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1.

001-es BibID:BIBFORM103936
035-os BibID:(WoS)000868254300009 (Scopus)85143055930
Első szerző:Aggarwal, Rohit
Cím:Trial of Intravenous Immune Globulin in Dermatomyositis / Aggarwal Rohit, Charles-Schoeman Christina, Schessl Joachim, Bata-Csörgő Zsuzsanna, Dimachkie Mazen M., Griger Zoltan, Moiseev Sergey, Oddis Chester, Schiopu Elena, Vencovsky Jiri, Beckmann Irene, Clodi Elisabeth, Bugrova Olga, Dankó Katalin, Ernste Floranne, Goyal Namita A., Heuer Marvin, Hudson Marie, Hussain Yessar M., Karam Chafic, Magnolo Nina, Nelson Ronald, Pozur Nataliia, Prystupa Liudmyla, Sárdy Miklós, Valenzuela Guillermo, van der Kooi Anneke J., Vu Tuan, Worm Margitta, Levine Todd, ProDERM Trial Group
Dátum:2022
ISSN:0028-4793
Megjegyzések:Background: Intravenous immune globulin (IVIG) for the treatment of dermatomyositis has not been extensively evaluated. Methods: We conducted a randomized, placebo-controlled trial involving patients with active dermatomyositis. The patients were assigned in a 1:1 ratio to receive IVIG at a dose of 2.0 g per kilogram of body weight or placebo every 4 weeks for 16 weeks. The patients who received placebo and those without confirmed clinical deterioration while receiving IVIG could enter an open-label extension phase for another 24 weeks. The primary end point was a response, defined as a Total Improvement Score (TIS) of at least 20 (indicating at least minimal improvement) at week 16 and no confirmed deterioration up to week 16. The TIS is a weighted composite score reflecting the change in a core set of six measures of myositis activity over time; scores range from 0 to 100, with higher scores indicating greater improvement. Key secondary end points included at least moderate improvement (TIS ?40) and major improvement (TIS ?60), and change in score on the Cutaneous Dermatomyositis Disease Area and Severity Index. Results: A total of 95 patients underwent randomization: 47 patients were assigned to the IVIG group, and 48 to the placebo group. At 16 weeks, 79% of the patients in the IVIG group (37 of 47) and 44% of those in the placebo group (21 of 48) had a TIS of at least 20 (difference, 35 percentage points; 95% confidence interval, 17 to 53; P<0.001). The results with respect to the secondary end points, including at least moderate improvement and major improvement, were generally in the same direction as the results of the primary end-point analysis, except for the change in creatine kinase level (an individual core measure of the TIS), which did not differ meaningfully between the two groups. Over 40 weeks, 282 treatment-related adverse events occurred in the IVIG group, including headache (in 42% of patients), pyrexia (in 19%), and nausea (in 16%). A total of 9 serious adverse events that were considered to be related to IVIG occurred, including 6 thromboembolic events. Conclusions: In this 16-week trial involving adults with dermatomyositis, the percentage of patients with a response of at least minimal improvement based on a composite score of disease activity was significantly greater among those who received IVIG than among those who received placebo. IVIG was associated with adverse events, including thromboembolism. (Funded by Octapharma Pharmazeutika; ProDERM ClinicalTrials.gov number, NCT02728752.).
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:New England Journal Of Medicine. - 387 : 14 (2022), p. 1264-1278. -
További szerzők:Charles-Schoeman, Christina Schessl, Joachim Bata-Csörgő Zsuzsanna Dimachkie, Mazen M. Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Moiseev, Sergey Oddis, Chester V. Schiopu, Elena Vencovsky, Jiri Beckmann, Irene Clodi, Elisabeth Bugrova, Olga Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Ernste, Floranne Goyal, Namita A. Heuer, Marvin Hudson, Marie Hussain, Yessar M. Karam, Chafic Magnolo, Nina Nelson, Ronald Pozur, Nataliia Prystupa, Liudmyla Sárdy Miklós Valenzuela, Guillermo van der Kooi, Anneke J. Vu, Tuan Worm, Margitta Levine, Todd ProDERM Trial Group
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2.

