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1.

001-es BibID:BIBFORM029094
Első szerző:Antal Miklós (orvos, anatómus)
Cím:Expression of hyperpolarization-activated and cyclic nucleotide-gated cation channel subunit 2 in axon terminals of peptidergic nociceptive primary sensory neurons in the superficial spinal dorsal horn of rats / Antal, M., Papp, I., Bahaerguli, N., Veress, G., Vereb, G.
Dátum:2004
Megjegyzések:Hyperpolarization-activated cyclic nucleotide-gated cation channel proteins (HCN1-4), which are potentially able to modulate membrane excitability, are abundantly expressed by neurons in spinal dorsal root ganglia (DRG). In the present experiment, we investigated whether HCN2 protein is confined exclusively to the perikarya of DRG neurons or is transported from the somata to the central axons of DRG neurons that terminate in the spinal dorsal horn. Using immunohistochemical methods, we have demonstrated that laminae I-IIo of the superficial spinal dorsal horn of the adult rat spinal cord show a strong punctate immunoreactivity for HCN2. Dorsal rhizotomy resulted in a complete loss of immunostaining in the dorsal horn, suggesting that HCN2 is confined to axon terminals of primary afferents. In double labelling immunohistochemical studies, we have also shown that HCN2 widely co-localizes with calcitonin gene-related peptide, but is almost completely segregated from isolectin-B4 binding, indicating that HCN2 is primarily expressed in peptidergic nociceptive primary afferents. The expression of HCN2 in central terminals of peptidergic primary afferents was also verified with electron microscopy. Utilizing the pre-embedding nanogold method, we found that HCN2 is largely confined to axon terminals with dense-core vesicles. Within these terminals, some of the silver grains marking the accurate location of HCN2 molecules were associated with the cell membrane, and others were scattered in the axoplasm. Within the cell membrane, HCN2 was found almost exclusively in extrasynaptic locations. The results suggest that HCN2 may contribute to the modulation of membrane excitability of nociceptive primary afferent terminals in the spinal dorsal horn.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The European Journal of Neuroscience 19 : 5 (2004), p. 1336-1342. -
További szerzők:Papp Ildikó (1976-) (biológus) Bahaerguli, Niyazi Veress Gábor (1971-) (neurobiológus) Vereb György (1965-) (biofizikus, orvos)
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elektronikus változat
DOI
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2.

001-es BibID:BIBFORM040762
Első szerző:Batta József Tamás (fül-orr-gégész)
Cím:Regulation of the lateral wall stiffness by acetylcholine and GABA in the outer hair cells of the guinea pig / Batta T. J., Panyi Gy., Szucs A., Sziklai I.
Dátum:2004
ISSN:0953-816X
Megjegyzések:Acetylcholine (ACh) and GABA, the main neurotransmitters of the efferent innervation of the outer hair cells (OHCs), are assumed to regulate the efficacy of the cochlear amplifier through a variety of mechanisms. The recently described stretch-induced changes of the lateral wall stiffness (regulatory stiffness response) and the stretch-induced slow cell motility of OHCs may be important regulatory mechanisms in this process. We found that ACh in cochleobasal OHCs significantly reduces the stiffness of the lateral wall but increases the regulatory stiffness response and stretch-induced slow cell motility. Qualitatively similar cellular responses were evoked by GABA in cochleoapical OHCs. The effects of ACh could be inhibited by strychnine, the specific inhibitor of the alpha(9) ACh receptors expressed in OHCs, whereas the effects of GABA could be blocked by bicuculline, a specific GABA(A) receptor antagonist. In the absence of extracellular Ca(2+) the effects of ACh and GABA on the regulatory stiffness response were reduced, indicating the involvement of Ca(2+) in the control of this process. Based on our results we suggest that efferent innervation protects the organ of Corti against high sound intensities and supports adaptation by modification of the micromechanical properties of OHCs. This could be governed by ACh and GABA indirectly, via the potentiation of stretch-induced cell shortening in a Ca(2+)-dependent manner, rather than by a direct stiffness regulation-related mechanism.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal Of Neuroscience. - 20 : 12 (2004), p. 3364-3370. -
További szerzők:Panyi György (1966-) (biofizikus) Szűcs Attila (1970-) (fül-orr-gégész) Sziklai István (1954-) (fül-orr-gégész)
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3.

