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001-es BibID:	BIBFORM050620
Első szerző:	Barta Kitti (belgyógyász)
Cím:	Hemodiafiltration beneficially affects QT interval duration and dispersion compared to hemodialysis / Kitti Barta, Árpád Czifra, Csaba Kun, Alida Páll, Julianna Kulcsár, György Paragh, István Lőrincz, Tamás János Padra, Anupam Agarwal, Zarjou Abolfazl, József Balla, Zoltán Szabo
Dátum:	2014
ISSN:	1342-1751 1437-7799
Megjegyzések:	BACKGROUND/AIMS:The prolongation of the QT interval and dispersion could predict ventricular arrhythmias. It is not yet established whether there is a difference between the effects of hemodialysis and hemodiafiltration on QT interval duration and dispersion.METHODS:Data of thirty patients was investigated while they were receiving hemodiafiltration over a period of 3 months; then the same group of patients was evaluated during treatment with conventional hemodialysis for at least another 3 months. Ionic parameters and surface electrocardiograms (ECG) were analyzed five times during each session, and 2D, M-mode echocardiography and Holter ECGs were performed to acquire additional information.RESULTS:QT interval duration (QTmax) and dispersion (QTd) showed a significant increase during hemodialysis, but not during hemodiafiltration. QTmax was 388.66 ? 31.81 ms at the beginning of hemodialysis and increased to 400.66 ? 39.12 ms even at the 30th minute (p < 0.05). QTd was found to be 31.33 ? 10.08 ms before the commencement of hemodialysis with the largest prolongation being seen at the 240th minute (51.33 ? 14.56 ms, p < 0.05). The occurrence of ventricular premature beats was significantly higher during hemodialysis (p = 0.018). The left atrial diameter significantly decreased at the end of hemodiafiltration (at the beginning 45.1 ? 5.25 mm, at the end 40.77 ? 5.76 mm; p < 0.05).CONCLUSION:Our results suggest a beneficial effect of hemodiafiltration on the studied electrocardiographic parameters compared to hemodialysis. The larger decrease in the left atrial diameter suggests a more efficient intracardiac volume-decreasing potential of hemodiafiltration.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Hemodiafiltration Hemodialysis Ventricular arrhythmias QT interval QT dispersion
Megjelenés:	Clinical and Experimental Nephrology. - 18 : 6 (2014), p. 952-959. -
További szerzők:	Czifra Árpád (1983-) (belgyógyász) Kun Csaba (1969-) (kardiológus) Páll Alida (1983-) (orvos) Kulcsár Júlia (1983-) (orvos) Paragh György (1953-) (belgyógyász) Lőrincz István (1950-) (belgyógyász, kardiológus) Padra János Tamás (1984-) (biológus) Agarwal, Anupam Zarjou, Abolfazl (1979-) (kutató orvos) Balla József (1959-) (belgyógyász, nephrológus) Szabó Zoltán (1973-) (belgyógyász, kardiológus)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0045 TÁMOP Belgyógyászat Kutatócsoport
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001-es BibID:	BIBFORM027923
Első szerző:	Buglyó Gergely (genetikus)
Cím:	WT1 microdeletion and slowly progressing focal glomerulosclerosis in a patient with male pseudohermaphroditism, childhood leukemia, Wilms tumor and cerebellar angioblastoma / Gergely Buglyó, Gábor Méhes, György Vargha, Sándor Biró, János Mátyus
Dátum:	2013
ISSN:	0301-0430
Megjegyzések:	The WT1 gene is currently in focus by pediatric nephrologists as its mutations are associated with nephrotic syndrome, especially as part of complex clinical entities like Denys-Drash or Frasier syndrome. Renal failure may also develop in young WAGR patients, whose condition is attributed to a deletion at chromosomal region 11p13. However, only limited data exist on WT1 microdeletions. A 30-year-old male patient, with a history of genital malformations, a Wilms tumor manifested during the treatment of ALL at an age of 4, and a cerebellar angioblastoma, was referred with proteinuria and a reduced GFR. Kidney biopsy revealed FSGS. Although all WT1 exons were amplified with PCR and sequenced, none of them showed a mutation. However, an FFPE tissue sample of the patient's childhood Wilms tumor showed WT1-positivity restricted to the renal tumor cells, so the WT1 gene was investigated further. Using qRT-PCR, the gene was found to be present in only one copy in the patient's genomic DNA sample, while both copies were detected in both parents. In the patient's sister, the proximal region of WT1 was shown to have an extra copy. Evidence suggests that a heterozygous microdeletion of the gene WT1 is responsible for the patient's disease. It seems reasonable to assume a possible abnormality affecting meiotic crossing over at the WT1 locus in one of the parents.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Clinical Nephrology 79 : 5 (2013), p. 414-418. -