001-es BibID:BIBFORM105385
035-os BibID:(cikkazonosító)6814 (WOS)000887393800001 (Scopus)85142444407
Első szerző:Balogh László (sporttudomány)
Cím:The Effect of Aerobic Exercise and Low-Impact Pilates Workout on the Adaptive Immune System / Balogh László, Szabó Krisztina, Pucsok József Márton, Jámbor Ilona, Gyetvai Ágnes, Mile Marianna, Barna Lilla, Szodoray Peter, Tarr Tünde, Csiki Zoltán, Papp Gábor
Dátum:2022
ISSN:2077-0383
Megjegyzések:Growing evidence indicates the pronounced effects of physical activity on immune functions, which may largely depend on the type of exercise, intensity, and duration. However, limited information is available regarding the effects of low-impact exercises, especially on the level of adaptive immune system. Our study aimed to investigate and compare the changes in a broad spectrum of lymphocyte subtypes after 14 weeks of aerobic-type total-body-shaping workouts (TBSW) and Pilates workouts (PW) among healthy individuals. We determined the percentages of peripheral natural killer cells and different T and B lymphocyte subtypes with flow cytometry. At the end of the exercise program, significant changes in naïve and memory lymphocyte ratios were observed in TBSW group. Percentages of naïve cytotoxic T (Tc) cells elevated, frequencies of memory Tc and T-helper cell subsets decreased, and distribution of naïve and memory B cells rearranged. Proportions of activated T cells also showed significant changes. Nonetheless, percentages of anti-inflammatory interleukin (IL)-10-producing regulatory type 1 cells and immunosuppressive CD4+CD127lo/?CD25bright T regulative cells decreased not only after TBSW but also after PW. Although weekly performed aerobic workouts may have a more pronounced impact on the adaptive immune system than low-impact exercises, both still affect immune regulation in healthy individuals.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
aerobic exercise
pilates
adaptive immunity
regulatory T cell
interleukin-10
Megjelenés:Journal of Clinical Medicine. - 11 : 22 (2022), p. 1-13. -
További szerzők:Szabó Krisztina (1987-) (Molekuláris biológus) Pucsok József Márton (1973-) Jámbor Ilona (1985-) (tudományos segédmunkatárs) Gyetvai Ágnes Mile Marianna (1977-) (gyógytornász) Barna Lilla (1991-) Szodoray Péter (1973-) (belgyógyász, orvos) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Papp Gábor (1984-) (belgyógyász)
Pályázati támogatás:TKP2021-EGA-20
Egyéb
ÚNKP 20-5
Egyéb
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3.

001-es BibID:BIBFORM061948
Első szerző:Bodoki Levente (PhD hallgató)
Cím:Inclusion body myositis - a case based clinicopathological update / Bodoki Levente, Nagy-Vincze Melinda, Griger Zoltán, Csonka Tamás, Murnyák Balázs, Kurucz Andrea, Dankó Katalin, Hortobágyi Tibor
Dátum:2014
ISSN:1895-1058 1644-3640
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Central European Journal of Medicine. - 9 : 1 (2014), p. 80-85. -
További szerzők:Nagy-Vincze Melinda (1985-) (orvos) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Csonka Tamás (1984-) (pathológus) Murnyák Balázs (1986-) (molekuláris biológus, genetikus) Kurucz Andrea (1984-) (orvos) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Hortobágyi Tibor (1965-) (patológus)
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4.

