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001-es BibID:	BIBFORM080730
035-os BibID:	(cikkazonosító)2084 (WoS)000487964600293 (Scopus)85071762937 (PMID)31487780
Első szerző:	Aydemir, Gamze (biotechnológus)
Cím:	Apo-14'-Carotenoic Acid Is a Novel Endogenous and Bioactive Apo-Carotenoid / Gamze Aydemir, Marta Domínguez, Angel R. de Lera, Johanna Mihaly, Dániel Törőcsik, Ralph Rühl
Dátum:	2019
ISSN:	2072-6643
Megjegyzések:	Carotenoids can be metabolized to various apo-carotenoids and retinoids. Apo-15?-carotenoic acid (retinoic acid, RA) is a potent activator of the retinoic acid receptor (RAR) in its all-trans- (ATRA) and 9-cis- (9CRA) forms. In this study we show firstly, that apo-14?-carotenoic acid (A14CA), besides retinoic acids, is present endogenously and with increased levels in the human organism after carrot juice supplementation rich in β-carotene. All-trans-A14C (ATA14CA) is just a moderate activator of RAR-transactivation in reporter cell lines but can potently activate retinoic acid response element (RARE)-mediated signalling in DR5/RARE-reporter mice and potently increase retinoid-reporter target gene expression in ATA14CA-supplemented mice and treated MM6 cells. Further metabolism to all-trans-13,14-dihydroretinoic acid (ATDHRA) may be the key for its potent effects on retinoid target gene activation in ATA14CA-treated MM6 cells and in liver of supplemented mice. We conclude that besides RAs, there are alternative ways to activate RAR-response pathways in the mammalian organism. ATA14CA alone and in combination with its metabolite ATDHRA may be an alternative pathway for potent RAR-mediated signalling.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk apo-carotenoids carotene retinoic acid vitamin A
Megjelenés:	Nutrients. - 11 : 9 (2019), p. 1-11. -
További szerzők:	Domínguez, Marta de Lera, Ángel R. Mihály Johanna (1982-) (biológus, vegyész) Töröcsik Dániel (1979-) (bőrgyógyász) Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM113710
035-os BibID:	(cikkazonosító)3315 (WoS)001046283500001 (Scopus)85167680789
Első szerző:	Kovács Dóra (Biológus)
Cím:	Linoleic Acid Induced Changes in SZ95 Sebocytes-Comparison with Palmitic Acid and Arachidonic Acid / Dóra Kovács, Emanuela Camera, Szilárd Póliska, Alessia Cavallo, Miriam Maiellaro, Katalin Dull, Florian Gruber, Christos C. Zouboulis, Andrea Szegedi, Dániel Törőcsik
Dátum:	2023
ISSN:	2072-6643
Megjegyzések:	Linoleic acid (LA) is an essential omega-6 polyunsaturated fatty acid (PUFA) derived from the diet. Sebocytes, whose primary role is to moisturise the skin, process free fatty acids (FFAs) to produce the lipid-rich sebum. Importantly, like other sebum components such as palmitic acid (PA), LA and its derivative arachidonic acid (AA) are known to modulate sebocyte functions. Given the different roles of PA, LA and AA in skin biology, the aim of this study was to assess the specificity of sebocytes for LA and to dissect the different roles of LA and AA in regulating sebocyte functions. Using RNA sequencing, we confirmed that gene expression changes in LA-treated sebocytes were largely distinct from those induced by PA. LA, but not AA, regulated the expression of genes related to cholesterol biosynthesis, androgen and nuclear receptor signalling, keratinisation, lipid homeostasis and differentiation. In contrast, a set of mostly down-regulated genes involved in lipid metabolism and immune functions overlapped in LA- and AA-treated sebocytes. Lipidomic analyses revealed that the changes in the lipid profile of LA-treated sebocytes were more pronounced than those of AA-treated sebocytes, suggesting that LA may serve not only as a precursor of AA but also as a potent regulator of sebaceous lipogenesis, which may not only influence the gene expression profile but also have further specific biological relevance. In conclusion, we have shown that sebocytes are able to respond selectively to different lipid stimuli and that LA-induced effects can be both AA-dependent and independent. Our findings allow for the consideration of LA application in the therapy of sebaceous gland-associated inflammatory skin diseases such as acne, where lipid modulation and selective targeting of AA metabolism are potential treatment options.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Nutrients. - 15 : 15 (2023), p. 1-20. -
További szerzők:	Camera, Emanuela Póliska Szilárd (1978-) (biológus) Cavallo, Alessia Maiellaro, Miriam Dull Katalin (1983-) (molekuláris biológus, genetikus) Gruber, Florian Zouboulis, Christos C. (1960-) (bőrgyógyász) Szegedi Andrea (1964-) (bőrgyógyász) Töröcsik Dániel (1979-) (bőrgyógyász)
Pályázati támogatás:	FK-132296 OTKA ANN 139589 OTKA K-128250 OTKA Italian Ministry of Health Egyéb FWF Austrian Science Fund; I 5627-B Egyéb
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM096580
035-os BibID:	(cikkazonosító)2409 (WoS)000676356300001 (Scopus)85109904667
Első szerző:	Kovács Elek Gergő
Cím:	Caffeine Has Different Immunomodulatory Effect on the Cytokine Expression and NLRP3 Inflammasome Function in Various Human Macrophage Subpopulations / Elek Gergő Kovács, Ahmad Alatshan, Marietta Margit Budai, Zsolt Czimmerer, Eduárd Bíró, Szilvia Benkő
