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1.

001-es BibID:BIBFORM093358
035-os BibID:(WoS)000638059000001 (Scopus)85104071207
Első szerző:Atzeni, Fabiola
Cím:Cardiovascular effects of approved drugs for rheumatoid arthritis / Fabiola Atzeni, Javier Rodríguez-Carrio, Cǎlin D. Popa, Michael T. Nurmohamed, Gabriella Szűcs, Zoltán Szekanecz
Dátum:2021
ISSN:1759-4790 1759-4804
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Nature Reviews Rheumatology. - 17 : 5 (2021), p. 270-290. -
További szerzők:Rodríguez-Carrio, Javier Popa, Cǎlin D. Nurmohamed, Michael T. Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM015795
Első szerző:Avouac, Jérôme
Cím:Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis : results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database / Avouac, J., Walker, U., Tyndall, A., Kahan, A., Matucci-Cerinic, M., Allanore, Y., EUSTAR
Dátum:2010
ISSN:0315-162X (Print)
Megjegyzések:To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). METHODS: This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. RESULTS: We recruited 7286 patients with SSc; their mean age was 56 +/- 14 years, disease duration 10 +/- 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. CONCLUSION: Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with a more severe disease and with systemic inflammation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adult
Aged
Clinical Trials as Topic
Cross-Sectional Studies
Databases, Factual
Female
Humans
Inflammation
Joint Diseases
Joints/pathology
Male
Middle Aged
Range of Motion, Articular
Scleroderma, Localized
Scleroderma, Systemic
Synovitis
Tendons
Megjelenés:The Journal of Rheumatology. - 37 : 7 (2010), p. 1488-1501. -
További szerzők:Walker, Ulrich Tyndall, Alan Kahan, André Matucci-Cerinic, Marco Allanore, Yannick Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) EUSTAR
Internet cím:DOI
elektronikus változat
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3.

001-es BibID:BIBFORM033051
035-os BibID:PMID:21505766 WOS:000293238300015
Első szerző:Baksay Beáta
Cím:Coexistence of ankylosing spondylitis and rheumatoid arthritis in a female patient / Beáta Baksay, Alíz Dér, Zoltán Szekanecz, Sándor Szántó, Attila Kovács
Dátum:2011
ISSN:0770-3198
Megjegyzések:Ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are two distinguished representatives of inflammatory rheumatic diseases. The two diseases differ significantly in their etiology, pathology, clinical signs, and in the nature of articular manifestations. Their association has been a rarity in the literature. Here, authors describe a case of a 55-year-old female patient with AS associated with RA. Her spinal symptoms started in 1979, and the diagnosis of AS was established based on the typical clinical picture and X-ray. She developed severe spinal deformity during the next decades. In 2005, peripheral polyarthritis developed, although neither the diagnosis nor the treatment was modified. In 2007, authors diagnosed seropositive RA. Therapy included anti-inflammatory therapy and traditional disease-modifying agents, eventually followed by biological therapy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
egyetemen (Magyarországon) készült közlemény
Megjelenés:Clinical Rheumatology. - 30 : 8 (2011), p. 1119-1122. -
További szerzők:Dér Alíz Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szántó Sándor (1968-) (belgyógyász, reumatológus) Kovács Attila (reumatológus)
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DOI
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4.

