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001-es BibID:	BIBFORM084841
035-os BibID:	(cikkazonosító)P 103
Első szerző:	Csire Gizella (vegyész)
Cím:	Metal ion catalyzed oxidation of a human prion fragment / Gizella Csire, Csilla Kállay, Lajos Nagy, Katalin Várnagy, Imre Sóvágó
Dátum:	2014
ISSN:	0949-8257
Tárgyszavak:	Természettudományok Kémiai tudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Journal of Biological Inorganic Chemistry. - 19 : Suppl 2 (2014), p. S813. -
További szerzők:	Kállay Csilla (1978-) (vegyész) Nagy Lajos (1979-) (vegyész) Várnagy Katalin (1961-) (vegyész) Sóvágó Imre (1946-) (vegyész)
Pályázati támogatás:	TÁMOP 4.2.4.A/2-11-1-2012-0001 TÁMOP
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001-es BibID:	BIBFORM106923
035-os BibID:	(Wos)000734253500001 (Scopus)85121990266
Első szerző:	Cukierman, Daphne Schneider
Cím:	Full Equilibrium Picture in Aqueous Binary and Ternary Systems Involving Copper(II), 1-Methylimidazole-Containing Hydrazonic Ligands, and the 103-112 Human Prion Protein Fragment / Daphne S. Cukierman, Nikolett Bodnár, Renata Diniz, Lajos Nagy, Csilla Kállay, Nicolás A. Rey
Dátum:	2021
ISSN:	0020-1669 1520-510X
Megjegyzések:	In this work, we describe two novel 1-methylimidazole N-acylhydyrazonic ligands and their interaction with copper(II) in solution. Binary systems constituted by each of these hydrazones and the metal ion were studied by potentiometric titrations. The magnitude of their affinities for zinc(II) was also determined for the sake of comparison. Additionally, a full evaluation of the copper(II) chelation profile of the new ligands in ternary systems containing a human prion protein fragment was performed. Mixed ligand complexes comprising the HuPrP103?112 fragment, copper(II) ions, and an N-acylhydrazone were characterized by potentiometry, ultraviolet?visible spectroscopy, and circular dichroism. Some of these species were also identified by electrospray ionization mass spectrometry and unequivocally assigned through their isotopic distribution pattern. To the best of our knowledge, this is the first report concerning the stability of ternary complexes involving a hydrazonic metal?protein interaction modulator, copper, and a peptide. The ability of N-acylhydrazones to prevent peptide oxidation was also examined. Both ligands can partially prevent the formation of the doubly oxidized product, a process mediated by copper(II) ions. Oxidative stress is considered an important hallmark of neurodegenerative diseases such as prion-related spongiform encephalopathies. In this context, active intervention with respect to the deleterious copper-catalyzed methionine oxidation could represent an interesting therapeutic approach.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk
Megjelenés:	Inorganic Chemistry. - 61 : 1 (2021), p. 723-737. -
További szerzők:	Bodnár Nikolett (1994-) (vegyész) Diniz, Renata Nagy Lajos (1979-) (vegyész) Kállay Csilla (1978-) (vegyész) Rey, Nicolas Adrian
Pályázati támogatás:	NKFI-115480 OTKA NKFI-128783 OTKA
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001-es BibID:	BIBFORM103444
035-os BibID:	(Wos)000501026900008 (Scopus)85070294803
Első szerző:	Cukierman, Daphne Schneider
Cím:	Impact of pyridine-2-carboxaldehyde-derived aroylhydrazones on the copper-catalyzed oxidation of the M112A PrP103-112 mutant fragment / Daphne S. Cukierman, Nikolett Bodnár, Beatriz N. Evangelista, Lajos Nagy, Csilla Kállay, Nicolás A. Rey
Dátum:	2019
ISSN:	0949-8257
Megjegyzések:	Misfolded prion protein (PrPSc) is known for its role in fatal neurodegenerative conditions, such as Creutzfeldt-Jakob disease. PrP fragments and their mutants represent important tools in the investigation of the neurotoxic mechanisms and in the evaluation of new compounds that can interfere with the processes involved in neuronal death. Metal-catalyzed oxidation of PrP has been implicated as a trigger for the conformational changes in protein structure, which, in turn, lead to misfolding. Targeting redox-active biometals copper and iron is relevant in the context of protection against the oxidation of biomolecules and the generation of oxidative stress, observed in several conditions and considered an event that might promote sporadic prion diseases as well as other neurodegenerative disorders. In this context, ortho-pyridine aroylhydrazones are of interest, as they can act as moderate tridentate ligands towards divalent metal ions such as copper(II). In the present work, we explore the potentiality of this chemical class as peptide protecting agents against the deleterious metal-catalyzed oxidation in the M112A mutant fragment of human PrP, which mimics relevant structural features that may play an important role in the neurotoxicity observed in prion pathologies. The compounds inhere studied, especially HPCFur, showed an improved stability in aqueous solution compared to our patented lead hydrazone INHHQ, displaying a very interesting protective effect toward the oxidation of methionine and histidine, processes that are related to both physiological and pathological aging.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Aroylhydrazones Human prion protein Copper(II) Methionine oxidation Oxidative stress
