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001-es BibID:BIBFORM103834
035-os BibID:(cikkazonosító)9036 (scopus)85137124306 (wos)000845745000001
Első szerző:Gálné Remenyik Judit (kémia tanár, okleveles vegyész)
Cím:Comparison of the Modulating Effect of Anthocyanin-Rich Sour Cherry Extract on Occludin and ZO-1 on Caco-2 and HUVEC Cultures / Remenyik Judit, Biró Attila, Klusóczki Ágnes, Juhász Krisztián Zoltán, Szendi-Szatmári Tímea, Kenesei Ádám, Szőllősi Erzsébet, Vasvári Gábor, Stündl László, Fenyvesi Ferenc, Váradi Judit, Markovics Arnold
Dátum:2022
ISSN:1422-0067
Megjegyzések:Increased permeability of the epithelial and endothelial cell layers results in the onset of pathogenic mechanisms. In both cell types, cell?cell connections play a regulatory role in altering membrane permeability. The aim of this study was to investigate the modulating effect of anthocyanin-rich extract (AC) on TJ proteins in inflammatory Caco-2 and HUVEC monolayers. Distribution of Occludin and zonula occludens-1 (ZO-1) were investigated by immunohistochemical staining and the protein levels were measured by flow cytometry. The mRNA expression was determined by quantitative real-time PCR. The transepithelial electrical resistance (TEER) values were measured during a permeability assay on HUVEC cell culture. As a result of inflammatory induction by TNF-?, redistribution of proteins was observed in Caco-2 cell culture, which was reduced by AC treatment. In HUVEC cell culture, the decrease in protein and mRNA expression was more dominant during inflammatory induction, which was compensated for by the AC treatment. Overall, AC positively affected the expression of the examined cell-binding structures forming the membrane on both cell types
Tárgyszavak:Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
tight junction (TJ)
zonula occludens-1 (ZO-1)
occludin
Caco-2
HUVEC
Megjelenés:International Journal Of Molecular Sciences. - 23 : 16 (2022), p. 1-13. -
További szerzők:Biró Attila (1988-) (okleveles biomérnök) Klusóczki Ágnes (1991-) (biotechnológus) Juhász Krisztián Zoltán Szendi-Szatmári Tímea (1989-) (molekuláris biológus) Kenesei Ádám (1989-) Szőllősi Erzsébet (1983-) (biológus) Vasvári Gábor (1990-) (gyógyszerész, gyógyszertechnológus) Stündl László (1970-) (agrármérnök) Fenyvesi Ferenc (1977-) (gyógyszerész, gyógyszertechnológus) Váradi Judit (1973-) (gyógyszerész, gyógyszertechnológus) Markovics Arnold (1988-) (molekuláris biológus)
Pályázati támogatás:TKP2020-NKA-04
Egyéb
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM116322
035-os BibID:(cikkazonosító)16504 (WOS)001113721200001 (Scopus)85177740392
Első szerző:Lőrincz Hajnalka (biológus)
Cím:Gender-Dependent Associations between Serum Betatrophin Levels and Lipoprotein Subfractions in Diabetic and Nondiabetic Obese Patients / Hajnalka Lőrincz, Sára Csiha, Balázs Ratku, Sándor Somodi, Ferenc Sztanek, Ildikó Seres, György Paragh, Mariann Harangi
Dátum:2023
ISSN:1422-0067
Megjegyzések:Betatrophin, also known as angiopoietin-like protein 8 (ANGPTL8), mainly plays a role in lipid metabolism. To date, associations between betatrophin and lipoprotein subfractions are poorly investigated. For this study, 50 obese patients with type 2 diabetes (T2D) and 70 nondiabetic obese (NDO) subjects matched in gender, age, and body mass index (BMI) as well as 49 gender- and age-matched healthy, normal-weight controls were enrolled. Serum betatrophin levels were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint gel electrophoresis. Betatrophin concentrations were found to be significantly higher in the T2D and NDO groups compared to the controls in all subjects and in females, but not in males. We found significant positive correlations between triglyceride, very low density lipoprotein (VLDL), large LDL (low density lipoprotein), small LDL, high density lipoprotein (HDL) -6-10 subfractions, and betatrophin, while negative correlations were detected between betatrophin and IDL, mean LDL size, and HDL-1-5. Proportion of small HDL was the best predictor of betatrophin in all subjects. Small LDL and large HDL subfractions were found to be the best predictors in females, while in males, VLDL was found to be the best predictor of betatrophin. Our results underline the significance of serum betatrophin measurement in the cardiovascular risk assessment of obese patients with and without T2D, but gender differences might be taken into consideration.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
betatrophin
angiopoietin-like protein 8
triglyceride
lipoprotein subfractions
high-density lipoprotein
diabetes
obesity
Megjelenés:International Journal Of Molecular Sciences. - 24 : 22 (2023), p. 1-13. -
További szerzők:Csiha Sára (1985-) (Biológus) Ratku Balázs (1985-) (mentőtiszt) Somodi Sándor (1977-) (belgyógyász) Sztanek Ferenc (1982-) (orvos) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
Pályázati támogatás:K142273
OTKA
PD146136
OTKA
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM108875
035-os BibID:(cikkazonosító)4115 (Scopus)85149053802 (WoS)000945033100001
Első szerző:Lőrincz Hajnalka (biológus)
Cím:Impaired Organokine Regulation in Non-Diabetic Obese Subjects : halfway to the Cardiometabolic Danger Zone / Hajnalka Lőrincz, Balázs Ratku, Sára Csiha, Ildikó Seres, Zoltán Szabó, György Paragh, Mariann Harangi, Sándor Somodi
Dátum:2023
ISSN:1422-0067
Megjegyzések:Altered organokine expression contributes to increased cardiometabolic risk in obesity. Our aim was to evaluate the associations of serum afamin with glucose homeostasis, atherogenic dyslipidemia, and other adipokines in severe obesity to clarify the early metabolic alterations. 106 non diabetic obese (NDO) subjects and 62 obese patients with type 2 diabetes matched for age, gender, and body mass index (BMI) were enrolled in this study. We compared their data with 49 healthy, lean controls. Serum afamin and retinol-binding protein 4 (RBP4), as well as plasma plasminogen activator inhibitor-1 (PAI-1), were measured with ELISA, and lipoprotein subfractions were analyzed using Lipoprint gel electrophoresis. Afamin and PAI-1 found to be significantly higher in the NDO and T2M group (p < 0.001 and p < 0.001, respectively) than in the controls. In contrast, RBP4 was unexpectedly lower in the NDO and T2DM group compared to controls (p < 0.001). Afamin showed negative correlations with mean LDL size and RBP4, but positive correlations with anthropometric, glucose/lipid parameters, and PAI-1 in both the overall patients and the in NDO + T2DM groups. BMI, glucose, intermediate HDL, and small HDL were predictors of afamin. Afamin may serve as a biomarker for the severity of cardiometabolic disturbances in obesity. The complexity of organokine patterns in NDO subjects draws attention to the diverse spectrum of obesity-related comorbidities.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
obesity
type 2 diabetes
insulin resistance
afamin
plasminogen-activator inhibitor-1
retinol binding protein 4
lipid metabolism
lipoprotein subfraction
cardiometabolic
Megjelenés:International Journal Of Molecular Sciences. - 24 : 4 (2023), p. 1-13. -
További szerzők:Ratku Balázs (1985-) (mentőtiszt) Csiha Sára (1985-) (Biológus) Seres Ildikó (1954-) (biokémikus) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Somodi Sándor (1977-) (belgyógyász)
Pályázati támogatás:PD124126
OTKA
K142273
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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