001-es BibID:BIBFORM081589
Első szerző:Balogh Emese (reumatológus)
Cím:Effects of one-year anti-TNF-[alfa] therapy on biomarkers of angiogenesis and functional vascular parameters in arthritides / Emese Balogh, Edit Végh, György Kerekes, Anita Pusztai, Attila Hamar, Katalin Hodosi, Szilvia Szamosi, Andrea Váncsa, Péter Csomor, Levente Bodoki, Lilla Pogácsás, Fruzsina Balázs, Ildikó Tar, Jennifer McCormick, Monika Biniecka, Ursula Fearon, Karin Lundberg, Nastya Kharlamova, Sándor Szántó, Gabriella Szűcs, Zoltán Nagy, Douglas J. Veale, Zoltán Szekanecz
Dátum:2019
Megjegyzések:Background: Increased cardiovascular (CV) morbidity and mortality and abundant angiogenesis have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Biologics may influence both vascular function and angiogenesis. Here, vascular function, markers of atherosclerosis angiogenesis and the effects of anti-TNF therapy on these biomarkers were assessed arthritides. Patients and methods: Altogether 53 arthritis patients including 36 RA patients treated with etanercept (ETN) or certolizumab pegol (CZP) and 17 AS patients treated with ETN were included in a 12-month follow-up study. Angiogenesis markers including vascular endothelial (VEGF) and platelet-derived growth factor (PDGF-BB), angiopoetin 1 and 2 (Ang1, Ang2) and thrombospondin 1 (TSP-1) were assessed by ELISA. Anti-CCP and anti-citrullinated enolase peptide (CEP) antibodies were also determined by ELISA. Flow-mediated vasodilation (FMD), common carotid intima-media thickness (ccIMT) and pulse-wave velocity (PWV) were assessed by ultrasound. All assessments were performed at baseline, as well as 6 and 12 months after treatment initiation. Results: One-year anti-TNF therapy significantly decreased VEGF, PDGF-BB and Ang2 serum levels. In uni- and multivariate analyses, PDGF-BB levels correlated with smoking, disease duration and ccIMT. Moreover, Ang1 correlated with CRP, Ang2 with disease duration, CRP and positive CV history. Finally, TSP-1 levels correlated with disease duration, anti-CCP, anti-CEP and ccIMT. Conclusions: In our arthritis cohort, the levels of angiogenic markers correlated with disease duration, CRP, ACPA and ccIMT. Anti-TNF therapy attenuated the production of angiogenic markers in these arthritides. Some angiogenic mediators may be used as surrogate biomarkers that link angiogenesis, inflammation and atherosclerosis in arthritides.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
rheumatoid arthritis
angiogenesis
atherosclerosis
anti-TNF therapy
biomarkers
Megjelenés:Rheumatology and Orthopedic Medicine. - 4 (2019), p. 1-8. -
További szerzők:Végh Edit (1978-) (reumatológus, belgyógyász) Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Karancsiné Pusztai Anita (1989-) (tudományos segédmunkatárs) Hamar Attila Béla (1990-) (általános orvos) Hódosi Katalin Szamosi Szilvia (1975-) (belgyógyász, reumatológus) Váncsa Andrea (1972-) (orvos) Csomor Péter (1984-) (biotechnológus) Bodoki Levente (1986-) (PhD hallgató) Pogácsás Lilla Balázs Fruzsina Tar Ildikó (1967-) (fogszakorvos) McCormick, Jennifer Biniecka, Monika Fearon, Ursula Lundberg, Karin Kharlamova, Nastya Szántó Sándor (1968-) (belgyógyász, reumatológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nagy Zoltán (orvos) Veale, Douglas J. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Pályázati támogatás:TAMOP-4.2.4.A/2-11/1-2012-0001
TÁMOP
GINOP-2.3.2-15-2016-00050
GINOP
GINOP-2.3.2-15-2016-00015
GINOP
Internet cím:DOI
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5.

