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1.

001-es BibID:BIBFORM076382
Első szerző:Balogh Emese (reumatológus)
Cím:Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis / Emese Balogh, Anita Pusztai, Attila Hamar, Edit Végh, Szilvia Szamosi, György Kerekes, Jennifer McCormick, Monika Biniecka, Sándor Szántó, Gabriella Szűcs, Zoltán Nagy, Ursula Fearon, Douglas J. Veale, Zoltán Szekanecz
Dátum:2019
ISSN:1521-6616
Megjegyzések:Several inflammatory, proteolytic, angiogenic and bone-associated factors play a role in the development of autoimmune, accelerated atherosclerosis in rheumatic diseases. Some of these may serve as biomarkers of vascular pathology and may be useful in the follow-up of vascular damage and outcome. Multi-biomarker profiles rather than a single markers would likely be optimal in this respect.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Autoimmune atherosclerosis
Cardiovascular disease
Autoimmunity
Angiogenesis
Biomarkers
Megjelenés:Clinical Immunology. - 199 (2019), p. 47-51. -
További szerzők:Karancsiné Pusztai Anita (1989-) (tudományos segédmunkatárs) Hamar Attila Béla (1990-) (általános orvos) Végh Edit (1978-) (reumatológus, belgyógyász) Szamosi Szilvia (1975-) (belgyógyász, reumatológus) Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) McCormick, Jennifer Biniecka, Monika Szántó Sándor (1968-) (belgyógyász, reumatológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nagy Zoltán (orvos) Fearon, Ursula Veale, Douglas J. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Pályázati támogatás:TÁMOP-4.2.4.A/2-11/1-2012-0001
TÁMOP
GINOP-2.3.2-15-2016-00015
GINOP
GINOP-2.3.2-15-2016-00050
GINOP
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2.

001-es BibID:BIBFORM044036
Első szerző:Besenyei Tímea (reumatológus, belgyógyász)
Cím:Non-MHC Risk Alleles in Rheumatoid Arthritis and in the Syntenic Chromosome Regions of Corresponding Animal Models / Besenyei Timea, Kadar Andras, Tryniszewska Beata, Kurko Julia, Rauch Tibor A., Glant Tibor T., Mikecz Katalin, Szekanecz Zoltan
Dátum:2012
ISSN:1740-2522
Megjegyzések:Rheumatoid arthritis (RA) is a polygenic autoimmune disease primarily affecting the synovial joints. Numerous animal models show similarities to RA in humans; some of them not only mimic the clinical phenotypes but also demonstrate the involvement of homologous genomic regions in RA. This paper compares corresponding non-MHC genomic regions identified in rodent and human genome-wide association studies (GWAS). To date, over 30 non-MHC RA-associated loci have been identified in humans, and over 100 arthritis-associated loci have been identified in rodent models of RA. The genomic regions associated with the disease are designated by the name(s) of the gene having the most frequent and consistent RA-associated SNPs or a function suggesting their involvement in inflammatory or autoimmune processes. Animal studies on rats and mice preferentially have used single sequence length polymorphism (SSLP) markers to identify disease-associated qualitative and quantitative trait loci (QTLs) in the genome of F2 hybrids of arthritis-susceptible and arthritis-resistant rodent strains. Mouse GWAS appear to be far ahead of rat studies, and significantly more mouse QTLs correspond to human RA risk alleles
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Rheumatoid arthritis
polygenic autoimmune disease
Megjelenés:Clinical And Development Immunology. - 2012 (2012), p. 1-14. -
További szerzők:Kádár András (1977-) (belgyógyász) Tryniszewska Beáta Kurkó Júlia Emese (1979-) (reumatológus) Rauch Tibor A. Glant Tibor T. Mikecz Katalin Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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DOI
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3.

