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001-es BibID:	BIBFORM110530
Első szerző:	Fésüs Adina (gyógyszerész)
Cím:	The pharmacist's role in optimising surgical antibacterial prophylaxis (SAP) / A. Fésüs, R. Benkő, M. Matuz, Z. Engi, R. Ruzsa, H. Hambalek, Á. M. Fésüs, T. Bazsó, Z. Csernátony, I. Bácskay, G. Kardos
Dátum:	2023
Megjegyzések:	Background and importance Perioperative antibiotic use is a common reason for antibiotic misuse. Evidence suggests that adherence to SAP guidelines may improve outcomes. Aim and objectives The purpose of this study was to analyse the impact of pharmacist-led antibiotic stewardship interventions on SAP guideline compliance. Materials and methods The study was conducted at an Orthopedic Department of a tertiary care medical center. SAP compliance and antibiotic exposure in the pre-intervention and intervention period was compared using chi-square, Fisher exact, and Mann-Whitney tests, as appropriate. Prophylactic antibiotic use in orthopedic joint arthroplasties (overall guideline adherence: agent, dose, frequency, duration), clinical outcomes (length of stay-LOS, number of surgical site infections-SSIs), antibiotic exposure and direct antibiotic costs were compared between pre-intervention and intervention periods. Results Significant improvement in mean SAP duration (by 42.9%, 4.1 ? 2.1 vs. 2.1 ? 1.9 days, p < 0.001), and overall guideline adherence regarding antibiotic use (by 56.2%, from 2% to 58.2%, p < 0.001) were observed. A significant decrease was observed in antibiotic exposure in SAP (by 41%, from 6.1 ? 0.05 to3.6 ? 4.3 DDD/patient, p < 0.001), average prophylactic antibiotic cost (by 54.8%, 9278.8 ? 6094.3 vs. 3598.2 ? 3354.6 HUF/patient), and mean LOS (by 37.2%, from 11.2 ? 7 to 7.62 ? 3 days, p < 0.001); and a slight decrease in the number of confirmed SSIs was found between the two periods (by 1.8%, from 3% to 1.2%, p = 0.21). Conclusion and relevance Continuous presence of the clinical pharmacist led to significant improvement in SAP guideline adherence, which was accompanied by decreased antibiotic exposure and cost.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idézhető absztrakt folyóiratcikk
Megjelenés:	European Journal of Hospital Pharmacy. - 30 : Suppl1 (2023), p. A109-A110. -
További szerzők:	Benkő Ria Matuz Mária Engi Zsófia Ruzsa Roxána Hambalek Helga Fésüs Márton Á. Bazsó Tamás (1974-) (ortopéd sebész) Csernátony Zoltán (1959-2023) (ortopéd sebész, traumatológus) Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Kardos Gábor (1974-) (absztraktok)
Pályázati támogatás:	TKP2021-EGA-18 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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