Megjelenés:	Journal Of Biological Inorganic Chemistry. - 24 : 8 (2019), p. 1231-1244. -
További szerzők:	Evangelista, Beatriz N. Rey, Nicolas Adrian Kállay Csilla (1978-) (vegyész) Bodnár Nikolett (1994-) (vegyész) Nagy Lajos (1979-) (vegyész)
Pályázati támogatás:	NKFI-115480 Egyéb NKFI-128783 Egyéb GINOP-2.3.2-15-2016-00008 GINOP UNKP-18-4 Egyéb
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001-es BibID:	BIBFORM112815
035-os BibID:	(WoS)001025780100001 (Scopus)85165479537
Első szerző:	Váradi Balázs (vegyész)
Cím:	Synthesis and characterization of a novel [52Mn]Mn-labelled affibody based radiotracer for HER2+ targeting / Balázs Váradi, Károly Brezovcsik, Zoltán Garda, Eniko Madarasi, Horea Szedlacsek, Rodica-Aura Badea, Andrei-Mihai Vasilescu, Adina-Gabriela Puiu, Aura Ionescu, Livia-Elena Sima, Cristian V. A. Munteanu, Simona Cǎlǎraş, Adrienn Vagner, Dezső Szikra, Ngô Minh Toàn, Tibor Nagy, Zoltán Szűcs, Stefan Eugen Szedlacsek, Gabor Nagy, Gyula Tircsó
Dátum:	2023
ISSN:	2052-1545 2052-1553
Megjegyzések:	Targeted molecular imaging is a valuable tool in cancer diagnosis. The palette of manganese isotopes provides an excellent opportunity for bimodal imaging, given that it possesses a long-lived positron-emitting isotope usable in functional Positron Emission Tomography (PET) imaging (52Mn), while the paramagnetic nature of 55Mn makes monoaquated complexes of Mn(II) suitable for magnetic Resonance Imaging (MRI). The present study aims to synthesize new model bifunctional Mn(II) chelators (BFC) derived from the macrocyclic 3,9-PC2A ligand and to test their physicochemical properties. From these 3,9-PC2ABnpCO2H platform was selected for bioconjugation and for further in vivo studies. Anti-HER2 affibody was used as a highly specific binding protein. It was expressed in a prokaryotic system, purified by affinity chromatography followed by RP-HPLC. The specificity of the affibody for HER2 receptors was proved following its conjugation with AlexaFluor555 dye. Finally the affibody was conjugated with the selected 3,9-PC2ABnpCO2H BFC and [52Mn]Mn(II) labelling was performed. The labelled conjugate was tested in vivo by PET imaging using MDA-MB (HER2+) and 4T1 (HER2-) tumour-bearing mice. The results demonstrate that the [[52Mn]Mn(3,9 PC2ABnpMA)(H2O)]-Cys-HER2-affibody conjugate is an efficient and specific molecular vehicle for targeting and visualizing HER2+ tumours by 52Mn-based PET imaging.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Inorganic Chemistry Frontiers. - 10 : 16 (2023), p. 4734-4745. -
További szerzők:	Brezovcsik Károly (1990-) (vegyész) Garda Zoltán (1989-) (vegyész) Madarasi Enikő Szedlacsek, Horea Badea, Rodica-Aura Vasilescu, Andrei-Mihai Puiu, Adina-Gabriela Ionescu, Aura Elena Sima, Livia-Elena Munteanu, Cristian V. A. Cǎlǎraş, Simona Vágner Adrienn (1990-) (vegyész, kémikus) Szikra Dezső Péter (1983-) (vegyész) Toàn, Ngô Minh Nagy Tibor (1988-) (vegyész) Szűcs Zoltán Szedlacsek, Stefan Eugen Nagy Gábor (1990-) (radiokémikus, vegyész) Tircsó Gyula (1977-) (vegyész, kémia tanár)
Pályázati támogatás:	NKFIH-K-128201 Egyéb NKFIH-134694 Egyéb Doctoral School of Chemistry at the University of Debrecen Egyéb Gedeon Richter's Talentum Foundation established by Gedeon Richter Plc (Gedeon Richter Ph.D. Fellowship) Egyéb Doctoral Student Scholarship Program of the Cooperative Doctoral Program of the Ministry of Innovation and Technology financed by the National Research, Development, and Innovation Fund (NKFIH) Egyéb TKP2021-NKTA-42 Egyéb Romanian Ministry of Education and Research, CCDI - UEFISCDI, project number: PN-III-P2-2.1-PED-2019-4184, within PNCDI III, acronym NARAD; PN-III-P1-1.2-PCCDI-2017-0737, within PNCDI III, acronym ARTEMIS; PN-III-P1-1.2-PCCDI-2017-0769, within PNCDI III, acronym ONCORAD Egyéb The Romanian Academy and the Hungarian Academy of Sciences through the bilateral collaboration agreement no. 3698 of 13.09.2018 "Mobility projects" Egyéb
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