001-es BibID:BIBFORM007053
Első szerző:Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases / Bodolay, E., Koch, A. E., Kim, J., Szegedi, G., Szekanecz, Z.
Dátum:2002
ISSN:1582-1838 (Print)
Megjegyzések:Angiogenesis, the formation of new vessels, is important in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. Chemotactic cytokines termed chemokines mediate the ingress of leukocytes, including neutrophils and monocytes into the inflamed synovium. In this review, authors discuss the role of the most important angiogenic factors and angiogenesis inhibitors, as well as relevant chemokines and chemokine receptors involved in chronic inflammatory rheumatic diseases. RA was chosen as a prototype to discuss these issues, as the majority of studies on the role of angiogenesis and chemokines in inflammatory diseases were carried out in arthritis. However, other systemic inflammatory (autoimmune) diseases including systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjogren's syndrome (SS), mixed connective tissue disease (MCTD), polymyositis/dermatomyositis (PM/DM) and systemic vasculites are also discussed in this context. As a number of chemokines may also play a role in neovascularization, this issue is also described here. Apart from discussing the pathogenic role of angiogenesis and chemokines, authors also review the regulation of angiogenesis and chemokine production by other inflammatory mediators, as well as the important relevance of neovascularization and chemokines for antirheumatic intervention.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Angiogenesis Inhibitors
Arthritis, Rheumatoid
Autoimmune Diseases
Chemokines
Growth Substances
Humans
Neovascularization, Pathologic
Receptors, Chemokine
Megjelenés:Journal of Cellular and Molecular Medicine. - 6 : 3 (2002), p. 357-376. -
További szerzők:Koch, Alisa E. Kim, Joon Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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5.

001-es BibID:BIBFORM100364
035-os BibID:(cikkazonosító)5984 (WoS)000737573400001 (Scopus)85121337361
Első szerző:Fedor István (orvos)
Cím:Temporal Relationship of Extraintestinal Manifestations in Inflammatory Bowel Disease / Fedor Istvan, Zold Eva, Barta Zsolt
Dátum:2021
ISSN:2077-0383
Megjegyzések:Thus far, few attempted to characterize the temporal onset of extraintestinal manifestations (EIM) in inflammatory bowel diseases (IBD). We sought to determine the time of onset of these findings in a patient cohort with IBD. Methods: We reviewed the electronic health records of 508 IBD patients (303 CD, 205 UC) and summarized general patient characteristics and the temporal relationship and order of presentation of extraintestinal manifestations. Results: CD patients were younger at diagnosis. CD patients with ileocolonic involvement (L3) were younger, and UC patients with pancolitis (E3) were slightly younger at diagnosis. A total of 127 out of 303 (41.91%) CD and 81 out of 205 (39.51%) UC patients had EIMs (p = 0.5898). Some patients presented with EIMs before the diagnosis of IBD (9.45% of Crohn's disease and 17.28% of ulcerative colitis patients with EIMs, respectively). Of these, seven cases (four in CD and three in UC) were visible by inspection of the patients (either dermatologic or ocular findings). The diagnosis of IBD and extraintestinal symptoms often occurred within a year (22.83% of CD and 16.04% of UC patients). Typically, the diagnosis of the first extraintestinal symptoms happened after the onset of bowel disease (+4.3 (?6.3) years, range: 10 years before to 30 years after in Crohn's disease and +3.8 (?10) years, range: 24 years before to 30 years after) in ulcerative colitis. UC patients with pancolitis (E3) usually had EIMs earlier in the disease course and displayed EIMs more frequently before IBD diagnosis. Furthermore, patients with pancolitis developed EIMs more frequently than other sub-groups. Conclusion: Extraintestinal manifestations in inflammatory bowel diseases can present at any time, relative to the bowel symptoms. In cases, the presence of a characteristic EIM might be a harbinger of the development of IBD.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
inflammatory bowel disease
Crohn's disease
ulcerative colitis
extraintestinal manifestations
Megjelenés:Journal of Clinical Medicine. - 10 : 24 (2021), p. 1-13. -
További szerzők:Zöld Éva (1978-) (belgyógyász) Barta Zsolt (1964-) (belgyógyász, gasztroenterológus)
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6.