Dátum:	2021
ISSN:	2072-6643
Megjegyzések:	Besides its well-known psychoactive effects, caffeine has a broad range of actions. It regulates several physiological mechanisms as well as modulates both native and adaptive immune responses by various ways. Although caffeine is assumed to be a negative regulator of inflammation, the effect on the secretion of pro- and anti-inflammatory cytokines is highly controversial. Macrophages are major mediators of inflammatory responses; however, the various subpopulations develop different effects ranging from the initiation to the resolution of inflammation. Here we report a comparative analysis of the effect of caffeine on two subpopulations of human monocyte-derived macrophages differentiated in the presence of macrophage colony-stimulating factor (M-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF), resulting in M-M?s and GM-M?s, respectively. We showed that although TNF-? secretion was downregulated in both LPS-activated M? subtypes by caffeine, the secretion of IL-8, IL-6, and IL-1? as well as the expression of Nod-like receptors was enhanced in M-M?s, while it did not change in GM-M?s. We showed that caffeine (1) altered adenosine receptor expression, (2) changed Akt/AMPK/mTOR signaling pathways, and (3) inhibited STAT1/IL-10 signaling axis in M-M?s. We hypothesized that these alterations play an important modulatory role in the upregulation of NLRP3 inflammasome-mediated IL-1? secretion in LPS-activated M-M?s following caffeine treatment.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk caffeine inflammation macrophages NLRP3 inflammasome cytokines signaling
Megjelenés:	Nutrients. - 13 : 7 (2021), p. 2409. -
További szerzők:	Alatshan, Ahmad (1984-) (immunológus) Budai Marietta Margit (1985-) (molekuláris biológus) Czimmerer Zsolt (1981-) (molekuláris biológus) Bíró Eduárd (1998-) (molekuláris biológus) Benkő Szilvia (1973-) (molekuláris biológus)
Pályázati támogatás:	K131844 OTKA FK132185 OTKA GINOP-2.3.2-15-2016-00040 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM075443
035-os BibID:	(cikkazonosító)1390 (WoS)000448821300056 (Scopus)85054091771
Első szerző:	Lucas, Renata
Cím:	Reduced Carotenoid and Retinoid Concentrations and Altered Lycopene Isomer Ratio in Plasma of Atopic Dermatitis Patients / Lucas Renata, Mihály Johanna, Lowe Gordon, Graham Daniel, Szklenar Monika, Szegedi Andrea, Töröcsik Daniel, Rühl Ralph
Dátum:	2018
ISSN:	2072-6643
Megjegyzések:	Abstract: Carotenoids and retinoids are known to alter the allergic response with important physiological roles in the skin and the immune system. In the human organism various carotenoids are present, some of which are retinoid precursors. The bioactive derivatives of these retinoids are the retinoic acids, which can potently activate nuclear hormone receptors such as the retinoic acid receptor and the retinoid X receptor. In this study, we aimed to assess how plasma carotenoid and retinoid concentrations along with the ratio of their isomers are altered in atopic dermatitis (AD) patients (n = 20) compared to healthy volunteers (HV, n = 20). The study indicated that plasma levels of the carotenoids lutein (HV 198 14 ng/mL, AD 158 12 ng/mL, p = 0.02; all values in mean SEM), zeaxanthin (HV 349 30 ng/mL, AD 236 18 ng/mL, p 0.01), as well as the retinoids retinol (HV 216 20 ng/mL, AD 167 17 ng/mL, p = 0.04) and all-trans-retinoic acid (HV 1.1 0.1 ng/mL, AD 0.7 0.1 ng/mL, p = 0.04) were significantly lower in the AD-patients, while lycopene isomers, -carotene, and -carotene levels were comparable to that determined in the healthy volunteers. In addition, the ratios of 13-cis- vs. all-trans-lycopene (HV 0.31 0.01, AD 0.45 0.07, p = 0.03) as well as 13-cis- vs. all-trans-retinoic acid (HV 1.4 0.2, AD 2.6 0.6, p = 0.03) were increased in the plasma of AD-patients indicating an AD-specific 13-cis-isomerisation. A positive correlation with SCORAD was calculated with 13-cis- vs. all-trans-lycopene ratio (r = 0.40, p = 0.01), while a negative correlation was observed with zeaxanthin plasma levels (r = ??0.42, p = 0.01). Based on our results, we conclude that in the plasma of AD-patients various carotenoids and retinoids are present at lower concentrations, while the ratio of selected lycopene isomers also differed in the AD-patient group. An increase in plasma isomers of both lycopene and retinoic acid may cause an altered activation of nuclear hormone receptor signaling pathways and thus may be partly responsible for the AD-phenotype.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk lycopene carotene retinoic acid retinoid vitamin A RAR RXR
Megjelenés:	Nutrients. - 10 : 10 (2018), p. 1-12. -
További szerzők:	Mihály Johanna (1982-) (biológus, vegyész) Lowe, Gordon Graham, Daniel Szklenár Mónika Szegedi Andrea (1964-) (bőrgyógyász) Töröcsik Dániel (1979-) (bőrgyógyász) Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP K109362 OTKA K 128250 NKFIH
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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