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001-es BibID:BIBFORM114632
035-os BibID:(cikkazonosító)2954 (scopus)85172226742 (wos)001073257100001
Első szerző:Janka Tamás
Cím:The Value of Neutrophil-to-Lymphocyte Ratio to Identify Bacterial Infection and Predict Short-Term Mortality in Patients with Acutely Decompensated Cirrhosis / Tamás Janka, Dávid Tornai, Mária Papp, Zsuzsanna Vitális
Dátum:2023
ISSN:2075-4418
Megjegyzések:Liver cirrhosis patients are highly susceptible to infections, affecting survival, but current param-eters for detecting infection are not reliable enough in this population. We investigated ability of white blood cell (WBC), ?WBC, neutrophil and ?neutrophil count, neutrophil-to-lymphocyte (NLR) and ?NLR ratio, CRP, and PCT to identify infection and predict short-term mortality in liver cir-rhosis patients. We recruited 233 patients with liver cirrhosis hospitalized with acute decompen-sation (AD) who had an outpatient visit within 1 month (baseline laboratory data) and followed them for 90 days. Difference between laboratory values at baseline and the AD episode was defined as delta (?) values of the parameters. Delta values did not increase the diagnostic and predictive ability of investigated parameters. CRP was found to be the best diagnostic marker for infection in patients with cirrhosis. However, NLR seems to be superior for short-term mortality prediction, better than WBC. Distinguishing inflammations of different origin is a remaining clinical challenge in acutely decompensated cirrhosis. Based on our results NLR might be more suitable for predicting short-term mortality in patients with AD than WBC count currently included in CLIF-C AD score.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Diagnostics. - 13 : 18 (2023), p. 1-14. -
További szerzők:Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus)
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2.

001-es BibID:BIBFORM106266
035-os BibID:(cikkazonosító)14 (Scopus)85145924688 (WoS)000908868000001
Első szerző:Módis László V. (neurológus)
Cím:Central Nervous System Involvement in Primary Sjögren's Syndrome : Narrative Review of MRI Findings / Módis László V., Aradi Zsófia, Horváth Ildikó Fanny, Bencze János, Papp Tamás, Emri Miklós, Berényi Ervin, Bugán Antal, Szántó Antónia
Dátum:2023
ISSN:2075-4418
Megjegyzések:Central nervous system (CNS) involvement is one of the numerous extraglandular manifestations of primary Sjögren's syndrome (pSS). Moreover, neurological complaints precede the sicca symptoms in 25-60% of the cases. We review the magnetic resonance imaging (MRI) lesions typical for pSS, involving the conventional examination, volumetric and morphometric studies, diffusion tensor imaging (DTI) and resting-state fMRI. The most common radiological lesions in pSS are white matter hyperintensities (WMH), scattered alterations hyperlucent on T2 and FLAIR sequences, typically located periventricularly and subcortically. Cortical atrophy and ventricular dilatation can also occur in pSS. Whilst these conditions are thought to be more common in pSS than healthy controls, DTI and resting-state fMRI alterations demonstrate evident microstructural changes in pSS. As pSS is often accompanied by cognitive symptoms, these MRI alterations are expectedly related to them. This relationship is not clearly delineated in conventional MRI studies, but DTI and resting-state fMRI examinations show more convincing correlations. In conclusion, the CNS manifestations of pSS do not follow a certain pattern. As the link between the MRI lesions and clinical manifestations is not well established, more studies involving larger populations should be performed to elucidate the correlations.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Sjögren's syndrome
central nervous system
magnetic resonance imaging
white matter hyperintensities
Megjelenés:Diagnostics. - 13 : 1 (2023), p. 1-18. -
További szerzők:Aradi Zsófia (1992-) (belgyógyász szakorvos) Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus) Bencze János (1991-) (orvos) Papp Tamás (1987-) (orvos) Emri Miklós (1962-) (fizikus) Berényi Ervin (1964-) (radiológus) Bugán Antal (1948-) (pszichológus, klinikai szakpszichológus, pszichoterapeuta) Szántó Antónia (1977-) (belgyógyász, allergológus és klinikai immunológus)
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3.

001-es BibID:BIBFORM083015
035-os BibID:(WoS)000513129500033 (Scopus)85078461475
Első szerző:Molnár Csaba (pathológus)
Cím:High Genetic Diversity and No Evidence of Clonal Relation in Synchronous Thyroid Carcinomas Associated with Hashimoto's Thyroiditis : a Next-Generation Sequencing Analysis / Molnár Csaba, Bádon Emese Sarolta, Mokánszki Attila, Mónus Anikó, Beke Lívia, Győry Ferenc, Nagy Endre, Méhes Gábor
Dátum:2020
ISSN:2075-4418
Megjegyzések:The close association between pre-existing Hashimoto's thyroiditis and thyroid cancer is well established. The simultaneous occurrence of multiple neoplastic foci within the same organ suggests a common genotoxic effect potentially contributing to carcinogenesis, the nature of which is still not clear. Next-generation sequencing (NGS) provides a potent tool to demonstrate and compare the mutational profile of the independent neoplastic foci. Our collection of 47 cases with thyroid carcinoma and Hashimoto's thyroiditis included 14 with at least two tumorous foci. Detailed histological analysis highlighted differences in histomorphology, immunoprofile, and biological characteristics. Further, a 67-gene NGS panel was applied to demonstrate the mutational diversity of the synchronic tumors. Significant differences could be detected with a wide spectrum of pathogenic gene variants involved (ranging between 5 and 18, cutoff >5.0 variant allele frequencies (VAF)). Identical gene variants represented in both synchronous tumors of the same thyroid gland were found in only two cases (BRAF and JAK3 genes). An additional set of major driver mutations was identified at variable allele frequencies in a highly individual setup suggesting a clear clonal independence. The different BRAF statuses in coincident thyroid carcinoma foci within the same organ outline a special challenge for molecular follow-up and therapeutic decision-making.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Diagnostics. - 10 : 1 (2020), p. 1-11. -
További szerzők:Bádon Emese Sarolta (1991-) (orvos) Mokánszki Attila (1983-) (molekuláris biológus Ph.D hallgató) Mónus Anikó Beke Lívia Győry Ferenc (1969-) (kardiológus) Nagy Endre V. (1957-) (belgyógyász, endokrinológus) Méhes Gábor (1966-) (patológus)
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4.

