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001-es BibID:	BIBFORM030625
Első szerző:	Bodnár Ibolya
Cím:	Effect of neonatal treatment with monosodium glutamate on dopaminergic and L-DOPA-ergic neurons of the medial basal hypothalamus and on prolactin and MSH secretion of rats / Ibolya Bodnár, Pál Göőz, Hitoshi Okamura, Béla E. Tóth, Miklós Vecsernyés, Béla Halász, György M. Nagy
Dátum:	2001
ISSN:	0361-9230
Megjegyzések:	The effect of neonatal treatment with monosodium L-glutamate (MSG) on the dopaminergic systems of the medial basal hypothalamus has been investigated using tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) immunocytochemistry. Changes in plasma levels of prolactin (PRL) and alpha-melanocyte-stimulating hormone (MSH) have also been determined in intact and in MSG-treated rats after inhibition of TH by alpha-methyl-p-tyrosine (alpha-MpT) or without inhibition of enzyme activity. Monosodium glutamate resulted in a 40% reduction in the number of TH immunopositive tuberoinfundibular neurons, but no change in the number of AADC-positive tuberoinfundibular nerve cells, indicating that this reduction has occurred mainly in TH-positive but AADC-negative elements, i.e., in L-DOPA-ergic neurons. In contrast, MSG did not cause changes in the number of TH and AADC immunoreactive neurons of the periventriculohypophysial and tuberohypophysial dopaminergic systems, and it did not influence basal plasma PRL levels. alpha-methyl-p-tyrosine has increased plasma PRL concentrations in both control and MSG-treated rats of both sexes, but significantly higher responses were detected in females. None of the treatments had any effect on plasma MSH level. These findings suggest that MSG affects primarily L-DOPA-ergic neurons located in the ventrolateral part of the arcuate nucleus, but not dopaminergic neurons situated in the dorsomedial part of the arcuate nucleus; neither PRL nor MSH secretion is altered by MSG; a significant sex difference exists in the pituitary PRL response to inhibition of TH, and this response is not affected by MSG.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban arcuate nucleus tyrosine hydroxylase aromatic L-amino acid decarboxylase immunocytochemistry
Megjelenés:	Brain Research Bulletin 55 : 6 (2001), p. 767-774. -
További szerzők:	Göőz Pál Okamura, Hitoshi Tóth E. Béla (1960-) (orvos) Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Halász Béla Nagy György M.
Pályázati támogatás:	T-30748 OTKA T-029004 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM030669
Első szerző:	Horváth Katalin M.
Cím:	Suckling-induced increase in cyclic AMP exclusively in the central region of the rat adenohypophysis / Katalin M. Horváth, Anikó Somogyvári-Vigh, Zoltán Kandár, Miklós Vecsernyés, Akira Arimura, György M. Nagy
Dátum:	2000
ISSN:	0006-8993
Megjegyzések:	Investigating the cellular events in the pituitary gland, the intracellular cyclic AMP (cAMP) of the neural lobe (NL), intermediate lobe (IL), the inner (IZ-AL) and outer zone (OZ-AL) of the anterior lobe (AL) have been measured during the suckling stimulus. Ten-minutes suckling, parallel to the elevation of plasma PRL, induced a significant increase of cAMP concentration in the IZ-AL. In contrast, 10- and 30-min suckling resulted in a decrease of cAMP level in the NL. Changes in cAMP of the OZ-AL and the IL as well as in the plasma level of alpha-MSH could not be detected. These region-specific changes of cAMP in the pituitary gland during suckling stimulus seems to be related to interacting neuroendocrine signals delivered concomitantly from the hypothalamus and from the NIL to the IZ-AL.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban suckling stimulus inner zone of adenohypophysis prolactin cyclic AMP egyetemen (Magyarországon) készült közlemény
Megjelenés:	Brain Research 873 : 1 (2000), p. 140-144. -
További szerzők:	Somogyvári-Vigh Anikó Kandár Zoltán Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Arimura, Akira Nagy György M.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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