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001-es BibID:	BIBFORM119020
035-os BibID:	(Cikkazonosító)231705 (WoS)001167269900008 (Scopus)85185808880
Első szerző:	Flipphi, Michel
Cím:	An ascomycete H4 variant with an unknown function / Michel Flipphi, María Laura Harispe, Zsuzsanna Hamari, Sándor Kocsubé, Claudio Scazzocchio, Ana Ramón
Dátum:	2024
ISSN:	2054-5703
Megjegyzések:	Histone variants leading to altered nucleosome structure, dynamics and DNA accessibility occur frequently, albeit rarely for H4. We carried out a comprehensive in silico scrutiny of fungal genomes, which revealed the presence of a novel H4 variant (H4E) in the ascomycetes, throughout the Pezizomycotina, in basal species of the Taphrinomycotina and also in the Glomeromycota. The coding cognate genes show a specific intron/exon organization, different from H4 canonical genes. H4Es diverge from canonical H4s mainly in the N- and C-terminal extensions, showing marked differences in the distribution and number of Lys and Arg residues, which may result in novel post-translational modifications. In Aspergillus nidulans (Pezizomycotina, Eurotiomycetes) the H4E variant protein level is low in mycelia. However, the encoding gene is well expressed at 37?C under nitrogen starvation. H4E localizes to the nucleus and interacts with H3, but its absence or overexpression does not result in any detectable phenotype. Deletion of only one of the of the two canonical H4 genes results in a strikingly impaired growth phenotype, which indicates that H4E cannot replace this canonical histone. Thus, an H4 variant is present throughout a whole subphylum of the ascomycetes, but with hitherto no experimentally detectable function.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk ascomycetes chromatin histone H4 variant
Megjelenés:	Royal Society Open Science. - 11 : 2 (2024), p. 1-16. -
További szerzők:	Harispe, María Laura Hamari Zsuzsanna Kocsubé Sándor Scazzocchio, Claudio Ramón, Ana
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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