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001-es BibID:	BIBFORM116102
035-os BibID:	(Scopus)85164401622 (WOS)001017815400001
Első szerző:	Banach, Maciej
Cím:	Regional differences in physicians' behavior and factors influencing the intensity of PCSK9 inhibitor therapy with alirocumab : a subanalysis of the ODYSSEY APPRISE study / Banach Maciej, Lewek Joanna, Pol Kaja, Rabczenko Daniel, Balanescu Serban M., Blaha Vladimir, Ceska Richard, Jankowski Piotr, Surma Stanisaw, Kolovou Genovefa, Liberopoulos Evangelos, Mitu Florin, Mitu Magda, Naji Franjo Husam, Paragh Gyorgy, Popawska Magdalena, Vrablik Michal, Pella Daniel
Dátum:	2023
ISSN:	2297-055X
Megjegyzések:	BackgroundDespite better accessibility of the effective lipid-lowering therapies, only about 20% of patients at very high cardiovascular risk achieve the low-density lipoprotein cholesterol (LDL-C) goals. There is a large disparity between European countries with worse results observed for the Central and Eastern Europe (CEE) patients. One of the main reasons for this ineffectiveness is therapeutic inertia related to the limited access to appropriate therapy and suitable dosage intensity. Thus, we aimed to compare the differences in physicians' therapeutic decisions on alirocumab dose selection, and factors affecting these in CEE countries vs. other countries included in the ODYSSEY APPRISE study.MethodsODYSSEY APPRISE was a prospective, single-arm, phase 3b open-label (& GE;12 weeks to & LE;30 months) study with alirocumab. Patients received 75 or 150 mg of alirocumab every 2 weeks, with dose adjustment during the study based on physician's judgment. The CEE group in the study included Czechia, Greece, Hungary, Poland, Romania, Slovakia, and Slovenia, which we compared with the other nine European countries (Austria, Belgium, Denmark, Finland, France, Germany, Italy, Spain, and Switzerland) plus Canada.ResultsA total of 921 patients on alirocumab were involved [modified intention-to-treat (mITT) analysis], including 114 (12.4%) subjects from CEE countries. Therapy in CEE vs. other countries was numerically more frequently started with lower alirocumab dose (75 mg) at the first visit (74.6 vs. 68%, p = 0.16). Since week 36, the higher dose was predominantly used in CEE patients (150 mg dose in 51.6% patients), which was maintained by the end of the study. Altogether, alirocumab dose was significantly more often increased by CEE physicians (54.1 vs. 39.9%, p = 0.013). Therefore, more patients achieved LDL-C goal at the end of the study (<55 mg/dl/1.4 mmol/L and 50% reduction of LDL-C: 32.5% vs. 28.8%). The only factor significantly influencing the decision on dose of alirocumab was LDL-C level for both countries' groups (CEE: 199.2 vs. 175.3 mg/dl; p = 0.019; other: 205.9 vs. 171.6 mg/dl; p < 0.001, for 150 and 75 mg of alirocumab, respectively) which was also confirmed in multivariable analysis (OR = 1.10; 95% CI: 1.07-1.13).ConclusionsDespite larger unmet needs and regional disparities in LDL-C targets achievement in CEE countries, more physicians in this region tend to use the higher dose of alirocumab, they are more prone to increase the dose, which is associated with a higher proportion of patients reaching LDL-C goals. The only factor that significantly influences decision whether to increase or decrease the dose of alirocumab is LDL-C level.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Cardiovascular Medicine. - 10 (2023), p. 1-9. -
További szerzők:	Lewek, Joanna Pol, Kaja Rabczenko, Daniel Balanescu, Serban M. Blaha, Vladimir Ceska, Richard Jankowski, Piotr Surma, Stanisaw Kolovou, Genovefa Liberopoulos, Evangelos Mitu, Florin Mitu, Magda Naji, Franjo Husam Paragh György (1953-) (belgyógyász) Popawska, Magdalena Vrablík, Michal Pella, Daniel
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM106314
035-os BibID:	(cikkazonosító)1081986 (Scopus)85146987410 (WoS)000917668200001
Első szerző:	Kovács Beáta (belgyógyász)
Cím:	Determining the prevalence of childhood hypertension and its concomitant metabolic abnormalities using data mining methods in the Northeastern region of Hungary / Beáta Kovács, Ákos Németh, Bálint Daróczy, Zsolt Karányi, László Maroda, Ágnes Diószegi, Bíborka Nádró, Tamás Szabó, Mariann Harangi, Dénes Páll
Dátum:	2023
ISSN:	2297-055X
Megjegyzések:	Objective: Identifying hypertension in children and providing treatment for it have a marked impact on the patients' long-term cardiovascular outcomes. The global prevalence of childhood hypertension is increasing, yet its investigation has been rather sporadic in Eastern Europe. Therefore, our goal was to determine the prevalence of childhood hypertension and its concomitant metabolic abnormalities using data mining methods. Methods: We evaluated data from 3 to 18-year-old children who visited the University of Debrecen Clinical Center's hospital throughout a 15-year study period (n = 92,198; boys/girls: 48/52%). Results: We identified a total of 3,687 children with hypertension (2,107 boys and 1,580 girls), with a 4% calculated prevalence of hypertension in the whole study population and a higher prevalence in boys (4.7%) as compared to girls (3.2%). Among boys we found an increasing prevalence in consecutive age groups in the study population, but among girls the highest prevalences are identified in the 12-15-year age group. Markedly higher BMI values were found in hypertensive children as compared to non-hypertensives in all age groups. Moreover, significantly higher total cholesterol (4.27 ? 0.95 vs. 4.17 ? 0.88 mmol/L), LDL-C (2.62 ? 0.79 vs. 2.44 ? 0.74 mmol/L) and triglyceride (1.2 (0.85-1.69) vs. 0.94 (0.7-1.33) mmol/L), and lower HDL-C (1.2 ? 0.3 vs. 1.42 ? 0.39 mmol/L) levels were found in hypertensive children. Furthermore, significantly higher serum uric acid levels were found in children with hypertension (299.2 ? 86.1 vs. 259.9 ? 73.3 ?mol/L), while glucose levels did not differ significantly. Conclusion: Our data suggest that the calculated prevalence of childhood hypertension in our region is comparable to data from other European countries and is associated with early metabolic disturbances. Data mining is an effective method for identifying childhood hypertension and its metabolic consequences.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk adolescents blood pressure children data mining hypertension metabolic parameters obesity prevalence
Megjelenés:	Frontiers in Cardiovascular Medicine. - 9 (2023), p. 1-10. -
További szerzők:	Németh Ákos (1984-) (gyógyszer-vegyészmérnök, közgazdász) Daróczy Bálint (1984-) (informatikus, matematikus) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Maroda László (1979-) (gyógyszerész) Diószegi Ágnes (1987-) (belgyógyász) Nádró Bíborka (1992-) (általános orvos) Szabó Tamás (1968-) (gyermekgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Páll Dénes (1967-) (belgyógyász, kardiológus)
Pályázati támogatás:	K142273 OTKA MTA Premium Postdoctoral Fund MTA European Union Project RRF-2.3.1-21-2022-00004 Egyéb
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