001-es BibID:BIBFORM007047
Első szerző:Biró Edit
Cím:Association of systemic and thyroid autoimmune diseases / Biro, E., Szekanecz, Z., Czirjak, L., Danko, K., Kiss, E., Szabo, N. A., Szucs, G., Zeher, M., Bodolay, E., Szegedi, G., Bako, G.
Dátum:2006
ISSN:0770-3198 (Print)
Megjegyzések:There are few large cohort studies available on the association of systemic and thyroid autoimmune diseases. In this study, we wished to determine the association of Hashimoto's thyroiditis (HT) and Graves' disease (GD) with systemic autoimmune diseases. METHODS: One thousand five hundred and seventeen patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), mixed connective tissue disease (MCTD), Sjogren's syndrome (SS) and polymyositis/dermatomyositis (PM/DM) were included in the study. The HT and GD were diagnosed based on thorough clinical evaluation, imaging and fine-needle aspiration cytology (FNAC). The frequency of HT and GD in these diseases was assessed. In addition, 426 patients with HT or GD were assessed and the incidence of SLE, RA, SSc, MCTD, SS and PM/DM among these patients was determined. Prevalence ratios indicating the prevalences of GD or HT among our autoimmune patients in comparison to prevalences of GD or HT in the general population were calculated. RESULTS: Altogether 8.2% of systemic autoimmune patients had either HT or GD. MCTD and SS most frequently overlapped with autoimmune thyroid diseases (24 and 10%, respectively). HT was more common among MCTD, SS and RA patients (21, 7 and 6%, respectively) than GD (2.5, 3 and 1.6%, respectively). The prevalences of HT in SLE, RA, SSc, MCTD, SS and PM/DM were 90-, 160-, 220-, 556-, 176- and 69-fold higher than in the general population, respectively. The prevalences of GD in the same systemic diseases were 68-, 50-, 102-, 76-, 74- and 37-fold higher than in the general population, respectively. Among all thyroid patients, 30% had associated systemic disease. In particular, 51% of HT and only 16% of GD subjects had any of the systemic disorders. MCTD, SS, SLE, RA, SSc and PM/DM were all more common among HT patients (20, 17, 7, 4, 2 and 2%, respectively) than in GD individuals (2, 5, 5, 1, 2 and 1%, respectively). CONCLUSION: Systemic and thyroid autoimmune diseases often overlap with each other. HT and GD may be most common among MCTD, SSc and SS patients. On the other hand, these systemic diseases are often present in HT subjects. Therefore it is clinically important to screen patients with systemic autoimmune diseases for the co-existence of thyroid disorders.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Arthritis, Rheumatoid
Autoimmune Diseases
Dermatomyositis
Female
Graves Disease
Hashimoto Disease
Humans
Lupus Erythematosus, Systemic
Male
Middle Aged
Mixed Connective Tissue Disease
Prevalence
Scleroderma, Systemic
Sjogren's Syndrome
Megjelenés:Clinical Rheumatology. - 25 : 2 (2006), p. 240-245. -
További szerzők:Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Czirják László Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Kiss Emese (1960-) (belgyógyász, immunológus) Szabó Nóra Anna (1976-) (orvos) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Bodolay Edit (1950-) (belgyógyász, allergológus és klinikai immunológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Bakó Gyula (1951-) (belgyógyász)
Internet cím:elektronikus változat
DOI
elektronikus változat
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6.

001-es BibID:BIBFORM015788
Első szerző:Bodnár Nóra (reumatológus)
Cím:Assessment of subclinical vascular disease associated with ankylosing spondylitis / Bodnár N., Kerekes G., Seres I., Paragh G., Kappelmayer J., Némethné Gyurcsik Zs., Szegedi G., Shoenfeld Y., Sipka S., Soltész P., Szekanecz Z., Szántó S.
Dátum:2011
ISSN:0315-162X
Megjegyzések:Studies indicate that ankylosing spondylitis (AS), as well as rheumatoid arthritis, may be associated with accelerated atherosclerosis and vascular disease. We assessed endothelial dysfunction, carotid atherosclerosis, and aortic stiffness in AS in context with clinical and laboratory measurements. METHODS: Forty-three patients with AS and 40 matched healthy controls were studied. We assessed common carotid intima-media thickness (ccIMT), flow-mediated vasodilation (FMD), and pulse-wave velocity (PWV) in association with age, disease duration, smoking habits, body mass index, patient's assessment of pain and disease activity, Bath AS Disease Activity Index, Bath AS Functional Index (BASFI), metric measurements, erythrocyte sedimentation rate, C-reactive protein, and HLA-B27 status. RESULTS: We found impaired FMD (6.85 +/- 2.98% vs 8.30 +/- 3.96%; p = 0.005), increased ccIMT (0.65 +/- 0.15 vs 0.54 +/- 0.15 mm; p = 0.01), and higher PWV (8.64 +/- 2.44 vs 8.00 +/- 1.46 m/s; p = 0.03) in patients with AS compared to controls, respectively. We also found that ccIMT negatively correlated with FMD (r = -0.563; p = 0.0001) and positively correlated with PWV (r = 0.374; p = 0.018). Both ccIMT and PWV correlated with disease duration (r = 0.559; p = 0.013 and r = 0.520; p = 0.022, respectively), BASFI (r = 0.691; p = 0.003 and r = 0.654; p = 0.006), decreased lumbar spine mobility (r = -0.656; p = 0.006 and r = -0.604; p = 0.013), chest expansion (r = -0.502; p = 0.047 and r = -0.613; p = 0.012), and increased wall-occiput distance (r = 0.509; p = 0.044 and r = 0.614; p = 0.011). CONCLUSION: In this well characterized AS population, impaired FMD and increased ccIMT and PWV indicate abnormal endothelial function and increased atherosclerosis and aortic stiffness, respectively. The value of noninvasive diagnostic tools needs to be further characterized.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Rheumatology. - 38 : 4 (2011), p. 723-729. -
További szerzők:Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Kappelmayer János (1960-) (laboratóriumi szakorvos) Némethné Gyurcsik Zsuzsanna (1976-) (gyógytornász) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Shoenfeld, Yehuda Sipka Sándor (1945-) (laboratóriumi szakorvos) Soltész Pál (1961-) (belgyógyász, kardiológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szántó Sándor (1968-) (belgyógyász, reumatológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
elektronikus elérés
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7.

