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001-es BibID:	BIBFORM003002
Első szerző:	Baranyai Zsolt (vegyész)
Cím:	The effects of intramolecular H-bond formation on the stability constant and water exchange rate of the Gd(III)-diethylenetriamine-N'-(3-amino-1,1-propylenephosphonic)-N,N,N'',N''-tetraacetate complex / Zsolt Baranyai, Eliana Gianolio, Kondareddiar Ramalingam, Rolf Swenson, Ramachandran Ranganathan, E. Brücher, Silvio Aime
Dátum:	2007
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Contrast Media & Molecular Imaging. - 2 : 2 (2007), p. 94-102. -
További szerzők:	Gianolio, Eliana Ramalingam, Kondareddiar Swenson, Rolf Ranganathan, Ramachandran Brücher Ernő (1935-) (vegyész) Aime, Silvio
Internet cím:	elektronikus változat elektronikus változat
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001-es BibID:	BIBFORM067463
Első szerző:	Geninatti-Crich, Simonetta
Cím:	Mn-loaded apoferritin: a highly sensitive MRI imaging probe for the detection and characterization of hepatocarcinoma lesions in a transgenic mouse model / Simonetta Geninatti Crich, Juan Carlos Cutrin, Stefania Lanzardo, Laura Conti, Ferenc K. Kálmán, Ibolya Szabó, Néstor R. Lago, Achille Iolascon, Silvio Aime
Dátum:	2012
ISSN:	1555-4309 1555-4317
Megjegyzések:	Mn-Apo is a highly sensitive MRI contrast agent consisting of ca. 1000 manganese atoms entrapped in the inner cavity of apoferritin. Part of the metallic payload is in the form of Mn2+ ions that endow the nano-sized system with a very high relaxivity that can be exploited to detect hepatocellular carcinoma in mice. Cellular studies showed that Mn-Apo is readily taken up by normal hepatocytes via the ferritin transporting route. Conversely, hepatoma cells (HTC) displayed a markedly reduced ability to entrap Mn-Apo from the culture medium. The i.v. administration of Mn-Apo into C57BL/6?J mice resulted in a marked liver tissue hyperintensity in T1-weighted MR image?20?min after injection. When injected into HBV-tg transgenic mice that spontaneously develop hepatocellular carcinoma (HCC), Mn-Apo allowed a clear delineation of healthy liver tissue and tumor lesions as hyperintense and hypointense T1-weighted MR images, respectively. Immunohistochemistry analysis correlated Mn-Apo cellular uptake to SCARA5 receptor expression. When the MRI contrast induced by Mn-Apo was compared with that induced by Gd?BOPTA (a commercial contrast agent known to enter mouse hepatocytes through organic anion transporters) it was found that only some of the lesions were detected by both agents while others could only be visualized by one of the two. These results suggest that Mn-Apo may be useful to detect otherwise invisible lesions and that the extent of its uptake directly reports the expression/regulation of SCARA5 receptors. Mn-Apo contrast-enhanced MR images may therefore contribute to improving HCC lesion detection and characterization.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk hepatocellular carcinoma MRI ferritin molecular imaging manganese
Megjelenés:	Contrast Media and Molecular Imaging. - 7 : 3 (2012), p. 281-288. -
További szerzők:	Cutrin, Juan Carlos (vegyész) Lanzardo, Stefania (vegyész) Kálmán Ferenc K. (1978-) (vegyész) Kálmán-Szabó Ibolya (1980-) (molekuláris biológus) Lago, Néstor R. (Biológus) Iolascon, Achille Aime, Silvio
Pályázati támogatás:	PD-OTKA-83253 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM010526
Első szerző:	Mani, Tomoyasu
Cím:	Modulation of water exchange in Eu(III) DOTA-tetraamide complexes : considerations for in vivo imaging of PARACEST agents / Tomoyasu Mani, Gyula Tircsó, Osamu Togao, Piyu Zhao, Todd C. Soesbe, Masaya Takahashi, A. Dean Sherry
Dátum:	2009
ISSN:	1555-4309
Megjegyzések:	Modulation of water exchange in lanthanide(III)-DOTA type complexes has drawn considerable attention over the past two decades, particularly because of their application as contrast agents for magnetic resonance imaging. LnDOTA-tetraamide complexes display unusually slow water exchange kinetics and this chemical property offers an opportunity to use these complexes as a new type of contrast agent based upon the chemical exchange saturation transfer (CEST) mechanism. Six new DOTA-tetraamide ligands having side-chain amide arms with varying hydrophobicity and polarity were prepared and the water exchange characteristic of complexes formed with europium(III) complexes were investigated. The results show that introduction of steric bulk into the amide side-chain arms of the europium(III) complexes not only favors formation of the mono-capped twisted square antiprism coordination isomers, the isomer that is generally less favourable for CEST, but also accelerates water exchange in the mono-capped square antiprism isomers. However, converting single methyl groups on these bulky arms to carboxyl or carboxyl ethyl esters results in a rather dramatic decrease in water exchange rates, about 50-fold. Thus, steric bulk, polarity and hydrophobicity of the amide side-chains each contribute to organization of water molecules in the second hydration sphere of the europium(III) ion and this in turn controls water exchange in these complexes. Copyright (C) 2009 John Wiley & Sons, Ltd.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Contrast Media & Molecular Imaging. - 4 : 4 (2009), p. 183-191. -
További szerzők:	Tircsó Gyula (1977-) (vegyész, kémia tanár) Togao, Osamu Zhao, Piyu Soesbe, Todd C. Takahashi, Masaya Sherry, A. Dean
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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