001-es BibID:BIBFORM095950
Első szerző:Fedor István (orvos)
Cím:Microscopic colitis : controversies in clinical symptoms and autoimmune comorbidities / Istvan Fedor, Eva Zold, Zsolt Barta
Dátum:2021
ISSN:0785-3890 1365-2060
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Annals of Medicine. - 53 : 1 (2021), p. 1279-1284. -
További szerzők:Zöld Éva (1978-) (belgyógyász) Barta Zsolt (1964-) (belgyógyász, gasztroenterológus)
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7.

001-es BibID:BIBFORM077919
Első szerző:Fedor István (orvos)
Cím:Food-specific IgG Antibodies in Crohn's Disease : what Came First, the Chicken or the Egg? / Istvan Fedor, Éva Zold, Zsolt Barta
Dátum:2019
ISSN:0918-2918
Tárgyszavak:Orvostudományok Klinikai orvostudományok szerkesztői levél
inflammatory bowel disease
Crohn's disease
food allergy
6-food elimination diet
EoE
Megjelenés:Internal Medicine. - 58 : 19 (2019), p. 2123. -
További szerzők:Zöld Éva (1978-) (belgyógyász) Barta Zsolt (1964-) (belgyógyász, gasztroenterológus)
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8.

001-es BibID:BIBFORM001047
Első szerző:Griger Zoltán (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Cím:Protein kinase C-beta and -delta isoenzymes promote arachidonic acid production and proliferation of MonoMac-6 cells / Griger Z., Páyer E., Kovács I., Tóth I. B., Kovács L., Sipka S., Bíró T.
Dátum:2007
ISSN:0946-2716 (Print)
Megjegyzések:In this study, we investigated the putative roles of certain protein kinase C (PKC) isoenzymes in the regulation of proliferation and arachidonic acid (AA) release in the human monocytoid MonoMac-6 cell line. Experiments employing specific PKC inhibitors and molecular biological methods (RNA-interference, recombinant overexpression) revealed that the two dominantly expressed isozymes, i.e., the "conventional" cPKCbeta and the "novel" nPKCdelta, promote AA production and cellular proliferation. In addition, using different phospholipase A(2) (PLA(2)) inhibitors, we were able to show that the calcium-independent iPLA(2) as well as diacylglycerol lipase (but not the cytosolic PLA(2)) function as "downstream" targets of cPKCbeta and nPKCdelta. In addition, we have also found that, among the other existing PKC isoforms, cPKCalpha plays a minor inhibitory role, whereas nPKCvarepsilon and aPKCzeta apparently do not regulate these cellular processes. In conclusion, in this paper we provide the first evidence that certain PKC isoforms play pivotal, specific, and (at least partly) antagonistic roles in the regulation of AA production and cellular proliferation of human monocytoid MonoMac-6 cells.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Molecular Medicine 85 : 9 (2007), p. 1031-1042. -
További szerzők:Páyer Edit (1982-) Kovács Ildikó Tóth István Balázs (1978-) (élettanász) Kovács László (1939-) (élettanász) Sipka Sándor (1945-) (laboratóriumi szakorvos) Bíró Tamás (1968-) (élettanász)
Internet cím:elektronikus változat
elektronikus változat
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9.