001-es BibID:BIBFORM038689
035-os BibID:PMID:15301236
Első szerző:Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:Anti-endothelial cell antibodies in mixed connective tissue disease : frequency and association with clinical symptoms / E. Bodolay, I. Csipő, I. Gál, S. Sipka, E. Gyimesi, Z. Szekanecz, G. Szegedi
Dátum:2004
Megjegyzések:AbstractOBJECTIVE: Anti-endothelial cell antibodies (AECA) have been described in a number of systemic autoimmune-inflammatory diseases. However, little is known about the relationship of AECA with mixed connective tissue disease (MCTD).METHODS: Using an ELISA, the presence of AECA was evaluated in the sera of 33 patients with MCTD and of 30 healthy subjects as controls. Serum levels of AECA were correlated with clinical activity, as well as the existence of various organ manifestations.RESULTS: Significantly increased AECA production was observed in MCTD patients (OD = 0.337+/-0.193) compared to controls (OD = 0.136+/-0.065). In addition, patients with active MCTD exerted significantly elevated serum AECA levels (OD = 0.487+/-0.090) than did patients with inactive MCTD (OD = 0.135+/-0.040) or controls. MCTD patients with pulmonary hypertension had a tendency of increased serum AECA levels (OD = 0.452+/-0.080) compared to patients without this manifestation (OD = 0.307+/-0.039). Sera of MCTD patients with AECA concentrations higher or lower than the mean serum AECA level in controls+2SD (OD = 0.266) were considered as AECAhigh (n = 19/33) and AECAlow (n = 14/33), respectively. Interestingly, all patients with active disease had AECAhigh, while all inactive MCTD patients had AECAlow sera. IgG purified from ten MCTD sera (OD = 0.415+/-0.290) showed a tendency to up-regulate E-selectin expression on cultured human umbilical vein endothelial cells (HUVEC) compared to IgG from control sera. In addition, AECAhigh MCTD sera exerted significantly increased stimulatory effect on endothelial E-selectin expression (OD = 0.651+/-0.190) compared to AECAlow (OD = 0.178+/-0.110) or control sera (OD = 0. 131+/-0.080).CONCLUSION: AECA may activate endothelial cells by the up-regulation of E-selectin expression and thus may be implicated in the pathogenesis of MCTD. Furthermore, serum AECA may be a useful marker of endothelial activation and clinical activity in this disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
anti-endothelial antibodies
mixed connective tissue disease
symptoms
Adult
Autoantibodies
Cells, Cultured
Dose-Response Relationship, Immunologic
E-Selectin
Endothelial Cells
Endothelium, Vascular
Enzyme-Linked Immunosorbent Assay
Female
Humans
Hypertension, Pulmonary
Immunoglobulin G
Male
Middle Aged
Mixed Connective Tissue Disease
egyetemen (Magyarországon) készült közlemény
Megjelenés:Clinican and Experimental Rheumatology. - 22 : 4 (2004), p. 409-415. -
További szerzők:Csípő István (1953-) (vegyész) Gál I. Sipka Sándor (1945-) (laboratóriumi szakorvos) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

8.

