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001-es BibID:	BIBFORM017952
Első szerző:	Barta Kitti (belgyógyász)
Cím:	The effect of sleep apnea on QT interval, QT dispersion, and arrhythmias / Barta K., Szabó Z., Kun C., Munkácsy C., Bene O., Tünde Magyar M., Csiba L., Lörincz I.
Dátum:	2010
Megjegyzések:	QT interval (QT) and QT dispersion (QTd) are electrocardiograph (ECG) parameters for theevaluation of myocardial repolarization. The inhomogeneity of ventricular repolarization is associatedwith ventricular arrhythmias. An increased QT, QTd, and increased incidence of nocturnal cardiac rhythmdisturbances have been described in patients with obstructive sleep apnea (OSA), while other investigatorsdid not find a relationship between ventricular arrhythmias and OSA.Hypothesis: The aim of this study was to examine the occurrence of ventricular arrhythmias and to measureQT parameters in patientswith untreatedOSA using an ambulatory Holter-ECG. Methods: A total of 25 patientswith untreatedOSA were studied. After routine biochemical investigation and2-dimensional, M-mode echocardiography, a 24-hour Holter-ECG was recorded to detect cardiac arrhythmiasand QT parameters. QT parameters were measured by the QT Guard system. Results: Only the QT interval increased significantly during the nighttime period (nocturnal QT interval: 423.1 +/- 34.6 ms, daytime QT interval: 381.6 +/- 33.8 ms, 24-hour QT interval: 394.7 +/- 31.1 ms). However, during the nighttime QT interval (422.8 +/- 14.9 ms), QTd (31.2 +/- 11.0 ms) and QT dispersion (30.5 +/- 10.2 ms) did not show any change compared to 24-hour (QTc interval: 423.7 +/- 14.2 ms, QTd: 28.8 +/- 9.4 ms, QTcd: 30.5 +/- 9.43 ms) and daytime levels (QTc interval: 423.9 +/- 14.3 ms, QTd: 27.3 +/- 10.7 ms, QTcd: 29.9 +/- 11.1 ms). None of the patients had ventricular arrhythmias. Conclusions: QTd and QTcd did not increase during the nighttime period. Our study did not show an increasedrisk of ventricular arrhythmias in this population during the monitoring period.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Clinical Cardiology 33 : 6 (2010), p. E35-E39. -
További szerzők:	Szabó Zoltán (1973-) (belgyógyász, kardiológus) Kun Csaba (1969-) (kardiológus) Munkácsy Csaba Bene Orsolya (1980-) (kardiológus) Magyar Mária Tünde (1970-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Lőrincz István (1950-) (belgyógyász, kardiológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM050495
Első szerző:	Nagy Valéria (szemész)
Cím:	Cardiovascular and thrombophilic risk factors in retinal vein occlusion / Valeria Nagy, Zsuzsa Balogh, Márta Kasza, Bernadett Ujhelyi, Adrienne Csutak, Izabella Reznek, Judit Damjanovich, Andras Berta, György Pfliegler
Dátum:	2014
ISSN:	1205-6626 1918-1515
Megjegyzések:	Retinal Vein Occlusion (RVO) is a retinal disorder resulting in a progressive, severe loss of visual acuity. Its pathogenesis has not yet been clarified. The aim of our study was to investigate cardiovascular and thrombophilic risk factors, and their interaction. 145 RVO patients and 100 control subjects were examined. Protein C, protein S, antithrombin activity, antigen levels, prothrombin G20210A gene polymorphism, factor VIII level, factor V (Leiden) mutation, plasminogen activity, lipoprotein(a), von Willebrand factor, homocysteine and fibrinogen levels and anticardiolipin antibodies were assessed. Possible relevant pathologies (e.g. diabetes mellitus, hypertension and hyperlipidemia) were also registered. Multiple logistic regression analysis revealed that hypertension was a predictive thrombophilic factor in female patients with decreased antithrombin (OR=5.69, 95% CI=2.00-16.14, p=0.0011). Male gender may be a risk factor in patients with normal blood pressure and non-elevated lipoprotein(a) level as well (OR=4.274, 95% CI=1.748-10.448, p=0.0015).Based on our results it appears that thrombophilia is likely to contribute to the development of RVO, especially if associated with cardiovascular risk factors, like hypertension. In case of justified thrombophilia mainly with hypertension, anticoagulant and/or antiplatelet therapy may be advantageous to prevent fellow eye involvement.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban retinal vein occlusion thrombophilia cardiovascular risk factors
Megjelenés:	Experimental & Clinical Cardiology. - 20 : 1 (2014), p. 238-244. -
További szerzők:	Balogh Zsuzsa (1981-) (orvos) Kasza Márta Ujhelyi Bernadett (1981-) (szemész) Csutak Adrienne (1971-) (szemész) Reznek Izabella Damjanovich Judit (1963-) (szemész) Berta András (1955-) (szemész, gyermekszemész) Pfliegler György (1949-) (belgyógyász, hematológus, labor szakorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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