001-es BibID:BIBFORM015807
Első szerző:Centola, Michael
Cím:Gene expression profiles of systemic lupus erythematosus and rheumatoid arthritis / Centola, M., Szekanecz, Z., Kiss, E., Zeher, M., Szegedi, G., Nakken, B., Szodoray, P.
Dátum:2007
ISSN:1744-666X
Megjegyzések:Gene expression profiling using microarray technology is being employed to define specific molecular mediators and pathways involved in immunobiology, to understand the intricate interplay of genes participating in the pathogenesis, and to develop biomarkers of disease activity in both systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). This review summarizes the latest information on the pathogenesis of SLE and RA and describes the utilization of microarray technology in these systemic autoimmune diseases.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
gene expression profile
microarray
rheumatoid arthritis
systemic lupus erythematosus
Megjelenés:Expert Review of Clinical Immunology. - 3 : 5 (2007), p. 797-806. -
További szerzők:Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Kiss Emese (1960-) (belgyógyász, immunológus) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Nakken, Britt Szodoray Péter (1973-) (belgyógyász, orvos)
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4.

001-es BibID:BIBFORM044038
Első szerző:Kurkó Júlia Emese (reumatológus)
Cím:Genetics of Rheumatoid Arthritis : a Comprehensive Review / Kurkó Júlia, Besenyei Timea, Laki Judit, Glant Tibor T., Mikecz Katalin, Szekanecz Zoltán
Dátum:2013
ISSN:1080-0549
Megjegyzések:The "Bermuda triangle" of genetics, environment and autoimmunity is involved in the pathogenesis of rheumatoid arthritis (RA). Various aspects of genetic contribution to the etiology, pathogenesis and outcome of RA are discussed in this review. The heritability of RA has been estimated to be about 60 %, while the contribution of HLA to heritability has been estimated to be 11-37 %. Apart from known shared epitope (SE) alleles, such as HLA-DRB1*01 and DRB1*04, other HLA alleles, such as HLA-DRB1*13 and DRB1*15 have been linked to RA susceptibility. A novel SE classification divides SE alleles into S1, S2, S3P and S3D groups, where primarily S2 and S3P groups have been associated with predisposition to seropositive RA. The most relevant non-HLA gene single nucleotide polymorphisms (SNPs) associated with RA include PTPN22, IL23R, TRAF1, CTLA4, IRF5, STAT4, CCR6, PADI4. Large genome-wide association studies (GWAS) have identified more than 30 loci involved in RA pathogenesis. HLA and some non-HLA genes may differentiate between anti-citrullinated protein antibody (ACPA) seropositive and seronegative RA. Genetic susceptibility has also been associated with environmental factors, primarily smoking. Some GWAS studies carried out in rodent models of arthritis have confirmed the role of human genes. For example, in the collagen-induced (CIA) and proteoglycan-induced arthritis (PgIA) models, two important loci - Pgia26/Cia5 and Pgia2/Cia2/Cia3, corresponding the human PTPN22/CD2 and TRAF1/C5 loci, respectively - have been identified. Finally, pharmacogenomics identified SNPs or multiple genetic signatures that may be associated with responses to traditional disease-modifying drugs and biologics
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Rheumatoid arthritis
Murine arthritis
Genetics
Single nucleotide polymorphisms
HLA-DR
GWAS
Megjelenés:Clinical Reviews In Allergy & Immunology 45 : 2 (2013), p. 170-179. -
További szerzők:Besenyei Tímea (1980-) (reumatológus, belgyógyász) Laki Judit Glant Tibor T. Mikecz Katalin Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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DOI
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5.

