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001-es BibID:	BIBFORM002765
Első szerző:	Petrovski, Goran (orvos)
Cím:	Clearance of dying autophagic cells of different origin by professional and non-professional phagocytes / Petrovski G., Zahuczky G., Katona K., Vereb G., Martinet W., Nemes Z., Bursch W., Fesus L.
Dátum:	2007
Megjegyzések:	MCF-7 cells undergo autophagic death upon tamoxifen treatment. Plated on non-adhesive substratum these cells died by anoikis while inducing autophagy as revealed by monodansylcadaverine staining, elevated light-chain-3 expression and electron microscopy. Both de novo and anoikis-derived autophagic dying cells were engulfed by human macrophages and MCF-7 cells. Inhibition of autophagy by 3-methyladenine abolished engulfment of cells dying through de novo autophagy, but not those dying through anoikis. Blocking exposure of phosphatidylserine (PS) on both dying cell types inhibited phagocytosis by MCF-7 but not by macrophages. Gene expression profiling showed that though both types of phagocytes expressed full repertoire of the PS recognition and signaling pathway, macrophages could evolve during engulfment of de novo autophagic cells the potential of calreticulin-mediated processes as well. Our data suggest that cells dying through autophagy and those committing anoikis with autophagy may engage in overlapping but distinct sets of clearance mechanisms in professional and non-professional phagocytes
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Apoptosis Biophysics Cells Gene Expression Human Hungary Macrophages Microscopy Phagocytosis Research Support
Megjelenés:	Cell Death Differentiation. - 14 : 6 (2007), p. 1117-1128. -
További szerzők:	Zahuczky Gábor (1975-) (molekuláris biológus, biokémikus, vegyész) Katona Klára (1976-) Vereb György (1965-) (biofizikus, orvos) Martinet, Wim Nemes Z. Bursch, Wilfried Fésüs László (1947-) (orvos biokémikus)
Internet cím:	DOI elektronikus változat
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001-es BibID:	BIBFORM001532
Első szerző:	Sarang Zsolt (mikrobiológus)
Cím:	Tissue transglutaminase (TG2) facilitates phosphatidylserine exposure and calpain activity in calcium-induced death of erythrocytes : letter to editor / Z. Sarang, A. Mádi, C. Koy, S. Varga, M. O. Glocker, D. S. Ucker, S. Kuchay, A. H. Chishti, G. Melino, L. Fésüs, Z. Szondy
Dátum:	2007
Tárgyszavak:	Orvostudományok Elméleti orvostudományok szerkesztői levél
Megjelenés:	Cell Death and Differentiation 14 : 10 (2007), p. 1842-1844. -
További szerzők:	Mádi András (1967-) (biológus) Koy, Cornelia Varga Sándor (1943-) (biofizikus) Glocker, Michael O. Ucker, D. S. Kuchay, S. Chishti, A. H. Melino, Gerry Fésüs László (1947-) (orvos biokémikus) Szondy Zsuzsanna (1959-) (molekuláris sejtbiológus, biokémikus)
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001-es BibID:	BIBFORM006074
035-os BibID:	(WOS)A1996UT34700012
Első szerző:	Szabó Gábor (biofizikus)
Cím:	Chromatin isolated from viable human PBLs contains DNA fragmented to >=50kb / Szabo, G., Bacso, Z.
Dátum:	1996
Megjegyzések:	Massive chromatin fragmentation (around 50 kb, to several hundred kb) is observed in nuclear lysates of human peripheral blood lymphocytes (PBLs) upon their treatment with nuclease-free protein-denaturants. There is a consistent variation in the fragment size distributions that parallels the proliferative activity of the cells. Predominantly approximately 50 kb fragmentation is exhibited in samples from cells immunsuppressed via CD4 crosslinking, as opposed to the heterogeneous, higher molecular weight DNA of anti-TcR/CD3-, phytohemagglutininor concanavalin A-stimulated cells. Tritiated thymidine incorporated into DNA in the latter cultures can be detected in the approximately 50 kb band. Direct lysis of agarose-embedded, live cells in alkali+detergent also yields fragmented DNA, with a single-strand size of >/=50 kb. These data suggest that (i) the cells yielding fragmented DNA were alive at the time of DNA extraction, (ii) either regularly arranged, preformed nicks or hypersensitive sites may be present at every roughly 50-100 kb in the chromatin of PBLs, (iii) these sites or the fragmentation mechanism acting upon them, appear to be regulated in concert with the transit of cells between the resting and proliferative compartments.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Biophysics blood Cells Chromatin Dna Human Hungary Lymphocytes Molecular Weight Thymidine egyetemen (Magyarországon) készült közlemény
Megjelenés:	Cell Death and Differentiation. - 3 : 2 (1996), p. 237-241. -
További szerzők:	Bacsó Zsolt (1963-) (biofizikus)
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