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001-es BibID:	BIBFORM116419
035-os BibID:	(cikkazonosító)4224 (Scopus)85173813933 (WoS)001083061000001
Első szerző:	Greff Dorina
Cím:	Myoinositols Prevent Gestational Diabetes Mellitus and Related Complications : a Systematic Review and Meta-Analysis of Randomized Controlled Trials / Dorina Greff, Szilárd Váncsa, Alex Váradi, Julia Szinte, Sunjune Park, Péter Hegyi, Péter Nyirády, Nándor Ács, Eszter Mária Horváth, Szabolcs Várbíró
Dátum:	2023
ISSN:	2072-6643
Megjegyzések:	Although gestational diabetes mellitus (GDM) has several short- and long-term adverse effects on the mother and the offspring, no medicine is generally prescribed to prevent GDM. The present systematic review and meta-analysis aimed to investigate the effect of inositol supplementation in preventing GDM and related outcomes. Systematic search was performed in CENTRAL, MEDLINE, and Embase until 13 September 2023. Eligible randomized controlled trials (RCTs) compared the efficacy of inositols to placebo in pregnant women at high risk for GDM. Our primary outcome was the incidence of GDM, whereas secondary outcomes were oral glucose tolerance test (OGTT) and maternal and fetal complications. (PROSPERO registration number: CRD42021284939). Eight eligible RCTs were identified, including the data of 1795 patients. The incidence of GDM was halved by inositols compared to placebo (RR = 0.42, CI: 0.26?0.67). Fasting, 1-h, and 2-h OGTT glucose levels were significantly decreased by inositols. The stereoisomer myoinositol also reduced the risk of insulin need (RR = 0.29, CI: 0.13?0.68), preeclampsia or gestational hypertension (RR = 0.38, CI: 0.2?0.71), preterm birth (RR = 0.44, CI: 0.22?0.88), and neonatal hypoglycemia (RR = 0.12, CI: 0.03?0.55). Myoinositol decrease the incidence of GDM in pregnancies high-risk for GDM. Moreover, myoinositol supplementation reduces the risk of insulin need, preeclampsia or gestational hypertension, preterm birth, and neonatal hypoglycemia. Based on the present study 2?4 g myoinositol canbe suggested from the first trimester to prevent GDM and related outcomes.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk GDM inositol preterm birth neonatal maternal health gestational hypertension preeclampsia
Megjelenés:	Nutrients. - 15 : 19 (2023), p. 1-16. -
További szerzők:	Váncsa Szilárd Váradi Alex (1991-) (biológus) Szinte Julia Park, Sunjune Hegyi Péter Jenő (belgyógyász) Nyirády Péter Ács Nándor Horváth Eszter Mária Várbíró Szabolcs
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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