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001-es BibID:	BIBFORM060629
Első szerző:	Friedrich Péter
Cím:	Protein cross-linking by transglutaminase induced in long-term potentiation in the Ca1 region of hippocampal slices / P. Friedrich, L. Fesus, E. Tarcsa, G. Czéh
Dátum:	1991
ISSN:	0306-4522
Megjegyzések:	Long-term potentiation induced by high-frequency stimulation of Schaffer collaterals in slices of rat hippocampus is accompanied by protein cross-linking by the Ca(2+)-dependent enzyme transglutaminase. This conclusion was drawn from the accumulation of the "isodipeptide" epsilon(gamma-glutamyl)lysine in the proteolytic digests of tetanized, but not of control, slices. The isopeptide bond is formed by transglutaminase between glutamyl-gamma-CONH2 and lysyl-epsilon-NH2 groups of proteins. It is suggested that the Ca(2+-induced covalent cross-linking of neuronal, probably dendritic, proteins may be part of the mechanism of long-term plastic changes via stabilization of newly formed supramolecular protein assemblies at the synapse.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neuroscience 43 : 2-3 (1991), p. 331-334. -
További szerzők:	Fésüs László (1947-) (orvos biokémikus) Tarcsa Edit Czéh Gábor
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM075780
035-os BibID:	(WoS)000442995700011 (Scopus)85052649921
Első szerző:	Simándi Zoltán (Ph.D. hallgató, molekuláris biológus)
Cím:	Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons / Zoltan Simandi, Krisztian Pajer, Katalin Karolyi, Tatiana Sieler, Lu-Lin Jiang, Zsuzsanna Kolostyak, Zsanett Sari, Zoltan Fekecs, Attila Pap, Andreas Patsalos, Gerardo Alvarado Contreras, Balint Reho, Zoltan Papp, Xiufang Guo, Attila Horvath, Greta Kiss, Zsolt Keresztessy, György Vámosi, James Hickman, Huaxi Xu, Dorothee Dormann, Tibor Hortobagyi, Miklos Antal, Antal Nógrádi, Laszlo Nagy
Dátum:	2018
Tárgyszavak:	idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	The Journal of neuroscience. - 38 : 35 (2018), p. 7683-7700. -
További szerzők:	Pájer Krisztián Károlyi Katalin Sieler, Tatiana Jiang, Lu-Lin Kolostyák Zsuzsanna Sári Zsanett (1991-) (klinikai laboratóriumi kutató) Fekecs Zoltán Pap Attila (1980-) (biológus) Patsalos, Andreas Contreras, Gerardo Alvarado (1978-) (orvos) Rehó Bálint (1992-) Papp Zoltán (1965-) (kardiológus, élettanász) Guo, Xiufang Horváth Attila (1988-) (programtervező informatikus) Kiss Gréta Keresztessy Zsolt Vámosi György (1967-) (biofizikus) Hickman, James Xu, Huaxi Dormann, Dorothee Hortobágyi Tibor (1965-) (patológus) Antal Miklós (1951-) (orvos, anatómus) Nógrádi Antal Nagy László (1966-) (molekuláris sejtbiológus, biokémikus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00043 GINOP 116855 OTKA 124298 OTKA 126885 OTKA TAMOP 422_2012_0023 VÉD-ELEM TÁMOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL DOI
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001-es BibID:	BIBFORM039786
Első szerző:	Vadász Csaba
Cím:	Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes / Vadasz, C., Smiley, J. F., Figarsky, K., Saito, M., Toth, R., Gyetvai, B. M., Oros, M., Kovacs, K. K., Mohan, P., Wang, R.
Dátum:	2007
ISSN:	0306-4522
Megjegyzések:	The mesotelencephalic dopamine system shows substantial genetic variation which fundamentally affects normal and pathological behaviors related to motor function, motivation, and learning. Our earlier radioenzyme assay studies demonstrated significantly higher activity of tyrosine hydroxylase (TH), the first and rate limiting enzyme in the biosynthesis of catecholamine neurotransmitters, in the substantia nigra-ventral tegmental area of BALB/cJ mice in comparison with that of C57BL/6ByJ mice. Here, using quantitative immunoblotting and immunocytochemistry, we tested the hypothesis that mesencephalic TH protein content and number of nigral TH-positive neurons show strain-dependent differences in C57BL/6ByJ and BALB/cJ parallel to those observed in the TH activity studies. Immunoblotting experiments detected significantly higher mesencephalic TH protein content in BALB/cJ in comparison to C57BL/6ByJ (P<0.05). Immunocytochemical studies demonstrated that the number of TH-positive cells in substantia nigra was 31.3% higher in BALB/cJ than that in C57BL/6ByJ (P<0.01), while the average dopamine neuron volume was not significantly different. In a search for candidate genes that modulate TH content and the size of mesencephalic dopamine neuron populations we also studied near-isogenic mouse sublines derived from the C57BL/6ByJ and BALB/cJ progenitor strains. A whole-genome scan with 768 single nucleotide polymorphism markers indicated that two sublines, C4A6/N and C4A6/B, were genetically very similar (98.3%). We found significantly higher mesencephalic TH protein content in C4A6/B in comparison to C4A6/N (P=0.01), and a tendency for higher number of dopamine neurons in the substantia nigra in C4A6/B in comparison to C4A6/N, which, however, did not reach statistical significance. To identify the genetic source of the TH content difference we analyzed the single nucleotide polymorphism (SNP) genotype data of the whole-genome scan, and detected two small differential chromosome segments on chr. 13 and chr. 14. Microarray gene expression studies and bioinformatic analysis of the two differential regions implicated two cis-regulated genes (Spock1 and Cxcl14, chr. 13), and two growth factor genes [bone morphogenetic protein 6 (Bmp6) (chr. 13), and fibroblast growth factor 14 (Fgf14) (chr. 14)]. Taken together, the results suggest that (1) nigral dopamine neuron number and TH protein content may be genetically associated but further studies are needed to establish unequivocally this linkage, and (2) Spock1, Cxcl14, Bmp6, and Fgf14 are novel candidates for modulating the expression and maintenance of TH content in mesencephalic dopamine neurons in vivo.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neuroscience. - 149 : 3 (2007), p. 561-572. -
További szerzők:	Smiley, John Figarsky, K. Saito, Mariko Tóth Réka Gyetvai Beatrix Oros Melinda (1975-) (molekuláris biológus) Kovács, K. K. Mohan, Puneet Wang, Rui
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