Találati lista | Tudóstér

001-es BibID:	BIBFORM036331
Első szerző:	Kovács Márta
Cím:	Pancreatic autoantibodies and autoantibodies against goblet cells in pediatric patients with inflammatory bowel disease (IBD) / Kovacs Marta, Lakatos Peter Laszlo, Papp Maria, Jacobsen Silvia, Nemes Eva, Polgar Marianne, Solyom Eniko, Bodi Piroska, Horvath Agnes, Muller Katalin Eszter, Molnar Kriszta, Szabo Doloresz, Cseh Aron, Dezsofi Antal, Arato Andras, Veres Gabor
Dátum:	2012
ISSN:	0277-2116
Megjegyzések:	Significance of pancreatic autoantibodies determined by using exocrine pancreas (PAB) and recombinant pancreas antigens (rPAB), as well as importance of autoantibodies against goblet cells (GAB) are not known in pediatric patients with inflammatory bowel disease (IBD). Our aim was to determine the complex analysis of PAB, rPAB, GAB, antibodies against Saccharomyces cerevisiae (ASCA), and perinuclear components of neutrophils (pANCA) in pediatric IBD patients. Moreover, association with NOD2/CARD15 and disease phenotype was determined. METHODS: 152 pediatric patients (median age 13.9 years) with IBD [103 patients with Crohn's disease (CD) and 49 patients with ulcerative colitis (UC)] and 104 controls were included. Serum autoantibodies were determined by indirect immunofluorescens assay. NOD2/CARD15 variants were tested by polymerase chain reaction/restriction fragment length polymorphism. RESULTS: The presence of PAB and rPAB was significantly higher in CD (34% and 35.9%) and in UC (20.4% and 24.5%) compared to pediatric control cohort (0% and 0%, p < 0.0001). In addition, GAB positivity was significantly increased in patients with UC in comparison to CD and controls, respectively (UC, 12.2%, CD, 1.9%, controls, 1.9%, p=0.02). Specificity of PAB and rPAB was 100%, however, sensitivity was low. The combination of PAB and/or ASCA/pANCA improved the sensitivity of serological markers in CD (87.4%) and in UC (79.6%); specificities were 89.3% and 93.2%, respectively. Pancreatic autoantibodies (PAB, rPAB) and GAB were not related to clinical presentation, medical therapy or need for surgery in CD or in UC. CONCLUSIONS: Pancreatic autoantibodies and GAB were specific for IBD but the sensitivity was limited as well as there was lack of correlation with clinical phenotype. Combinations of these antibodies have shown increased sensitivity, therefore, it may be recommended in the diagnostic procedure of IBD.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Pediatric Gastroenterology And Nutrition 55 : 4 (2012), p. 429-435. -
További szerzők:	Lakatos Péter (Semmelweis Egyetem) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Jacobsen, Silvia Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) Polgár Marianna Sólyom Enikő Bodi Piroska Horváth Ágnes (Veszprém) Müller Katalin Eszter Molnár Kriszta Szabó Dolóresz Cseh Áron Dezsőfi Antal Arató András Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon:

001-es BibID:	BIBFORM059588
Első szerző:	Müller Katalin Eszter
Cím:	Baseline Characteristics and Disease Phenotype In Inflammatory Bowel Disease / Müller Katalin E., Lakatos Peter L., Kovacs Judit B., Arato Andras, Varkonyi Agnes, Nemes Eva, Tarnok Andras, Toth Gergely, Papp Maria, Solyom Eniko, Horvath Agnes, Guthy Ildiko, Kovacs Marta, Hungarian IBD Registry Group (HUPIR) and Veres Gabor
Dátum:	2016
ISSN:	0277-2116