001-es BibID:BIBFORM035128
035-os BibID:(cikkazonosító)957151
Első szerző:Nakken, Britt
Cím:Immune-regulatory mechanisms in systemic autoimmune and rheumatic diseases / Britt Nakken, Philip Alex, Ludvig Munthe, Zoltan Szekanecz, Peter Szodoray
Dátum:2012
Megjegyzések:Systemic autoimmune and rheumatic diseases (SAIRDs) are thought to develop due to the failure of autoimmune regulation and tolerance. Current therapies, such as biologics, have improved the clinical results of SAIRDs; however, they are not curative treatments. Recently, new discoveries have been made in immune tolerance and inflammation, such as tolerogenic dendritic cells, regulatory T and B cells, Th 17 cells, inflammatory and tolerogenic cytokines, and intracellular signaling pathways. They lay the foundation for the next generation of the therapies beyond the currently used biologic therapies. New drugs should target the core processes involved in disease mechanisms with the aim to attain complete cure combined with safety and low costs compared to the biologic agents. Re-establishment of autoimmune regulation and tolerance in SAIRDs by the end of the current decade should be the final and realistic target.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical and Developmental Immunology. - 2012 (2012), p. 1-2. -
További szerzők:Philip, Alex Munthe, Ludvig A. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szodoray Péter (1973-) (belgyógyász, orvos)
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6.

001-es BibID:BIBFORM015838
Első szerző:Orbach, Hedi
Cím:Prolactin and Autoimmunity : hyperprolactinemia Correlates with Serositis and Anemia in SLE Patients / Orbach, H., Zandman-Goddard, G., Boaz, M., Agmon-Levin, N., Amital, H., Szekanecz, Z., Szucs, G., Rovensky, J., Kiss, E., Doria, A., Ghirardello, A., Gomez-Arbesu, J., Stojanovich, L., Ingegnoli, F., Meroni, P. L., Rozman, B., Blank, M., Shoenfeld, Y.
Dátum:2012
ISSN:1559-0267 (Electronic)
Megjegyzések:Evidence points to an association of prolactin to autoimmune diseases. We examined the correlation between hyperprolactinemia and disease manifestations and activity in a large patient cohort. Age- and sex-adjusted prolactin concentration was assessed in 256 serum samples from lupus patients utilizing the LIASON prolactin automated immunoassay method (DiaSorin S.p.A, Saluggia, Italy). Disease activity was defined as present if European Consensus Lupus Activity Measurement (ECLAM) > 2 or Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) > 4. Lupus manifestations were grouped by organ involvement, laboratory data, and prescribed medications. Hyperprolactinemia was presented in 46/256 (18%) of the cohort. Hyperprolactinemic patients had significantly more serositis (40% vs. 32.4%, p = 0.03) specifically, pleuritis (33% vs. 17%, p = 0.02), pericarditis (30% vs. 12%, p = 0.002), and peritonitis (15% vs. 0.8%, p = 0.003). Hyperprolactinemic subjects exhibited significantly more anemia (42% vs. 26%, p = 0.02) and marginally more proteinuria (65.5% vs. 46%, p = 0.06). Elevated levels of prolactin were not significantly associated with other clinical manifestations, serology, or therapy. Disease activity scores were not associated with hyperprolactinemia. Hyperprolactinemia in lupus patients is associated with all types of serositis and anemia but not with other clinical, serological therapeutic measures or with disease activity. These results suggest that dopamine agonists may be an optional therapy for lupus patients with hyperprolactinemia.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical Reviews in Allergy and Immunology. - 42 : 2 (2012), p. 189-198. -
További szerzők:Zandman-Goddard, Gisele Boaz, Mona Agmon-Levin, Nancy Amital, Howard Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Rovensky, Josef Kiss Emese (1960-) (belgyógyász, immunológus) Doria, Andrea Ghirardello, A. Gomez-Arbesu, Jesus Stojanovich, Ljudmila Ingegnoli, Francesca Meroni, Pier Luigi Rozman, Blaz Blank, Marion Shoenfeld, Yehuda
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7.

