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001-es BibID:BIBFORM113573
035-os BibID:(cikkazonosító)7560 (Scopus)85158000408 (WoS)000977406500001
Első szerző:Drezek, Karolina
Cím:Valorisation of Whey Permeate in Sequential Bioprocesses towards Value-Added Products?Optimisation of Biphasic and Classical Batch Cultures of Kluyveromyces marxianus / Karolina Drȩżek, Maria Krystyna Sobczyk, Zoltán Kállai, Anna Detman, Paula Bardadyn, Jolanta Mierzejewska
Dátum:2023
ISSN:1422-0067
Megjegyzések:Whey permeate is categorised as hazardous wastewater for aquatic environments, mainly due to its high lactose content. Therefore, it must be valorised before being released into the environment. One pathway for whey permeate management is its use in biotechnological processes. Herein, we present roads for whey permeate valorisation with the K. marxianus WUT240 strain. The established technology is based on two bioprocesses. During first, 2.5 g/L 2-phenylethanol and fermented plant oils enriched with different flavourings are obtained after 48 h biphasic cultures at 30 ?C. The second process leads to a maximum of 75 g ethanol/L (YP/S = 0.53 g/g) after 96 h at 30 ?C. Moreover, established whey permeate valorisation pathways reduced its biochemical oxygen demand and chemical oxygen demand values by 12- to 3-fold, respectively. Together, the present study reports a complete, effective, and environmentally friendly whey permeate management strategy while simultaneously enabling the acquisition of valuable compounds with substantial application potential.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
whey permeate
valorisation
Kluyveromyces marxianus
2-phenylethanol
ethanol
Megjelenés:International Journal Of Molecular Sciences. - 24 : 8 (2023), p. 1-17. (cikkazonosító)7560. -
További szerzők:Sobczyk, Maria Krystyna Kállai Zoltán (1986-) (biológus) Detman, Anna Bardadyn, Paula Mierzejewska, Jolanta
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001-es BibID:BIBFORM099884
035-os BibID:(cikkazonosító)1037 (scopus)85122862338 (wos)000754896600001
Első szerző:Kiss Mariann (vegyész)
Cím:2-Acetamido-2-deoxy-d-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes / Mariann Kiss, István Timári, Teréz Barna, Zuzana Mészáros, Kristýna Slámová, Pavla Bojarová, Vladimír Křen, Joseph M. Hayes, László Somsák
Dátum:2022
ISSN:1661-6596 1422-0067
Megjegyzések:Inhibition of the human O-linked ?-N-acetylglucosaminidase (hOGA, GH84) enzyme is pharmacologically relevant in several diseases such as neurodegenerative and cardiovascular disorders, type 2 diabetes, and cancer. Human lysosomal hexosaminidases (hHexA and hHexB, GH20) are mechanistically related enzymes; therefore, selective inhibition of these enzymes is crucial in terms of potential applications. In order to extend the structure?activity relationships of OGA inhibitors, a series of 2-acetamido-2-deoxy-D-glucono-1,5-lactone sulfonylhydrazones was prepared from D-glucosamine. The synthetic sequence involved condensation of N-acetyl-3,4,6-tri-O-acetylD-glucosamine with arenesulfonylhydrazines, followed by MnO2 oxidation to the corresponding glucono-1,5-lactone sulfonylhydrazones. Removal of the O-acetyl protecting groups by NH3/MeOH furnished the test compounds. Evaluation of these compounds by enzyme kinetic methods against hOGA and hHexB revealed potent nanomolar competitive inhibition of both enzymes, with no significant selectivity towards either. The most efficient inhibitor of hOGA was 2-acetamido-2-deoxyD-glucono-1,5-lactone 1-naphthalenesulfonylhydrazone (5f, Ki = 27 nM). This compound had a Ki of 6.8 nM towards hHexB. To assess the binding mode of these inhibitors to hOGA, computational studies (Prime protein?ligand refinement and QM/MM optimizations) were performed, which suggested the binding preference of the glucono-1,5-lactone sulfonylhydrazones in an s-cis conformation for all test compounds.
Tárgyszavak:Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
hOGA
hHexB
inhibitor
glyconolactone sulfonylhydrazone
Prime refinement
QM/MM optimization
Megjelenés:International Journal of Molecular Sciences. - 23 : 3 (2022), p. 1-18. --
További szerzők:Timári István (1989-) (vegyész) Barna Teréz (1963-) (vegyész) Mészáros, Zuzana Slámová, Kristýna Bojarová, Pavla Křen, Vladimír Hayes, Joseph M. Somsák László (1954-) (vegyész)
Pályázati támogatás:K109450
OTKA
FK-125067
OTKA
PD 135034
OTKA
GINOP-2.3.2-15-2016-00008
GINOP
GINOP-2.3.3-15-2016-00004
GINOP
ÚNKP-21-5-DE-471
Egyéb
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