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001-es BibID:	BIBFORM014451
Első szerző:	Mukherjee, Subhendu
Cím:	Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury / Subhendu Mukherjee, Istvan Lekli, Diptarka Ray, Hiranmoy Gangopadhyay, Utpal Raychaudhuri, Dipak K. Das
Dátum:	2010
ISSN:	0007-1145
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	British Journal Of Nutrition. - 103 : 06 (2010), p. 815-823. -
További szerzők:	Lekli István (1981-) (gyógyszerész) Ray, Diptarka Gangopadhyay, Hiranmoy Raychaudhuri, Utpal Das, Dipak Kumar
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM027560
Első szerző:	Pataki Tünde (farmakológus, klinikai farmakológus)
Cím:	Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts / Tunde Pataki, Istvan Bak, Peter Kovacs, Debasis Bagchi, Dipak K. Das, Arpad Tosaki
Dátum:	2002
ISSN:	0002-9165
Megjegyzések:	Background: Increasing evidence shows that red wine consumption has cardioprotective effects. These effects have been attributed to the polyphenolic compounds in grapes. Objective: We studied the effects of red grape seed proanthocyanidins on the recovery of postischemic function in isolated rat hearts. Design: Two groups of rats were fed different doses of proanthocyanidin-rich extract for 3 wk and another group was untreated and served as controls. The animals were then anesthetized and the hearts were isolated and subjected to 30 min of ischemia followed by 2 h of reperfusion. Coronary effluents were collected during the third minute of reperfusion for measurement of oxygen free radicals by using electron spin resonance spectroscopy. Results: In rats treated with 50 and 100 mg grape seed proanthocyanidins/kg, the incidence of reperfusion-induced ventricular fibrillation was reduced from its control value of 92% to 42% and 25%, respectively (P < 0.05 for both). The incidence of ventricular tachycardia showed the same pattern. In rats treated with 100 mg proanthocyanidins/kg, the recovery of coronary flow, aortic flow, and developed pressure after 60 min of reperfusion was improved by 32% ± 8%, 98% ± 8%, and 37% ± 3%, respectively (P < 0.05 for all) compared with untreated control rats. Electron spin resonance studies indicated that proanthocyanidins significantly inhibited the formation of oxygen free radicals. In rats treated with 100 mg proanthocyanidins/kg, free radical intensity was reduced by 75% ± 7% (P < 0.05) compared with the control rats. Conclusion: Grape seed proanthocyanidins have cardioprotective effects against reperfusion-induced injury via their ability to reduce or remove, directly or indirectly, free radicals in myocardium that is reperfused after ischemia.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	American Journal Of Clinical Nutrition 75 : 5 (2002), p. 894-899. -
További szerzők:	Bak István (1975-) (vegyész, analitikus, farmakológus) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Bagchi, Debasis Das, Dipak Kumar Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL
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001-es BibID:	BIBFORM005200
Első szerző:	Toufektsian, Marie-Claire
Cím:	Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury / Marie-Claire Toufektsian, Michel de Lorgeril, Patricia Salen, Norbert Nagy, Maria Benedetta Donati, Lucia Giordano, Hans-Peter Mock, Silke Peterek, Katia Petroni, Roberto Pilu, Domenico Rotilio, Chiara Tonelli, Joel de Leiris, François Boucher, Cathie Martin
Dátum:	2008
Megjegyzések:	Consumption of flavonoid-rich foods and beverages is thought to reduce the risk of cardiovascular diseases. Whereas the biological activities of flavonoids have been characterized in vitro, there are no clear experimental data demonstrating that chronic dietary intake and intestinal absorption of flavonoids actually protects the heart against ischemia-reperfusion injury. We tested whether long-term consumption of specific flavonoids (anthocyanins) included in normal food could render the heart of rats more resistant to myocardial infarction. Maize kernels that differed specifically in their accumulation of anthocyanins were used to prepare rodent food in which anthocyanins were either present or absent. Male Wistar rats were fed the anthocyanin-rich (ACN-rich) or the anthocyanin-free (ACN-free) diet for a period of 8 wk. Anthocyanins were significantly absorbed and detected in the blood and urine of only rats fed the ACN-rich diet. In Langendorff preparations, the hearts of rats fed the ACN-rich diet were more resistant to regional ischemia and reperfusion insult. Moreover, on an in vivo model of coronary occlusion and reperfusion, infarct size was reduced in rats that ate the ACN-rich diet than in those that consumed the ACN-free diet (P < 0.01). Cardioprotection was associated with increased myocardial glutathione levels, suggesting that dietary anthocyanins might modulate cardiac antioxidant defenses. Our findings suggest important potential health benefits of foods rich in anthocyanins and emphasize the need to develop anthocyanin-rich functional foods with protective activities for promoting human health.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	The Journal of Nutrition. - 138 : 4 (2008), p. 747-752. -
További szerzők:	Lorgeril, Michel de Salen, Patricia Nagy Norbert (1977-) (kísérletes farmakológus) Donati, Maria Benedetta Giordano, Lucia Mock, Hans-Peter Peterek, Silke Petroni, Katia Pilu, Roberto Rotilio, Domenico Tonelli, Chiara de Leiris, Joel Boucher, Francois Martin, Cathie
Internet cím:	elektronikus változat
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