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001-es BibID:	BIBFORM006191
Első szerző:	Farkas Etelka (vegyész)
Cím:	Effects of imidazole containing Rc substituents on the metal binding capability of potentially metalloenzyme inhibitor hydroxamic acids / Etelka Farkas, Edit Csapó, Péter Buglyó
Dátum:	2008
ISSN:	1257-2535
Megjegyzések:	The role of R-C substituents, involving imidazole moiety, in complexation of various potentially metalloenzyme inhibitor hydroxamic acids, R-C-CO-N(R-N)-OH, (derivatives of amino acids and small peptides) with Cu(II), Ni(II) and Zn(II) ions has been investigated using pH-potentiometry and different spectroscopic methods. Many factors were found to affect the competition of the imidazole with the hydroxamate moiety for the metal ions, e.g. the distance between these two functions, presence/absence of additional donor in the R-C chain, sort of metal ion. The structure effect relation is planned to evaluate in the presentation.N2 - The role of R-C substituents, involving imidazole moiety, in complexation of various potentially metalloenzyme inhibitor hydroxamic acids, R-C-CO-N(R-N)-OH, (derivatives of amino acids and small peptides) with Cu(II), Ni(II) and Zn(II) ions has been investigated using pH-potentiometry and different spectroscopic methods. Many factors were found to affect the competition of the imidazole with the hydroxamate moiety for the metal ions, e.g. the distance between these two functions, presence/absence of additional donor in the R-C chain, sort of metal ion. The structure effect relation is planned to evaluate in the presentation.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban hydroxamic acid imidazole metal complexes metalloenzyme inhibitors Histidyl residues complexes peptides ligands stability
Megjelenés:	Metal ions in biology and medicine. - 10 (2008), p. 393-398. -
További szerzők:	Csapó Edit (1983-) (vegyész) Buglyó Péter (1965-) (vegyész)
Internet cím:	elektronikus változat
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