001-es BibID:BIBFORM007089
Első szerző:Szamosi Szilvia (belgyógyász, reumatológus)
Cím:Plasma homocysteine levels, the prevalence of methylenetetrahydrofolate reductase gene C677T polymorphism and macrovascular disorders in systemic sclerosis : risk factors for accelerated macrovascular damage? / Szamosi, S., Csiki, Z., Szomjak, E., Szolnoki, E., Szoke, G., Szekanecz, Z., Szegedi, G., Shoenfeld, Y., Szucs, G.
Dátum:2009
ISSN:1080-0549 (Print)
Megjegyzések:The purpose of this study was to investigate plasma homocysteine (Hcy) levels in patients with systemic sclerosis (SSc) and to study the association between plasma Hcy, C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR), and the clinical manifestations in SSc. Associations of Hcy level, C677T MTHFR polymorphism, and macrovascular diseases were investigated in 152 patients with SSc and 58 controls. No significant differences in Hcy levels and MTHFR genotypes were found in SSc patients compared to controls or in SSc patients with limited cutaneous compared to diffuse disease. Significantly higher Hcy concentration was observed in patients with macroangiopathy/thromboembolic events compared to patients without such clinical manifestations (p < 0.05). There was significant correlation between age and macrovascular disorders, between Hcy level and the disease duration (r = 0.164; p < 0.05). Seventy-one percent of patients with macrovascular disorders had MTHFR polymorphism. In addition, 45% of patients with hyperhomocysteinemia had pulmonary hypertension. The presence of MTHFR C677T mutation influences the incidence of macrovascular abnormalities in SSc patients. Elevated Hcy levels may be associated with disease duration and the evolution of macrovascular disorders and pulmonary hypertension in SSc.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Female
egyetemen (Magyarországon) készült közlemény
Genetic Predisposition to Disease
Homocysteine
Humans
Hypertrophy, Right Ventricular
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Polymorphism, Single Nucleotide
Pulmonary Fibrosis
Risk Factors
Scleroderma, Systemic
Thromboembolism
Time Factors
Megjelenés:Clinical Reviews in Allergy and Immunology. - 36 : 2-3 (2009), p. 145-9. -
További szerzők:Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Szomják Edit (1961-) (belgyógyász) Szolnoki Erzsébet Szőke Gabriella Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Shoenfeld, Yehuda Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
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DOI
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8.

001-es BibID:BIBFORM007130
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Anti-citrullinated protein antibodies in rheumatoid arthritis : as good as it gets? / Szekanecz, Z., Soos, L., Szabo, Z., Fekete, A., Kapitany, A., Vegvari, A., Sipka, S., Szucs, G., Szanto, S., Lakos, G.
Dátum:2008
ISSN:1080-0549 (Print)
Megjegyzések:Anti-citrullinated protein antibodies (ACPAs) have recently emerged as sensitive and specific serological markers of rheumatoid arthritis (RA), providing superior alternative of the rheumatoid factor (RF) test in the laboratory diagnostics of RA. The first members of this autoantibody family were anti-perinuclear factor (APF) and anti-keratin antibodies (AKA). It became evident that both APF and AKA recognize citrullinated epitopes of filaggrin. Citrullination is a post-translational modification of arginine by deimination, physiologically occurring during apoptosis, inflammation or keratinization. The presence of several citrullinated proteins has been demonstrated in the RA synovium. The identification of citrullinated epitopes as targets for anti-filaggrin antibodies led to the development of the first and later second generation anti-cyclic citrullinated peptide (anti-CCP) antibody assays. The widely used anti-CCP2 assays have high diagnostic sensitivity and specificity, and they also show important predictive and prognostic value in RA. The anti-Sa antibody has been identified a decade ago; however, recent studies confirmed that anti-Sa is directed against citrullinated vimentin, hence it is a new member of the family of ACPAs. The newly developed anti-mutated citrullinated vimentin (anti-MCV) assay has similar diagnostic performance than the anti-CCP2 ELISA; however, the diagnostic spectrum of the anti-MCV test is somewhat different from that of anti-CCP2. It's especially useful in the diagnosis of RA in RF and anti-CCP2 seronegative patients. The combined application of anti-CCP2 and anti-MCV assays can improve the laboratory diagnostics of RA. The family of ACPAs is expected to expand; there is an increasing need for developing new diagnostic strategies after careful evaluation of the characteristics of the available assays.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Arthritis, Rheumatoid/*diagnosis/immunology
Autoantibodies/*blood
Humans
Peptides, Cyclic/*immunology
Vimentin/*immunology
Megjelenés:Clinical Reviews in Allergy and Immunology. - 34 : 1 (2008), p. 26-31. -
További szerzők:Soós Lilla Szabó Zoltán (1970-) (belgyógyász, reumatológus) Fekete Andrea (immunológus) Kapitány Anikó (1979-) (molekuláris biológus) Végvári Anikó (belgyógyász, III. sz. Belgyógyászati Klinika) Sipka Sándor (1945-) (laboratóriumi szakorvos) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szántó Sándor (1968-) (belgyógyász, reumatológus) Lakos Gabriella (1963-) (laboratóriumi szakorvos, transzfúziológus, immunológus)
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9.