001-es BibID:BIBFORM102081
035-os BibID:(cikkazonosító)3006 (WoS)000809980800001 (Scopus)85130822695
Első szerző:Kövér Ágnes (szociológus)
Cím:A Comprehensive Investigation into the Distribution of Circulating B Cell Subsets in the Third Trimester of Pregnancy / Ágnes Kövér, Rudolf Lampé, Krisztina Szabó, Tünde Tarr, Gábor Papp
Dátum:2022
ISSN:2077-0383
Megjegyzések:Maternal B cells play a crucial role in the development and maintenance of pregnancy, due to their humoral activities and regulatory functions. In the study, we investigated the alterations in the distributions of naïve and memory B cell subsets, as well as regulatory B (Breg) cells, in the third trimester of pregnancy. Peripheral blood from 14 healthy pregnant women in the third trimester and 7 healthy non-pregnant women was collected and examined for the frequencies of B cell subsets, including IgD+CD27? naïve, IgD+CD27+ un-switched memory, IgD?CD27+ switched memory, CD38intCD24int mature?naïve, CD38?CD24hi primarily memory and CD38hiCD24hi transitional B cells by flow cytometry. Breg cell subsets were also characterized based on the expression of CD5, CD1d and IL-10. In pregnant women, the proportions of un-switched memory and transitional B cells were significantly decreased. Additionally, the frequencies of both CD5+CD1d+ Breg and IL-10-producing B10 cells were decreased in pregnancy. Changes in the distribution of transitional B cells as well as Breg cells may be crucial contributors for the development of altered maternal immune responses and tolerance needed for the maintenance of normal pregnancy in the third trimester.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Clinical Medicine. - 11 : 11 (2022), p. 1-11. -
További szerzők:Lampé Rudolf (1983-) (szülész-nőgyógyász) Szabó Krisztina (1987-) (Molekuláris biológus) Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus) Papp Gábor (1984-) (belgyógyász)
Pályázati támogatás:K 124177
Egyéb
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10.

001-es BibID:BIBFORM047187
035-os BibID:PMID:22732951
Első szerző:Labirua-Iturburu, Ane
Cím:Anti-PL-7 (anti-threonyl-tRNA synthetase) antisynthetase syndrome : clinical manifestations in a series of patients from a European multicenter study (EUMYONET) and review of the literature / Ane Labirua-Iturburu, Albert Selva-O'Callaghan, Melinda Vincze, Katalin Dankó, Jiri Vencovsky, Benjamin Fisher, Peter Charles, Maryam Dastmalchi, Ingrid E. Lundberg
Dátum:2012
ISSN:0025-7974
Megjegyzések:Autoantibodies against several aminoacyl-transfer-RNA synthetases have been described in patients with myositis; anti-threonyl-tRNA synthetase (anti-PL-7) is one of the rarest. We describe the clinical and laboratory characteristics of a cohort of European anti-PL-7 patients, and compare them with previously reported cases. This multicenter study of patients positive for anti-PL-7, identified between 1984 and 2011, derives from the EUMYONET cohort. Clinical and serologic data were obtained by retrospective laboratory and medical record review, and statistical analyses were performed with chi-squared and Fisher exact tests. Eighteen patients, 15 women, were anti-PL-7 antibody positive. Median follow-up was 5.25 years (interquartile range, 2.8-10.7 yr), and 4 patients died. All patients had myositis (12 polymyositis, 5 dermatomyositis, and 1 amyopathic dermatomyositis), 10 (55.6%) had interstitial lung disease, and 9 (50%) had pericardial effusion. Occupational exposure to organic/inorganic particles was more frequent in patients with interstitial lung disease than in the remaining patients (5 of 10 vs. 1 of 7; p = 0.152), although the difference was not significant. Concurrent autoantibodies against Ro60 and Ro52 were seen in 8 of 14 (57%) patients studied. In the literature review the most common manifestations of anti-PL-7 antisynthetase syndrome were interstitial lung disease (77%), myositis (75%), and arthritis (56%). As in other subsets of the antisynthetase syndrome, myositis and interstitial lung disease are common features of the anti-PL-7 antisynthetase syndrome. In addition, we can add pericarditis as a possible manifestation related to anti-PL-7 antibodies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medicine 91 : 4 (2012), p. 206-211. -
További szerzők:Selva-O'Callaghan, Albert Nagy-Vincze Melinda (1985-) (orvos) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Vencovsky, Jiri Fisher, Benjamin Charles, Peter Dastmalchi, Maryam Lundberg, Ingrid
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11.

