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001-es BibID:BIBFORM115317
035-os BibID:(WoS)001081359700002 (Scopus)85173920248
Első szerző:Bákány Bernadett (mérnök)
Cím:The bZIP-type transcription factors NapA and RsmA modulate the volumetric ratio and the relative superoxide ratio of mitochondria in Aspergillus nidulans / Bernadett Bákány, Réka Antal, Péter Szentesi, Tamás Emri, Éva Leiter, László Csernoch, Nancy P. Keller, István Pócsi, Beatrix Dienes
Dátum:2023
ISSN:2676-8615 2676-8607
Megjegyzések:Basic leucine zipper (bZIP) transcription factors are crucial components of diferentiation, cellular homeostasis and the environmental stress defense of eukaryotes. In this work, we further studied the consequence of gene deletion and overexpression of two bZIP transcription factors, NapA and RsmA, on superoxide production, mitochondrial morphology and hyphal diameter of Aspergillus nidulans. We have found that reactive oxygen species production was infuenced by both gene deletion and overexpression of napA under tert-butylhydroperoxide (tBOOH) elicited oxidative stress. Furthermore, gene expression of napA negatively correlated with mitochondrial volumetric ratio as well as sterigmatocystin production of A. nidulans. High rsmA expression was accompanied with elevated relative superoxide ratio in the second hyphal compartment. A negative correlation between the expression of rsmA and catalase enzyme activity or mitochondrial volumetric ratio was also confrmed by statistical analysis. Hyphal diameter was independent on either rsmA and napA expression as well as 0.2 mM tBOOH treatment.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
bZIP-type transcription factors
tBOOH stress
Superoxide level
Mitochondrial volumetric ratio
Hyphal diameter
Megjelenés:Biologia Futura. - 74 : 3 (2023), p. 337-346. -
További szerzők:Antal Réka (1999-) (Biotechnológia MSc hallgató) Szentesi Péter (1967-) (élettanász) Emri Tamás (1969-) (biológus) Leiter Éva (1976-) (biológus) Csernoch László (1961-) (élettanász) Keller, Nancy P. Pócsi István (1961-) (vegyész) Dienes Beatrix (1972-) (élettanász, molekuláris biológus)
Pályázati támogatás:EFOP-3.6.1-16-2016-00022
EFOP
K 119494
Egyéb
NN 125671
NKFIH
K 131767
NKFIH
GINOP-2.3.3-15-2016-00020
GINOP
TKP2021-EGA-20
Egyéb
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001-es BibID:BIBFORM105521
035-os BibID:(WOS)000811416200001 (Scopus)85131946537
Első szerző:Emri Tamás (biológus)
Cím:Biologia futura: combinatorial stress responses in fungi / Tamás Emri, Katalin Forgács, István Pócsi
Dátum:2022
ISSN:2676-8615 2676-8607
Megjegyzések:In the ever-changing fungal environment, fungi have to cope with a wide array of very different stresses. These stresses frequently act in combination rather than independently, i.e., they quickly follow one another or occur concomitantly. Combinatorial stress response studies revealed that the response of fungi to a stressor is highly dependent on the simultaneous action of other stressors or even on earlier stresses to which the fungi adapted. Several important phenomena were discovered, such as stress pathway interference, acquired stress tolerance, stress response memory or stress cross-protection/sensitization, which cannot be interpreted when we study the consequences of a single stressor alone. Due to the interactions between stressors and stress responses, a stress response that develops under a combined stress is not the simple summation of stress responses observed during single stress treatments. Based on the knowledge collected from single stress treatment experiments, we cannot predict how fungi will respond to a certain combination of stresses or even whether this combination will be more harmful than single stress treatments. This uncertainty warns us that if we want to understand how fungi adapt to a certain habitat (e.g., to the human body) to find a point of weakness in this adaptation, we must understand how the fungi cope with combinations of stresses, rather than with single stressors.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
Acquired stress tolerance
Combinatorial stress
Fungi
Stress pathway interference
Stress cross-protection
Megjelenés:Biologia Futura. - 73 : 2 (2022), p. 207-217. -
További szerzők:Forgács Katalin Pócsi István (1961-) (vegyész)
Pályázati támogatás:NIFIH-K-131767
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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