001-es BibID:BIBFORM114463
035-os BibID:(cikkazonosító)2897 (Scopus)85172253351
Első szerző:Obajed Al-Ali Nóra (okleveles orvosdoktor)
Cím:One step back from bedside to the bench - How do different arterial stiffness parameters behave in relation to peripheral resistance? / Nóra Obajed Al-Ali, Sára Rebeka Tóth, László Váróczy, László Imre Pinczés, Pál Soltész, Zoltán Szekanecz, György Kerekes
Dátum:2023
ISSN:2075-4418
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
arterial stiffness
cardiovascular risk
elasticity parameters
distensibility coefficient
pulse wave velocity
oscillometry
applanation tonometry
Megjelenés:Diagnostics. - 13 (2023), p. 1-14. -
További szerzők:Tóth Sára Váróczy László (1974-) (belgyógyász, haematológus) Pinczés László Imre (1990-) (általános orvos) Soltész Pál (1961-) (belgyógyász, kardiológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Kerekes György (1973-) (belgyógyász, kardiológus, angiológus)
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5.

001-es BibID:BIBFORM108355
035-os BibID:(cikkazonosító)556 (WoS)000933828200001 (Scopus)85147861701
Első szerző:Rákóczi Éva (klinikai szakorvos)
Cím:Evaluation of the Efficacy of BBIBP-CorV Inactivated Vaccine Combined with BNT62b2 mRNA Booster Vaccine / Éva Rákóczi, Gusztáv Magócs, Sára Kovács, Béla Nagy, Gabriella Szűcs, Zoltán Szekanecz
Dátum:2023
ISSN:2075-4418
Megjegyzések:Abstract: Objectives: In this prospective study, SARS-CoV??2 spike protein specific total immunoglobulin (Ig) levels were analyzed before and after BNT162 b2 mRNA booster vaccination in individuals previously administered with two doses of BBIBP-CorV vaccine in comparison to immunized participants with three doses of BNT162 b2 vaccination. Methods: Sixty-one Caucasian volunteers (39 females, 22 males) vaccinated by BBIBP-CorV were included (mean age: 63.9 years). Sixty-one patients (41 females, 20 males) as controls were vaccinated with BNT162b2 (mean age: 59.9 years). Both groups received the third booster BNT162b2 vaccine. Total anti-SARS-CoV??2 S1-RBD Ig levels were measured by an immunoassay (Roche Diagnostics) and their calculated ratios after/before booster dose were compared between the two groups. Results: At baseline, significantly lower anti-SARS-CoV??2 S1-RBD total antibody levels were determined after initial immunization by two doses of inactivated BBIBP-CorV compared to BNT62b2 mRNA vaccine (p < 0.001). After BNT162b2 boosters, similarly high total Ig levels were detected in both the heterologous (27,195 [15,604?42,754] BAU/mL, p < 0.001) and the homologous booster cohort (24,492 [13,779??42,671] BAU/mL, p < 0.001) compared to baseline. Hence, the ratio of after/before total Ig levels was significantly higher with heterologous vs homologous immunization (p < 0.001). Conclusion: To address the concept that basic BBIBP-CorV vaccination is not as effective as BNT162b, we analyzed the effect of heterologous vaccination with BNT162b2. Our results suggest that BNT162b2 can successfully boost the effects of two-dose BBIBP-CorV vaccination.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
COVID-19
BBIBP-CorV
BNT62b2
booster
vaccine
Megjelenés:Diagnostics. - 13 : 3 (2023), p. 1-12. -
További szerzők:Magócs Gusztáv Kovács Sára Nagy Béla Jr. (1980-) (labordiagnosztikai szakorvos) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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6.

001-es BibID:BIBFORM094040
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Rheumatoid arthritis diagnosis with antimutated citrullinated vimentin ELISA by Orgentec Diagnostika / Szekanecz Zoltán, Gabriella Lakos
Dátum:2008
ISSN:1753-0059 1753-0067
Megjegyzések:Background: There is a need for highly sensitive and specific laboratory tests for the early diagnosis of rheumatoid arthritis (RA). Anticitrullinated protein/peptide antibodies are produced in the sera of RA patients. Objective: To assess and discuss the diagnostic value of Orgentec antimutated citrullinated vimentin (anti-MCV) ELISA and to compare this diagnostic to commercially available anticyclic citrullinated peptide (anti-CCP) tests. Methods: The evaluation is based on our recently published study on the comparison of anti-MCV and anti-CCP2 tests, as well as on published studies. Results/conclusion: In established RA, the anti-MCV ELISA exerts a specificity comparable with anti-CCP2. Numerous recent studies suggest that anti-MCV may have higher sensitivity, however there are also some publications stating the opposite. In early RA, anti-MCV may be a better predictor of disease activity and radiological progression than anti-CCP tests.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
anricyclic citrullinared pepride
anrirnutated citrullinared vimenrin
rheumatoid arthritis
Megjelenés:Expert opinion on medical diagnostics. - 2 : 9 (2008), p. 1083-1090. -
További szerzők:Lakos Gabriella (1963-) (laboratóriumi szakorvos, transzfúziológus, immunológus)
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