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001-es BibID:BIBFORM061613
Első szerző:George, Eric M. (tudományos segédmunkatárs)
Cím:Induction of Heme Oxygenase-1 Attenuates Placental Ischemia-Induced Hypertension / Eric M. George, Kathy Cockrell, Marietta Arany, Eva Csongradi, David E. Stec, Joey P. Granger.
Dátum:2010
ISSN:0194-911X
Megjegyzések:Preeclampsia commonly presents as hypertension and proteinuria after the twentieth week of pregnancy. Recently, it has been recognized that the underlying mechanism in the pathophysiology of the disease is placental insufficiency and ischemia. Two mechanisms believed to be involved are the imbalance of the pro- and anti-angiogenic proteins VEGF and sFlt-1, and the production of ROS in the ischemic placenta. Heme oxygenase-1 (HO-1), a factor in the heme salvage pathway, has been shown to have beneficial effects in several models of hypertension, presumably through the production of biologically active byproducts; the vasodilatory molecule CO and the antioxidant bilirubin. Here we have utilized a rat reduced uterine perfusion pressure (RUPP) model of placental ischemia to determine if HO-1 could have beneficial effects on the disease pathology. At day 19 of pregnancy, RUPP rats showed significantly higher blood e90 Hypertension Vol 56, No 5 November 2010 Downloaded from http://hyper.ahajournals.org/ by guest on December 13, 2015 pressure than controls (1367mmHg vs. 1055mmHg respectively). Induction of HO-1 by administration of cobalt protoporphyrin (COPP) significantly reduced MAP in RUPP rats but not controls (1188 and 1045mmHg respectively). Intriguingly, normalized placental sFlt-1/ VEGF ratio, which is significantly elevated in the RUPP model versus controls (1.24.2 and 11 respectively), is significantly reduced in response to HO-1 induction (0.69.1), indicating a more pro-angiogenic phenotype. Finally, placental ROS production which is elevated nearly 4-fold in RUPP rats (953279 vs. 24471 RLU/min/mg) is significantly attenuated, though not normalized, by COPP administration (617225 RLU/min/mg). Collectively, these results suggest that induction of HO-1 or one of its biologically active metabolites might be a candidate for therapeutic intervention in preeclampsia
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
Megjelenés:Hypertension 56 : 5 (2010), p. e90. -
További szerzők:Cockrell, Kathy (tudományos segédmunkatárs) Arany Marietta Csongrádi Éva (1969-) (szakorvos) Stec, David E. Granger, Joey P. (tudományos segédmunkatárs)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM036274
Első szerző:Lőcsey Lajos (belgyógyász, nephrológus)
Cím:Relationship between augmentation index, pulse wave velocity in metabolic alterations after renal transplantation / Locsey L., Borbas B., Szlanka B., Menes I., Szabo L., Mazurka B., Asztalos L., Lorincz I.
Dátum:2006
ISSN:0263-6352
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Journal of Hypertension. - 24 : Suppl. 4 (2006), p. S103. -
További szerzők:Borbás Béla Szlanka Beatrix Ménes István Szabó L. Mazurka B. Asztalos László (1951-) (sebész) Lőrincz István (1950-) (belgyógyász, kardiológus)
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3.

001-es BibID:BIBFORM069079
Első szerző:Páll Dénes (belgyógyász, kardiológus)
Cím:Assessment of target-organ damage in adolescent white coat and sustained hypertension / Pall Denes, Katona Eva, Zrinyi Miklós, Lengyel Szabolcs, Paragh Gyorgy, Fulesdi Bela
Dátum:2016
ISSN:0263-6352
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Journal Of Hypertension 34 (2016), p. e243. -
További szerzők:Katona Éva (1967-) (belgyógyász, diabetológus) Zrínyi Miklós (1969-) (közgazdász) Lengyel Szabolcs (1981-) (belgyógyász) Paragh György (1953-) (belgyógyász) Fülesdi Béla (1961-) (aneszteziológus)
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4.