001-es BibID:BIBFORM007052
Első szerző:Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:Meningitis in mixed connective tissue disease complicated by herpes virus infection : case report / Bodolay, E., Dioszeghy, P., Demeter, J., Banyai, A., Csipo, I., Szegedi, G., Szekanecz, Z.
Dátum:2004
ISSN:0172-8172 (Print)
Megjegyzések:The authors report a rare case of a female patient diagnosed with mixed connective tissue disease (MCTD). After a few years in remission, the patient acquired herpes zoster infection followed by a disease flare. Disease activity was accompanied by the development of meningitis. To determine whether the meningitis was caused by the previous herpes virus infection or was aseptic meningitis associated with the activity of MCTD raised important differential diagnostic issues. Repeated laboratory assessments of the patient's sera and cerebrospinal fluid revealed leukocytopenia, high anti-U1 ribonucleoprotein autoantibody level, increased immune complex, and decreased complement concentrations. The administration of corticosteroids resulted in rapid improvements in clinical symptoms and laboratory indicators.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adrenal Cortex Hormones
Adult
Female
Follow-Up Studies
Herpes Zoster
Humans
Meningitis, Aseptic
Mixed Connective Tissue Disease
Risk Assessment
Severity of Illness Index
Treatment Outcome
Megjelenés:Rheumatology International. - 24 : 6 (2004), p. 359-361. -
További szerzők:Diószeghy Péter (1948-) (ideg- és elmeszakorvos) Demeter József Bányai Anikó Csípő István (1953-) (vegyész) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:elektronikus változat
DOI
elektronikus változat
Borító:

9.

001-es BibID:BIBFORM007050
Első szerző:Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:Five-year follow-up of 665 Hungarian patients with undifferentiated connective tissue disease (UCTD) / Bodolay, E., Csiki, Z., Szekanecz, Z., Ben, T., Kiss, E., Zeher, M., Szucs, G., Danko, K., Szegedi, G.
Dátum:2003
ISSN:0392-856X (Print)
Megjegyzések:To determine the clinical symptoms and the panel of autoantibodies of patients with early undifferentiated connective tissue disease (UCTD) followed for at least 1 year. METHODS: 716 UCTD patients with manifestations suggestive but not diagnostic of specific connective tissue disease (CTD) were recruited and followed up between 1994-1999. The patients with early UCTD were subdivided into those with isolated Raynaud's phenomenon (RP) (50 patients), unexplained polyarthritis (31 patients) and "true" UCTD (665 patients). UCTD was diagnosed on the basis of clinical manifestations suggestive of a connective tissue disease and the presence of at least one non-organ specific autoantibody. The patients' sera were tested for anti-nuclear (ANA), as well as for nine different specific autoantibodies (anti-dsDNA, -Sm, -RNP, -SSA, -SSB, -Scl-70, -centromere, -Jo1 and -PM-Scl). RESULTS: The most common clinical manifestations of UCTD included RP, arthritis/arthralgias, pleuritis/pericarditis, sicca symptoms, cutaneous involvement (photosensitivity, rash), central nervous symptoms, peripheral neuropathy, fever, vasculitis, less pulmonary involvement and myositis. 230 of the 665 true UCTD patients (34.5%) developed a defined CTD (28 systemic lupus erythematosus [SLE], 26 mixed connective tissue disease [MCTD], 19 progressive systemic sclerosis [PSS], 45 Sjogren's syndrome, 3 polymyositis/dermatomyositis [PM/DM], 87 rheumatoid arthritis [RA], and 22 systemic vasculitis. 435 of 665 patients (65.4%) remained in the UCTD state, and 82 of 665 patients (12.3%) achieved complete remission with symptoms not reappearing within the 5-year period. The highest probability of evolution to a defined CTD was during the first 2 years after onset: of 230 UCTD patients 183 (79.5%) developed major organ symptoms and signs. In particular skin and cardiac complications seemed to spread during the follow-up period in those patients who progressed to SLE. The condition of 18/50 patients with isolated RP evolved to UCTD and 3 of 31 patients with unexplained polyarthritis progressed to definite CTD (2 patients RA and one MCTD). CONCLUSION: In our study most of the UCTD patients did not develop a definite CTD, but during the follow-up period we found new clinical and serological manifestations. One-third of the UCTD patients showed progress into different types of specific CTD.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adolescent
Adult
Aged
Autoantibodies
Autoimmunity
Cohort Studies
Confidence Intervals
Connective Tissue Diseases
Disease Progression
Female
Follow-Up Studies
Humans
Hungary
Logistic Models
Lupus Erythematosus, Systemic
Male
Middle Aged
Polymyositis
Probability
Prognosis
Retrospective Studies
Scleroderma, Systemic
egyetemen (Magyarországon) készült közlemény
Severity of Illness Index
Sjogren's Syndrome
Time Factors
Vasculitis
Megjelenés:Clinical and Experimental Rheumatology. - 21 : 3 (2003), p. 313-320. -
További szerzők:Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Ben, Thomas Kiss Emese (1960-) (belgyógyász, immunológus) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
Internet cím:elektronikus változat
Borító:

10.

001-es BibID:BIBFORM007049
Első szerző:Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:Osteoporosis in mixed connective tissue disease / Bodolay, E., Bettembuk, P., Balogh, A., Szekanecz, Z.
Dátum:2003
ISSN:0770-3198 (Print)
Megjegyzések:The existence of osteoporosis in 58 postmenopausal women with mixed connective tissue disease (MCTD) was investigated. The mean bone mineral density assessed by dual energy X-ray absorptiometry in the lumbar spine was decreased in 25.8% of the patients, reflecting osteoporosis (T score < -2.5). In the femoral neck there was no significant difference between the BMD of MCTD patients and that of age-matched, healthy postmenopausal women. Low bone mineral density was found among patients on, as well as off, corticosteroids. The extent of bone loss was associated with disease duration, as well as corticosteroid therapy. Serum osteocalcin levels were lower in MCTD patients than in controls. Lower serum oestradiol, testosterone and dehydroepiandrosterone sulphate levels were detected in MCTD patients than in controls. Thus, MCTD may be associated with increased bone loss. Pathogenic factors may include the disease itself, corticosteroid therapy, impaired osteoblast function, and low serum sex hormone levels.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Absorptiometry, Photon
Age Distribution
Aged
Bone Density
Case-Control Studies
Cohort Studies
Comorbidity
Estrogens
Female
Humans
Incidence
Middle Aged
Mixed Connective Tissue Disease
Osteocalcin
Osteoporosis, Postmenopausal
Probability
Prognosis
Severity of Illness Index
Statistics, Nonparametric
egyetemen (Magyarországon) készült közlemény
Megjelenés:Clinical Rheumatology. - 22 : 3 (2003), p. 213-217. -
További szerzők:Bettembuk Péter Balogh Á. (orvos) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:elektronikus változat
DOI
elektronikus változat
Borító:

11.