001-es BibID:BIBFORM015927
Első szerző:Zandman-Goddard, Gisele
Cím:Hyperferritinemia is Associated with Serologic Antiphospholipid Syndrome in SLE Patients / Zandman-Goddard, G., Orbach, H., Agmon-Levin, N., Boaz, M., Amital, H., Szekanecz, Z., Szucs, G., Rovensky, J., Kiss, E., Corocher, N., Doria, A., Stojanovich, L., Ingegnoli, F., Meroni, P. L., Rozman, B., Gomez-Arbesu, J., Blank, M., Shoenfeld, Y.
Dátum:2013
ISSN:1559-0267 (Electronic)
Megjegyzések:Ferritin may play a direct role on the immune system. We sought to determine if elevated levels of ferritin in lupus patients correlate with disease activity and organ involvement in a large cohort. Ferritin levels (gender and age adjusted) were assessed in 274 lupus serum samples utilizing the LIASON Ferritin automated immunoassay method. Significant disease activity was determined if European Consensus Lupus Activity Index (ECLAM) > 2 or Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) > 4. Utilizing an EXCEL database, we compared elevated ferritin levels to manifestations grouped by organ involvement, serology, and previous therapy. The patients were predominantly female (89%), median age was 37 years old, and disease duration was 10.6 +/- 7.7 years. Hyperferritinemia was found in 18.6% of SLE patients. Compared to subjects with normal ferritin levels, a significantly greater proportion of patients with hyperferritinemia had thrombocytopenia (15.4% vs. 33.3%, p = 0.003) and lupus anticoagulant (11.3% vs. 29.0%, p = 0.01). Additionally, compared to normoferritinemic subjects, hyperferritinemic subjects had significantly higher total aCL (99.7 +/- 369 vs. 30.9 +/- 17.3 GPI, p = 0.02) and aCL IgM antibody levels (75.3 +/- 357.4 vs. 9.3 +/- 10.3 GPI, p = 0.02), and marginally lower aCL IgG antibody levels (9.2 +/- 4.9 vs. 9.7 +/- 3.9 GPI, p = 0.096). While the ECLAM score significantly correlated with hyperferritinemia (p = 0.04), the SLEDAI score was marginally associated with hyperferritinemia (p = 0.1). Serositis was marginally associated with hyperferritinemia, but not with other manifestations. An association with serologic APS was encountered. Hyperferritinemia was associated with thrombocytopenia, lupus anticoagulant, and anti-cardiolipin antibodies suggest that it may be an early marker for secondary antiphospholipid syndrome in SLE patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical Reviews in Allergy and Immunology. - 44 : 1 (2013), p. 23-30. -
További szerzők:Orbach, Hedi Agmon-Levin, Nancy Boaz, Mona Amital, Howard Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Rovensky, Josef Kiss Emese (1960-) (belgyógyász, immunológus) Corocher, Nadia Doria, Andrea Stojanovich, Ljudmila Ingegnoli, Francesca Meroni, Pier Luigi Rozman, Blaz Gomez-Arbesu, Jesus Blank, Miri Shoenfeld, Yehuda
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