További szerzők:	Méhes Gábor (1966-) (patológus) Vargha György (1951-) (orvos) Biró Sándor (1949-) (molekuláris genetikus) Mátyus János (1957-) (belgyógyász, nephrológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL DOI
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001-es BibID:	BIBFORM002293
Első szerző:	Sulowicz, Wladyslaw
Cím:	Once-Monthly subcutaneous C.E.R.A. maintains stable hemoglobin control in patients with chronic kidney disease on dialysis and converted directly from epoetin one to three times weekly / Wladyslaw Sulowicz, Francesco Locatelli, Jean-Philippe Ryckelynck, Jozsef Balla, Botond Csiky, Kevin Harris, Patricia Ehrhard, Ulrich Beyer
Dátum:	2007
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Clinical journal of the American Society of Nephrology : CJASN 2 : 4 (2007), p. 637-646. -
További szerzők:	Locatelli, Francesco Ryckelynck, Jean-Philippe Balla József (1959-) (belgyógyász, nephrológus) Csiky Botond Harris, Kevin Ehrhard, Patricia Beyer, Ulrich
Internet cím:	elektronikus változat DOI
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001-es BibID:	BIBFORM040399
Első szerző:	Vas T.
Cím:	Oxidative stress and non-enzymatic glycation in IgA nephropathy / Vas T., Wagner Z., Jenei V., Varga Z., Kovács T., Wittmann I., Schinzel R., Balla G., Balla J., Heidland A., Nagy J.
Dátum:	2005
ISSN:	0301-0430
Megjegyzések:	AIM: Approximately 20-50% of IgA nephropathy patients develop end-stage renal disease. We have previously found enhanced oxidative stress and decreased antioxidant capacity in red blood cells of IgA nephropathy patients. In this study we assess oxidative stress, non-enzymatic glycation, oxidative resistance of low-density lipoprotein and its alpha-tocopherol content in these patients. PATIENTS AND METHODS: Non-enzymatic glycation and oxidative stress were assessed in 88 IgA nephropathy patients by measuring advanced glycation end products, Nepsilon-carboxymethyl-lysine, thiobarbituric acid reactive substances, oxidative resistance of low-density lipoprotein and its alpha-tocopherol content. RESULTS: Advanced glycation end products (2659 +/- 958 a.u.) and Nepsilon-carboxymethyl-lysine (563 +/- 215 ng/ml) were significantly higher in IgA nephropathy patients with decreased renal function compared to those with normal renal function (p < 0.002) or controls (p < 0.001). Thiobarbituric acid-reactive substances in plasma and associated with low-density lipoprotein were significantly elevated and oxidative resistance of low-density lipoprotein was significantly reduced in all groups of IgA nephropathy patients. There was no significant difference in circulating fluorescent advanced glycation end products, Nepsilon-carboxymethyl-lysine, thiobarbituric acid-reactive substances levels, oxidative resistance of low-density lipoprotein and its alpha-tocopherol content between patients with normal vs. impaired glucose metabolism. Low alpha-tocopherol content of low-density lipoprotein was accompanied with decreased oxidative resistance, depletion in polyunsaturated fatty acids, elevated saturated fatty acids and thiobarbituric acid-reactive substances within low-density lipoprotein suggesting enhanced lipid peroxidation. CONCLUSIONS: Decreased oxidative resistance of low-density lipoprotein and enhanced oxidative stress are common features in IgA nephropathy, while increased non-enzymatic glycation occurs as renal function declines.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Clinical Nephrology. - 64 : 5 (2005), p. 343-351. -
További szerzők:	Wagner Zoltán Jeney Viktória (1971-) (vegyész, kémia tanár) Varga Z. Kovács T. Wittmann István Schinzel, R. Balla György (1953-) (csecsemő és gyermekgyógyász, neonatológus) Balla József (1959-) (belgyógyász, nephrológus) Heidland, A. Nagy J. (orvos)
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