001-es BibID:BIBFORM025490
Első szerző:Páll Dénes (belgyógyász, kardiológus)
Cím:Blood pressure distribution in a Hungarian adolescent population : comparison with normal values in the USA / Dénes Páll, Éva Katona, Béla Fülesdi, Miklós Zrínyi, János Zatik, Dániel Bereczki, Péter Polgár, György Kakuk
Dátum:2003
Megjegyzések:To describe the blood pressure characteristics and distribution of all adolescent high school students (aged 15-18 years) in Debrecen (total population 230 000), Hungary. To define threshold values for normal blood pressure by age-, sex- and height-specific groups. To compare our data with results from a USA meta-analysis, which forms the basis of current guidelines. PARTICIPANTS AND METHODS: All young people attending high school in Debrecen (final sample = 10 359) participated in the study. After they had rested for 10 min, three blood pressure measurements were taken from the right upper arm, separated by 5 min intervals. All measurements were obtained by a validated, automated, digital Omron M4 device. RESULTS: The 50th, 90th and 95th percentile values of blood pressure were defined by dividing the adolescent population into age-, sex- and height-specific subgroups. In comparison with USA guidelines, in our sample the systolic blood pressure of boys in the different subgroups was 6-11 mmHg greater, whereas this difference was less marked for girls (1-5 mmHg). There were no marked differences in diastolic blood pressure, but our values were slightly lower. CONCLUSIONS: Our findings demonstrate the influence of geographical and ethnic variations on blood pressure. Acceptance and use of non-population-specific blood pressure distributions may lead to under- or overdiagnosis of adolescent hypertension. The use of geographically more relevant data should be encouraged.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of hypertension. - 21 : 1 (2003), p. 41-47. -
További szerzők:Katona Éva (1967-) (belgyógyász, diabetológus) Fülesdi Béla (1961-) (aneszteziológus) Zrínyi Miklós (1969-) (közgazdász) Zatik János (1961-) (szülész-nőgyógyász) Bereczki Dániel (1960-) (neurológus) Polgár Péter Kakuk György (1938-2018) (belgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM061612
Első szerző:Stec, David E.
Cím:Thick Ascending Loop of Henle (talh) Specific Expression of Ho-1 Attenuates the Development of Ang II-Dependent Hypertension / David E. Stec, Eva Csongradi, Trinity Vera, Heather A. Drummond, Nader G. Abraham
Dátum:2010
ISSN:0194-911X
Megjegyzések:Recent studies have demonstrated an important antihypertensive action of renal heme oxygenase-1 (HO-1) induction; however, the specific contribution of thick ascending loop of Henle (TALH) derived HO-1 to this response is unknown. We generated a transgenic mouse model in which expression of the human HO-1 cDNA was controlled by the uromodulin (Tamm-Horsfall protein, THP) promoter (TALH-HHO1). Expression of the HO-1 transgene was only detected in isolated microdissected TALH tubule segments by rt-PCR. TALH-HHO1 mice exhibited a significant increase in medullary HO-1 protein which co-localized with endogenous THP protein as determined by confocal microscopy. HO activity was significantly increased in the medulla of TALH-HHO1 mice as compared to controls (25?7 vs. 151 30 pmoles/bilirubin/ mg/hr, n=6, p0.05), however, no difference in cortical HO activity was observed between TALH-HHO1 and non-transgenic mice. The effect of enhanced TALH HO-1 on the blood pressure response to increased Angiotensin II (Ang II) was determined in mice in which Ang II (1 g/min/kg. s.c.) was infused via an osmotic minipump for 10 days. Conscious blood pressures were measured over the last five days using implanted catheters. Ang II hypertension was significantly attenuated in TALH-HHO1 mice as compared to non-transgenic mice and averaged 139?3 vs. 153?2 mmHg (n=5, p0.05) in each group respectively. The decrease in blood pressure in TALH-HHO1 transgenic mice was associated with a 60% decrease in the level of the NKCC2 transporter in the medulla as determined by Western blot. TALH-HHO1 mice also exhibited a 36% decrease in sodium reabsorption measure in isolated TAHL tubule segments by ouabain sensitive rubidium (Rb) uptake. Our results demonstrate that increased levels of HO-1 in the TALH can lower blood pressure via a mechanism that may include alterations in NKCC2 dependent sodium reabsorption.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
Megjelenés:Hypertension 56 : 5 (2010), p. e60. -
További szerzők:Csongrádi Éva (1969-) (szakorvos) Vera, Trinity Drummond, Heather A. Abraham, Nader G. (tudományos segédmunkatárs)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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