001-es BibID:BIBFORM007054
Első szerző:Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD) / Bodolay, E., Szekanecz, Z., Devenyi, K., Galuska, L., Csipo, I., Vegh, J., Garai, I., Szegedi, G.
Dátum:2005
ISSN:1462-0324
Megjegyzések:Interstitial lung disease (ILD) may be a characteristic, often serious, manifestation of mixed connective tissue disease (MCTD). In this retrospective study, the frequency and clinical picture of ILD were determined in patients with MCTD using two diagnostic tests: high-resolution computed tomography (HRCT) and inhaled aerosol clearance times of (99m)Tc-labelled diethylene-triamine pentaacetate ((99m)Tc-DTPA). In addition, pulmonary function, effects of therapy and a variety of immunoserological markers were also assessed. METHODS: One hundred and forty-four consecutive patients with MCTD were selected from the clinic, irrespective of the presence or absence of ILD. All patients underwent a detailed clinical assessment, chest HRCT scanning, chest radiography, inhaled aerosol of (99m)Tc-DTPA clearance times, and all pulmonary function tests. Patients who had active ILD received corticosteroid (CS) or CS in combination with cyclophosphamide (CPH). All investigations were repeated after 6 months of immunosuppressive therapy. RESULTS: Ninety-six out of 144 MCTD patients (66.6%) had active ILD, 75 of this group (78.1%) showed ground glass opacity, 21 patients (21.8%) ground glass opacity with mild fibrosis with HRCT. Forty-five patients with active ILD received 2 mg/kg/day CS for 6-8 weeks alone and 51 patients CS in combination with CPH (2 mg/kg/day). Six months later, after therapy, 67 out of 96 MCTD patients with ILD (69.8%) showed a negative HRCT pattern, ground glass opacity with mild fibrosis developed in 15 patients (15.6%), and fibrosis was detected in 13 patients (13.5%). Only one patient showed subpleural honeycombing. (99m)Tc-DTPA was rapid in all 96 MCTD patients with active ILD (28.7 +/- 8.2 min, normal value >40 min). After therapy the (99m)Tc-DTPA was normalized, 79 out of 96 patients (82.3%). Carbon monoxide diffusion capacity (DLCO) was reduced in 33 out of 96 MCTD patients with active ILD (34.3%), while there were no significant differences in the pulmonary function tests between the active versus inactive stage of ILD or versus patients without ILD. The sera of 96 MCTD patients with active ILD contained a high level of immune complexes (ICs), and the total haemolytic complement levels (CH50/ml U) decreased. After 6 months of therapy, the IC levels decreased and CH50/ml levels normalized (MCTD patients before and after active ILD: IC optical density = 355 +/- 227 vs 206 +/- 92, P<0.001; CH50/ml, 38.0 +/- 12.6 U vs 64.3 +/- 13.0 U, P<0.001). CONCLUSIONS: HRCT is the gold standard for diagnosis of ILD. However, we used another method, (99m)Tc-DTPA, in order to compare this technique with HRCT. This latter technique has not been studied previously in MCTD. The elevated levels of IC and increased complement consumption indicated that IC-mediated alveolocapillary membrane damage and tissue injury might play a role in the pathogenesis of ILD in MCTD.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adult
Aged
Cyclophosphamide
Drug Therapy, Combination
Female
Glucocorticoids
Humans
Lung Diseases, Interstitial
imaging
Male
Methylprednisolone
Middle Aged
Mixed Connective Tissue Disease
Radiopharmaceuticals
Respiratory Function Tests
Retrospective Studies
Technetium Tc 99m Pentetate
Tomography, X-Ray Computed
egyetemen (Magyarországon) készült közlemény
Megjelenés:Rheumatology (Oxford). - 44 : 5 (2005), p. 656-661. -
További szerzők:Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Dévényi Katalin Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Csípő István (1953-) (vegyész) Végh Judit (1968-) (belgyógyász, kardiológus) Garai Ildikó (1966-) (radiológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
Internet cím:elektronikus változat
elektronikus változat
DOI
Borító:

12.

001-es BibID:BIBFORM082696
035-os BibID:(WOS)000518552700007 (Scopus)85080842334
Első szerző:Borbásné Sebestyén Veronika (biofizikus)
Cím:Electrocardiographic markers for the prediction of ventricular arrhythmias in patients with systemic sclerosis / Veronika Sebestyén, Gabriella Szűcs, Dénes Páll, Dóra Ujvárosy, Tamás Ötvös, Imre Csige, Tamás Pataki, István Lőrincz, Zoltán Szabó
Dátum:2020
ISSN:1462-0324 1462-0332
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Rheumatology. - 59 : 3 (2020), p. 478-486. -
További szerzők:Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Páll Dénes (1967-) (belgyógyász, kardiológus) Ujvárosy Dóra (1985-) Ötvös Tamás (1980-) (orvos) Csige Imre (1985-) (orvos) Pataki Tamás Lőrincz István (1950-) (belgyógyász, kardiológus) Szabó Zoltán (1973-) (belgyógyász, kardiológus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00062
GINOP
Internet cím:Szerző által megadott URL
DOI
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