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001-es BibID:	BIBFORM105346
035-os BibID:	(cikkazonosító)117727192211118 (WOS)000827730100001 (Scopus)85134331698
Első szerző:	Pócsi István (vegyész)
Cím:	Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health / István Pócsi, Mark E. Dockrell, Robert G. Price
Dátum:	2022
ISSN:	1177-2719
Megjegyzések:	Environmental and occupational exposure to heavy metals and metalloids is a major global health risk. The kidney is often a site of early damage. Nephrotoxicity is both a major consequence of heavy metal exposure and potentially an early warning of greater damage. A paradigm shift occurred at the beginning of the 21st century in the field of renal medicine. The medical model of kidney failure and treatment began to give way to a social model of risk factors and prevention with important implications for environmental health. This development threw into focus the need for better biomarkers: markers of exposure to known nephrotoxins; markers of early damage for diagnosis and prevention; markers of disease development for intervention and choice of therapy. Constituents of electronic waste, e-waste or e-pollution, such as cadmium (Cd), lead (Pb), mercury (HG), arsenic (As) and silica (SiO2) are all potential nephrotoxins; they target the renal proximal tubules through distinct pathways. Different nephrotoxic biomarkers offer the possibility of identifying exposure to individual pollutants. In this review, a selection of prominent urinary markers of tubule damage is considered as potential tools for identifying environmental exposure to some key metallic pollutants.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Heavy metals nephrotoxicity kidney injury urinary biomarkers environmental and occupational exposure
Megjelenés:	Biomarker Insights. - 17 (2022), p. 1-13. -
További szerzők:	Dockrell, Mark E. C. Price, Robert G.
Pályázati támogatás:	GINOP-2.3.2-15-2016-00062 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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