001-es BibID:BIBFORM061954
Első szerző:Murnyák Balázs (molekuláris biológus, genetikus)
Cím:Inclusion body myositis : pathomechanism and lessons from genetics / Balázs Murnyák, Levente Bodoki, Melinda Vincze, Zoltán Griger, Tamás Csonka, Rita Szepesi, Andrea Kurucz, Katalin Dankó, Tibor Hortobágyi
Dátum:2015
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Open Medicine 10 (2015), p. 188-193. -
További szerzők:Bodoki Levente (1986-) (PhD hallgató) Nagy-Vincze Melinda (1985-) (orvos) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Csonka Tamás (1984-) (pathológus) Szepesi Rita (1975-) (neurológus) Kurucz Andrea (1984-) (orvos) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Hortobágyi Tibor (1965-) (patológus)
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12.

001-es BibID:BIBFORM111641
035-os BibID:(scopus)85160027968 (cikkazonosító)1168359
Első szerző:Vincze Anett
Cím:Pruritogenic molecules in the skin of patients with dermatomyositis / Vincze Anett, Herczeg-Lisztes Erika, Szabó Katalin, Béldi Tibor Gábor, Nagy-Vincze Melinda, Pór Ágnes, Varga József, Dankó Katalin, Biró Tamás, Tóth Balázs István, Griger Zoltán
Dátum:2023
ISSN:2296-858X
Megjegyzések:Introduction: Pruritus is a common excruciating symptom in systemic autoimmune diseases such as dermatomyositis (DM) but the pathogenesis is not fully understood. We intended to investigate the targeted expression analysis of candidate molecules involved in the development of pruritus in lesional vs. non-lesional skin samples of patients affected with active DM. We looked for correlations between the investigated pruriceptive signaling molecules, disease activity, and itching sensation of DM patients. Methods: Interleukins (IL-33 and IL-6), tumor necrosis factor ? (TNF-?), peroxisome proliferator-activated receptor ? (PPAR-?), and ion channels belonging to the transient receptor potential (TRP) family were analyzed. The expression of TNF-?, PPAR-?, IL-33, IL-6, and TRP channels in lesional DM skin was evaluated by RT-qPCR and immunohistochemistry and was compared with non-lesional DM skin samples. Pruritus, disease activity, and damage of DM were evaluated by the 5-D itch scale and Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI), respectively. Statistical analysis was performed with IBM SPSS 28 software. Results: A total of 17 active DM patients participated in the study. We could show that the itching score was positively correlated with the CDASI activity score (Kendall's tau-b = 0.571; p = 0.003). TNF-? gene expression was significantly higher in lesional DM skin than in non-lesional DM skin (p = 0.009) and differed in the subgroups of patients with different itch intensities (p = 0.038). The mRNA expression of lesional IL-6 correlated positively with 5-D itch and CDASI activity score (Kendall's tau-b = 0.585; p = 0.008 and 0.45; p = 0.013, respectively). TRPV4 expressions were positively correlated with CDASI damage score (Kendall's tau-b = 0.626; p < 0.001), but the mRNA expressions of the TRP family, PPAR-?, IL-6, and IL-33 were not different in lesional and non-lesional samples. Immunohistochemistry analysis did not find significant alterations in the expressions of TNF-?, PPAR-?, IL-6, and IL-33 in lesional and non-lesional regions. Discussion: Our results argue that cutaneous disease activity, TNF-?, and IL-6 might play a central role in DM-associated itch, while TRPV4 plays a central role in tissue regeneration.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
dermatomyositis
inflammatory myopathies
itch
pruritus
TRP channels
TNF-α
IL-6
Megjelenés:Frontiers in Medicine. - 10 (2023), p. 1168359. -
További szerzők:Lisztes Erika (1986-) (élettanász) Szabó Katalin (1991-) (orvos) Béldi Tibor (1994-) (orvos) Nagy-Vincze Melinda (1985-) (orvos) Pór Ágnes Varga József (1955-) (fizikus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Bíró Tamás (1968-) (élettanász) Tóth István Balázs (1978-) (élettanász) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
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120187
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EFOP-3.6.3-VEKOP-16-2017-00009
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Bolyai János Kutatási Ösztöndíj
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