Megjegyzések:	Background and Aims: Predicting short-term relapses and long-term prognosis is of outmost importance in paediatric inflammatory bowel disease. Our aim was to investigate the short-term disease outcome and medication during the first year in a paediatric incident cohort from Hungary. In addition, association laboratory markers and disease activity indices with short-term disease outcome and medication were analysed.Methods: From January 1, 2008 to December 31, 2010 demographic data and clinical characteristics of newly diagnosed paediatric inflammatory bowel disease patients younger than 18 years of age were prospectively recorded.Results: A total of 420 patients were identified [Crohn's disease: 266; ulcerative colitis 124]. Initially, 48% (124/256) of Crohn's disease patients had moderate to severe disease (PCDAI>31), and this rate decreased to 2.1% at one-year follow-up. Proportion of ulcerative colitis patients with moderate to severe disease (PUCAI>35) at diagnosis declined from 57.5% (69/120) to 6.8% at one-year follow-up. Terminal ileal involvement correlated with higher initial CRP (p = 0.021) and initial PCDAI (p = 0.026). In ulcerative colitis, elevated CRP (p = 0.002) was associated with disease extension. CRP and PCDAI at diagnosis were associated with the need for immunomodulators at one year in children with Crohn's disease. Initial CRP was also associated with the need for immunomodulators in patients with ulcerative colitis at one-year follow-up.Conclusions: At diagnosis half of the patients with inflammatory bowel disease had moderate to severe disease and this rate decreased to less than 10% after one year. Initial CRP and PCDAI were related to the need for aggressive therapy in Crohn's disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban pediatric inflammatory bowel disease epidemiology therapy disease activity index CRP follow-up
Megjelenés:	Journal Of Pediatric Gastroenterology And Nutrition 62 : 1 (2016), p. 50-55. -
További szerzők:	Lakatos Péter (Semmelweis Egyetem) Kovács Judit B. Arató András Várkonyi Ágnes Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) Tárnok András Tóth Gergely Papp Mária (1975-) (belgyógyász, gasztroenterológus) Sólyom Enikő Horváth Ágnes (Veszprém) Guthy Ildikó Kovács Márta Veres Gábor (orvos) Hungarian IBD Registry Group (HUPIR)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM047226
Első szerző:	Müller Katalin Eszter
Cím:	Incidence, paris classification and follow-up in a nationwide, incident cohort of pediatric patients with inflammatory bowel disease / Katalin E. Müller, Péter L. Lakatos, András Arató, Judit B. Kovács, Ágnes Várkonyi, Dániel Szűcs, Erzsébet Szakos, Enikő Sólyom, Márta Kovács, Marianne Polgár, Éva Nemes, Ildikó Guthy, István Tokodi, Gergely Tóth, Ágnes Horváth, András Tárnok, Noémi Csoszánszki, Márta Balogh, Noémi Vass, Piroska Bódi, Antal Dezsőfi, László Gárdos, Éva Micskey, Mária Papp, Áron Cseh, Dolóresz Szabó, Péter Vörös, Hungarian IBD Registry Group (HUPIR), Gabor Veres
Dátum:	2013
ISSN:	0277-2116
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Pediatric Gastroenterology and Nutrition 57 : 5 (2013), p. 576-582. -
További szerzők:	Lakatos Péter (Semmelweis Egyetem) Arató András Kovács Judit B. Várkonyi Ágnes Szűcs Dániel Szakos Erzsébet Sólyom Enikő Kovács Márta Polgár Marianna Nemes Éva (1957-) (csecsemő- és gyermekgyógyász, gasztroenterológus) Guthy Ildikó Tokodi István Tóth Gergely Horváth Ágnes (Veszprém) Tárnok András Csoszánszky Noémi Balogh Márta Vass Noémi Bodi Piroska Dezsőfi Antal Gardos László Micskey Éva Papp Mária (1975-) (belgyógyász, gasztroenterológus) Cseh Áron Szabó Dolóresz Vörös Péter (agrár) Veres Gábor (orvos) Hungarian IBD Registry Group (HUPIR)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: