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001-es BibID:	BIBFORM109465
035-os BibID:	(cikkazonosító)666 (Scopus)85151111518 (WoS)000968394300001
Első szerző:	Kurshed, Ali Abbas Mohammad
Cím:	Taste Preference-Related Genetic Polymorphisms Modify Alcohol Consumption Behavior of the Hungarian General and Roma Populations / Ali Abbas Mohammad Kurshed, Ferenc Vincze, Péter Pikó, Zsigmond Kósa, János Sándor, Róza Ádány, Judit Diószegi
Dátum:	2023
ISSN:	2073-4425
Megjegyzések:	Harmful alcohol consumption has been considered a major public health issue globally, with the amounts of alcohol drunk being highest in the WHO European Region including Hungary. Alcohol consumption behaviors are complex human traits influenced by environmental factors and numerous genes. Beyond alcohol metabolization and neurotransmitter gene polymorphisms, taste preference-related genetic variants may also mediate alcohol consumption behaviors. Applying the Alcohol Use Disorders Identification Test (AUDIT) we aimed to elucidate the underlying genetic determinants of alcohol consumption patterns considering taste preference gene polymorphisms (TAS1R3 rs307355, TAS2R38 rs713598, TAS2R19 rs10772420 and CA6 rs2274333) in the Hungarian general (HG) and Roma (HR) populations. Alcohol consumption assessment was available for 410 HG and 387 HR individuals with 405 HG and 364 HR DNA samples being obtained for genotyping. No significant associations were found between TAS1R3 rs307355, TAS2R19 rs10772420, and CA6 rs2274333 polymorphisms and alcohol consumption phenotypes. Significant associations were identified between TAS2R38 rs713598 and the number of standard drinks consumed in the HG sample (genotype GG negatively correlated with the number of standard drinks; coef: ?0.136, p = 0.028) and the prevalence of having six or more drinks among Roma (a negative correlation was identified in the recessive model; genotype GG, coef: ?0.170, p = 0.049), although, none of these findings passed the Bonferroni-corrected probability criterion (p > 0.05). Nevertheless, our findings may suggest that alcohol consumption is partially driven by genetically determined taste preferences in our study populations. Further studies are required to strengthen the findings and to understand the drivers of alcohol consumption behavior in more depth.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk alcohol consumption AUDIT taste preference genetic polymorphisms genetic association Hungarian population Roma population
Megjelenés:	Genes. - 14 : 3 (2023), p. 1-16. -
További szerzők:	Vincze Ferenc (1987-) (táplákozástudományi szakember, epidemiológus) Pikó Péter (1987-) (biológus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Diószegi Judit (1978-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 Egyéb Hungarian Academy of Sciences TK2016-78 Egyéb Eötvös Loránd Research Network (TKCS-2021/32) Egyéb 135784 National Research, Development, and Innovation Fund of Hungary Egyéb
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001-es BibID:	BIBFORM085393
035-os BibID:	(cikkazonosító)516
Első szerző:	Llanaj, Erand (táplálkozási epidemiológus)
Cím:	Applicability of Obesity-Related SNPs and their Effect Size Measures Defined on Populations with European Ancestry for Genetic Risk Estimation among Roma / Erand Llanaj, Péter Pikó, Károly Nagy, Gábor Rácz, Sándor János, Zsigmond Kósa, Szilvia Fiatal, Róza Ádány
Dátum:	2020
ISSN:	2073-4425 2073-4425
Megjegyzések:	Investigations on the impact of genetic factors on the development of obesity have been limited regarding the Roma population?the largest and most vulnerable ethnic minority in Europe of Asian origin. Genetic variants identified from genetic association studies are primarily from European populations. With that in mind, we investigated the applicability of data on selected obesity?related single nucleotide polymorphisms (SNPs), obtained from the Hungarian general (HG) population of European origin, on the Hungarian Roma (HR) population. Twenty preselected SNPs in susceptible alleles, known to be significantly associated with obesity?related phenotypes, were used to estimate the effect of these SNPs on body mass index (BMI) and waist circumference (WC) in HG (N = 1783) and HR (N = 1225) populations. Single SNP associations were tested using linear and logistic regression models, adjusted for known covariates. Out of 20 SNPs, four located in FTO (rs1121980, rs1558902, rs9939609, and rs9941349) showed strong association with BMI and WC as continuous variables in both samples. Computations based on Adult Treatment Panel III (ATPIII) and the International Diabetes Federation's (IDF) European and Asian criteria showed rs9941349 in FTO to be associated only with WC among both populations, and two SNPs rs2867125, rs6548238) in TMEM18 associated with WC only in HG population. A substantial difference (both in direction and effect size) was observed only in the case of rs1801282 in PPAR? on WC as a continuous outcome. Findings suggest that genetic risk scores based on counting SNPs with relatively high effect sizes, defined based on populations with European ancestry, can sufficiently allow estimation of genetic susceptibility for Roma. Further studies are needed to clarify the role of SNP(s) with protective effect(s).
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk obesity single nucleotide polymorphisms genetic risk score susceptibility Roma Hungary
Megjelenés:	Genes. - 11 (2020), p. 1-13. -
További szerzők:	Pikó Péter (1987-) (biológus) Nagy Károly Rácz Gábor Sándor János (1966-) (orvos-epidemiológus) Kósa Zsigmond (1953-) (orvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 Egyéb MTA11010 Egyéb TK2016-78 Egyéb
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001-es BibID:	BIBFORM082148
035-os BibID:	(cikkazonosító)942
Első szerző:	Werissa, Nardos Abebe
Cím:	SNP-Based Genetic Risk Score Modeling Suggests No Increased Genetic Susceptibility of the Roma Population to Type 2 Diabetes Mellitus / Nardos Abebe Werissa, Peter Piko, Szilvia Fiatal, Zsigmond Kosa, Janos Sandor, Roza Adany
Dátum:	2019
ISSN:	2073-4425
Megjegyzések:	Background: In a previous survey, an elevated fasting glucose level (FG) and/or known type 2 diabetes mellitus (T2DM) were significantly more frequent in the Roma population than in the Hungarian general population. We assessed whether the distribution of 16 single nucleotide polymorphisms (SNPs) with unequivocal e ects on the development of T2DM contributes to this higher prevalence. Methods: Genetic risk scores, unweighted (GRS) and weighted (wGRS), were computed and compared between the study populations. Associations between GRSs and FG levels and T2DM status were investigated in separate and combined study populations. Results: The Hungarian general population carried a greater genetic risk for the development of T2DM (GRSGeneral = 15.38 2.70 vs. GRSRoma = 14.80 2.68, p < 0.001; wGRSGeneral = 1.41 0.32 vs. wGRSRoma = 1.36 0.31, p < 0.001). In the combined population models, GRSs and wGRSs showed significant associations with elevated FG (p < 0.001) and T2DM (p < 0.001) after adjusting for ethnicity, age, sex, body mass index (BMI), high-density Lipoprotein Cholesterol (HDL-C), and triglyceride (TG). In these models, the e ect of ethnicity was relatively strong on both outcomes (FG levels: ethnicity = 0.918, p < 0.001; T2DM status: ORethnicity = 2.484, p < 0.001). Conclusions: The higher prevalence of elevated FG and/or T2DM among Roma does not seem to be directly linked to their increased genetic load but rather to their environmental/cultural attributes. Interventions targeting T2DM prevention among Roma should focus on harmful environmental exposures related to their unhealthy lifestyle.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk type 2diabetes Roma genetic risk score targeted intervention single nucleotide polymorphism
Megjelenés:	Genes. - 10 : 11 (2019), p. 1-16. -
További szerzők:	Pikó Péter (1987-) (biológus) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	TÁMOP 4.2.1. B-09/1/KONV-2010-0007 Egyéb TÁMOP 4.2.2. A-11/1/KONV-2012-0031 Egyéb GINOP-2.3.2-15-2016-00005 Egyéb MTA11010 Egyéb TK2016-78 Egyéb
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