001-es BibID:BIBFORM050040
Első szerző:Bhattacharya, Anirban
Cím:Potentiation of inhibitory synaptic transmission by extracellular ATP in rat suprachiasmatic nuclei / Anirban Bhattacharya, Vojtech Vavra, Irena Svobodova, Zdena Bendova, Gyorgy Vereb, Hana Zemkova
Dátum:2013
Megjegyzések:The hypothalamic suprachiasmatic nuclei (SCN), the circadian master clock in mammals, releases ATP in a rhythm, but the role of extracellular ATP in the SCN is still unknown. In this study, we examined the expression and function of ATP-gated P2X receptors (P2XRs) in the SCN neurons of slices isolated from the brain of 16- to 20-day-old rats. Quantitative RT-PCR showed that the SCN contains mRNA for P2X 1-7 receptors and several G-protein-coupled P2Y receptors. Among the P2XR subunits, the P2X2 > P2X7 > P2X4 mRNAs were the most abundant. Whole-cell patch-clamp recordings from SCN neurons revealed that extracellular ATP application increased the frequency of spontaneous GABAergic IPSCs without changes in their amplitudes. The effect of ATP appears to be mediated by presynaptic P2X2Rs because ATPgammaS and 2MeS-ATP mimics, while the P2XR antagonist PPADS blocks, the observed enhancement of the frequency of GABA currents. There were significant differences between two SCN regions in that the effect of ATP was higher in the ventrolateral subdivision, which is densely innervated from outside the SCN. Little evidence was found for the presence of P2XR channels in somata of SCN neurons as P2X2R immunoreactivity colocalized with synapsin and ATP-induced current was observed in only 7% of cells. In fura-2 AM-loaded slices, BzATP as well as ADP stimulated intracellular Ca(2+) increase, indicating that the SCN cells express functional P2X7 and P2Y receptors. Our data suggest that ATP activates presynaptic P2X2Rs to regulate inhibitory synaptic transmission within the SCN and that this effect varies between regions.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adenosine
Adenosine Triphosphate
Animals
Animals,Newborn
article
Biophysical Phenomena
Brain
Calcium
Cells
Cells,Cultured
cytology
Dose-Response Relationship,Drug
drug effects
Excitatory Amino Acid Antagonists
EXPRESSION
gamma-Aminobutyric Acid
Gene Expression Regulation
genetics
In Vitro
Male
metabolism
Neural Inhibition
Neurons
Patch-Clamp Techniques
pharmacology
physiology
Platelet Aggregation
Platelet Aggregation Inhibitors
Purinergic Agents
Rats
Rats,Wistar
Receptors,Purinergic P2X
Research
Research Support
rna
RNA,Messenger
Sodium
Sodium Channel Blockers
Support
Suprachiasmatic Nucleus
Synaptic Potentials
Synaptic Transmission
Tetrodotoxin
Megjelenés:The Journal of Neuroscience. - 33 : 18 (2013), p. 8035-8044. -
További szerzők:Vavra, Vojtech Svobodova, Irena Bendova, Zdena Vereb György (1965-) (biofizikus, orvos) Zemkova, Hana
Internet cím:DOI
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4.

001-es BibID:BIBFORM077126
Első szerző:Juhász Tamás (biológus, orvosbiológus)
Cím:Pituitary adenylate cyclase activating polypeptide (pacap)-signalling promotes chondrogenesis : implication of calcineurin as a downstream target / Juhasz T., Matta Cs., Katona E., Somogyi Cs., Takacs R., Kolozsvari B., Csernoch László, Panyi Gy., Tóth Gábor, Reglődi Dóra, Tamas Andrea, Zakany R.
Dátum:2013
ISSN:0895-8696
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Neurosciences
Neurosciences & Neurology
Biochemistry & molecular biology
Neurosciences
Elméleti Orvostudományok
Megjelenés:Journal Of Molecular Neuroscience. - 51 : Suppl. 1 (2013), p. 229. -
További szerzők:Matta Csaba (1980-) (molekuláris biológus, genetikus, angol szakfordító) Katona Éva (1986-) (molekuláris biológus) Somogyi Csilla (1983-) (biológus, angol-magyar szakfordító) Takács Roland Ádám (1985-) (molekuláris biológus, biokémikus) Kolozsvári Bernadett (1982-) (molekuláris biológus, genetikus) Csernoch László (1961-) (élettanász) Panyi György (1966-) (biofizikus) Tóth Gábor (Szeged) Reglődi Dóra (Idegtudományok) Tamás Andrea (Idegtudomány) (Pécs) Zákány Róza (1963-) (anatómus-, kötőszövetbiológus)
Pályázati támogatás:CNK80709
OTKA
TÁMOP 4.2.1.B-10/2/KONV-2010-002
TÁMOP
TÁMOP 4.2.2.A-11/1/KONV-2012-0025
TÁMOP
TAMOP 4.2.2.A-11/1/KONV-2012-0024
TÁMOP
TAMOP 4.2.4.A/2- 11-1-2012-0001
TÁMOP
K104984
OTKA
Internet cím:Szerző által megadott URL
DOI
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5.

001-es BibID:BIBFORM075780
035-os BibID:(WoS)000442995700011 (Scopus)85052649921
Első szerző:Simándi Zoltán (Ph.D. hallgató, molekuláris biológus)
Cím:Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons / Zoltan Simandi, Krisztian Pajer, Katalin Karolyi, Tatiana Sieler, Lu-Lin Jiang, Zsuzsanna Kolostyak, Zsanett Sari, Zoltan Fekecs, Attila Pap, Andreas Patsalos, Gerardo Alvarado Contreras, Balint Reho, Zoltan Papp, Xiufang Guo, Attila Horvath, Greta Kiss, Zsolt Keresztessy, György Vámosi, James Hickman, Huaxi Xu, Dorothee Dormann, Tibor Hortobagyi, Miklos Antal, Antal Nógrádi, Laszlo Nagy
Dátum:2018
Tárgyszavak:idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:The Journal of neuroscience. - 38 : 35 (2018), p. 7683-7700. -
További szerzők:Pájer Krisztián Károlyi Katalin Sieler, Tatiana Jiang, Lu-Lin Kolostyák Zsuzsanna Sári Zsanett (1991-) (klinikai laboratóriumi kutató) Fekecs Zoltán Pap Attila (1980-) (biológus) Patsalos, Andreas Contreras, Gerardo Alvarado (1978-) (orvos) Rehó Bálint (1992-) Papp Zoltán (1965-) (kardiológus, élettanász) Guo, Xiufang Horváth Attila (1988-) (programtervező informatikus) Kiss Gréta Keresztessy Zsolt Vámosi György (1967-) (biofizikus) Hickman, James Xu, Huaxi Dormann, Dorothee Hortobágyi Tibor (1965-) (patológus) Antal Miklós (1951-) (orvos, anatómus) Nógrádi Antal Nagy László (1966-) (molekuláris sejtbiológus, biokémikus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00043
GINOP
116855
OTKA
124298
OTKA
126885
OTKA
TAMOP 422_2012_0023 VÉD-ELEM
TÁMOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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