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001-es BibID:	BIBFORM054206
035-os BibID:	PMID: 24974578
Első szerző:	Brúgós Boglárka (belgyógyász)
Cím:	Use of cyclophosphamide and other immunosuppressive drugs in the treatment of patients with lupus nephritis / B. Brugos, L. Sebestyen, T. Tarr, Z. Vincze
Dátum:	2014
ISSN:	0031-7144
Megjegyzések:	Systemic lupus erythematosus (SLE) is a chronic relapsing systemic autoimmune disease; one of the most serious complications is renal involvement, which is occurring in almost 50% of all patients at the beginning of the disease. The aim of the present study was to compare renal function, proteinuria, activity markers and treatment regimen of active and inactive SLE patients with renal involvement. We analyzed the correlation of serum blood urea nitrogen, creatinine level, glomerular filtration rate, urine total protein/serum creatinine (uTP/creat), CRP to classic activity markers of SLE (serum complement 3, -4 level, anti-dsDNA antibody). Moreover we analyzed the treatment modalities of patients with lupus nephritis (LN). Data of 418 SLE patients were analyzed, out of these patients 128 had biopsy proven lupus nephritis or had more than 3 + proteinuria by urine dipstick analysis (30% of all cases).RESULTS: Data of 128 patients with lupus nephritis were analyzed (mean age 32.18 +/- 11.48 year, time between the diagnosis of SLE and LN was 2.78 +/- 4.59 year). 48% of patients had diffuse proliferative glomerulonephritis, 75% of them received cyclic cyclophosphamide treatment. UTp (total protein)/creatinine level was significantly higher in active LN group (p = 0.03), and correlated to erythrocyte sedimentation rate (p = 0.002, R = 0.52). Mean anti-dsDNA level of patients with active LN was significantly higher (p < 0.001). CONCLUSIONS: Patients with active lupus nephritis are at higher risk of developing renal failure, activity markers and urine protein are elevated in these patients as compared to inactive patients, early aggressive immunosuppressive treatment needs to be started to prevent end-stage renal failure.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Die Pharmzie. - 69 : 6 (2014), p. 442-444. -
További szerzők:	Sebestyén Lilla (1980-) (orvos) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus) Vincze Zoltán (1965-) (orvos)
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001-es BibID:	BIBFORM039815
Első szerző:	Brúgós Boglárka (belgyógyász)
Cím:	Serum and urinary cytokine levels of SLE patients / Brugos B., Vincze Z., Sipka S., Szegedi G., Zeher M.
Dátum:	2012
ISSN:	0031-7144
Megjegyzések:	Systemic lupus erythematosus (SLE) is a chronic, relapsing, polysystemic autoimmune disease with various clinical signs. The prognosis of SLE patients is influenced by neuropsychiatric and renal involvement. Lupus nephritis (LN) is present in 40-60% of patients. Classical laboratory parameters are not sensitive and specific in prediction renal flares, over the last few years there has been a growing interest in searching novel lupus biomarkers predicting future flares. Our goal was to detect serum and urinary level of cytokines in 36 patients with lupus nephritis (34 female and 2 male, mean age: 43.36 +/- 11.53 years), 23 patients with SLE without renal involvement (19 women and 4 men, mean age: 54 +/- 8.71) (both groups followed by the 3rd Department of Internal Medicine, Division of Clinical Immunology, University of Debrecen) and 30 healthy controls (23 female and 7 male, mean age: 45.5 +/- 12.4). Serum IL-1 (interleukin), IL-2 (both p < 0.05), IL-6, IL-13 and IFN-gamma (p < 0.001) levels were significantly higher in lupus nephritis patients, as compared to patients with SLE without renal involvement and healthy controls. Urinary level of IL-1 and TNF-alpha were significantly higher in SLE patients without renal disease (p = 0.012 and p < 0.001), while urinary IFN-gamma was significantly higher in LN patients (p = 0.002). Measurement of IL-6 level in SLE patients could help to predict future renal involvement of SLE patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban cytokin lupus nephritis
Megjelenés:	Pharmazie. - 67 : 5 (2012), p. 411-413. -
További szerzők:	Vincze Zoltán (1965-) (orvos) Sipka Sándor (1945-) (laboratóriumi szakorvos) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
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001-es BibID:	BIBFORM013929
Első szerző:	Vincze Zoltán (orvos)
Cím:	Does impairment of renal and hepatic function influence the metabolism of thrombolytics in patients with myocardial infarction? / Zoltan Vincze, Boglarka Brugos
Dátum:	2008
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Die Pharmazie. - 63 : 3 (2008), p. 245-246. -
További szerzők:	Brúgós Boglárka (1975-) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI elektronikus változat
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