha), 34.9 (tocotrienol-delta), 19.8 (tocotrienol-gamma) vs. 39.7 (control). Left ventricular function including aortic flow and developed pressure exhibited significantly improved recovery with tocotrienol-gamma and -alpha, but not with tocotrienol-delta. The myocardial infarct size showed a similar pattern: 33% (tocotrienol-alpha), 23% (tocotrienol-gamma), and 47% (tocotrienol-delta). To examine the molecular mechanisms of cardioprotective effects, gene expression profile was determined using Atlas 1.2/1.2II followed by determination of gene profiles using PedQuest 8.3 software. Based on genomic profiles, the following cholesterol-related proteins were examined: FABP, TGF-beta (cholesterol suppresses TGF-beta), ET-1 (increased by hypercholesterolemia), SPOT 14 (linked with hypercholesterolemia), and matrix metalloproteinase (MMP) 2 and MMP9 (cholesterol regulates MMP2 and MMP9 expression) in the heart. Consistent with the cardioprotective effects of tocotrienol-alpha and -gamma, these two isomers reduced ET-1, decreased MMP2 and MM9, increased TGF-beta and reduced SPOT 14, while tocotrienol-delta had no effects. The results of the present study demonstrate that the two isomers of tocotrienols, alpha and gamma, render the hypercholesterolemic hearts resistant to ischemic reperfusion injury by lowering several hypercholesterolemic proteins including MMP2, MMP9, ET-1, and SPOT 14 and upregulating TGF-beta.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Molecular And Cellular Biochemistry. - 360 : 1-2 (2012), p. 35-45. -
További szerzők:Mukherjee, Subhendu Lekli István (1981-) (gyógyszerész) Gurusamy, Narasimman Bardhan, Jayeeta Raychaudhuri, Utpal Chakravarty, Runu Banerji, Sandip Knowlton, Anne A. Das, Dipak Kumar
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM042052
Első szerző:Tósaki Árpád (kísérletes farmakológus, gyógyszerész)
Cím:The role of heme oxygenase signaling in various disorders / Tósaki Árpád, Das Dipak K.
Dátum:2002
Megjegyzések:Modern methods of cell and molecular biology, augmented by molecular technology, have great potential for helping to unravel the complex mechanisms of various diseases. They also have the potential to help us try to dissect the events which follow the altered physiological conditions. Thus, there is every reason to believe that some of the potential mechanisms will be translated sooner or later into the clinic. Heme oxygenase (HO)-related mechanisms play an important role in several aspects of different diseases. In the past several years, significant progress has been made in our understanding of the function and regulation of HO. The objective of this article is to review current knowledge relating to the importance of HO mechanism in various diseases including myocardial ischemia/reperfusion, hypertension, cardiomyopathy, organ transplantation, endotoxemia, lung diseases, and immunosuppression. The morbidity and mortality of these diseases remain high even with optimal medical management. Furthermore, in this review, we consider various factors influencing the HO system and finally assess current pharmacological approaches to their control.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
HEM
Megjelenés:Molecular and Cellular Biochemistry. - 232 : 1-2 (2002), p. 149-157. -
További szerzők:Das, Dipak Kumar
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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