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001-es BibID:	BIBFORM119878
035-os BibID:	(Scopus)85125190008 (WOS)000769555600001
Első szerző:	Meng, Jiali
Cím:	GalR, GalX and AraR co-regulate D-galactose and L-arabinose utilization in Aspergillus nidulans / Jiali Meng, Zoltán Németh, Mao Peng, Erzsébet Fekete, Sandra Garrigues, Anna Lipzen, Vivian Ng, Emily Savage, Yu Zhang, Igor V. Grigoriev, Miia R. Mäkelä, Levente Karaffa, Ronald P. de Vries
Dátum:	2022
ISSN:	1751-7915
Megjegyzések:	Filamentous fungi produce a wide variety of enzymes in order to efficiently degrade plant cell wall polysaccharides. The production of these enzymes is controlled by transcriptional regulators, which also control the catabolic pathways that convert the released monosaccharides. Two transcriptional regulators, GalX and GalR, control d-galactose utilization in the model filamentous fungus Aspergillus nidulans, while the arabinanolytic regulator AraR regulates l-arabinose catabolism. d-Galactose and l-arabinose are commonly found together in polysaccharides, such as arabinogalactan, xylan and rhamnogalacturonan I. Therefore, the catabolic pathways that convert d-galactose and l-arabinose are often also likely to be active simultaneously. In this study, we investigated the interaction between GalX, GalR and AraR in d-galactose and l-arabinose catabolism. For this, we generated single, double and triple mutants of the three regulators, and analysed their growth and enzyme and gene expression profiles. Our results clearly demonstrated that GalX, GalR and AraR co-regulate d-galactose catabolism in A. nidulans. GalX has a prominent role on the regulation of genes of d-galactose oxido-reductive pathway, while AraR can compensate for the absence of GalR and/or GalX.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk transcriptional activator xlnr primary carbon metabolism d-xylose reductase catabolic pathway beta-galactosidase missing link identification dehydrogenase niger evolution
Megjelenés:	Microbial Biotechnology. - 15 : 6 (2022), p. 1839-1851. -
További szerzők:	Németh Zoltán (1987-) (biomérnök) Peng, Mao Fekete Erzsébet (1975-) (biotechnológus, egyetemi tanár) Garrigues, Sandra Lipzen, Anna Ng, Vivian Savage, Emily Zhang, Yu Grigoriev, Igor V. Mäkelä, Miia R. Karaffa Levente (1971-) (biotechnológus, egyetemi tanár) De Vries, Ronald P.
Pályázati támogatás:	NN128867 Egyéb K138489 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM104003
035-os BibID:	(WoS)000491305800003 (Scopus)85062544980
Első szerző:	Sipiczki Mátyás (biológus)
Cím:	Yeast two- and three-species hybrids and high-sugar fermentation / Sipiczki Matthias
Dátum:	2019
ISSN:	1751-7915
Megjegyzések:	The dominating strains of most sugar-based natural and industrial fermentations either belong to Saccharomyces cerevisiae and Saccharomyces uvarum or are their chimeric derivatives. Osmotolerance is an essential trait of these strains for industrial applications in which typically high concentrations of sugars are used. As the ability of the cells to cope with the hyperosmotic stress is under polygenic control, significant improvement can be expected from concerted modification of the activity of multiple genes or from creating new genomes harbouring positive alleles of strains of two or more species. In this review, the application of the methods of intergeneric and interspecies hybridization to fitness improvement of strains used under high-sugar fermentation conditions is discussed. By protoplast fusion and heterospecific mating, hybrids can be obtained that outperform the parental strains in certain technological parameters including osmotolerance. Spontaneous postzygotic genome evolution during mitotic propagation (GARMi) and meiosis after the breakdown of the sterility barrier by loss of MAT heterozygosity (GARMe) can be exploited for further improvement. Both processes result in derivatives of chimeric genomes, some of which can be superior both to the parental strains and to the hybrid. Three-species hybridization represents further perspectives.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Microbial Biotechnology. - 12 : 6 (2019), p. 1101-1108. -
Pályázati támogatás:	K-124417 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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