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001-es BibID:	BIBFORM117710
035-os BibID:	(cikkazonosító)e23682 (WoS)001138350900001 (Scopus)85180289369
Első szerző:	Ramos-Medina, María José
Cím:	CardiOmics signatures reveal therapeutically actionable targets and drugs for cardiovascular diseases / María José Ramos-Medina, Gabriela Echeverría-Garcés, Nikolaos C. Kyriakidis, Ángela León Cáceres, Esteban Ortiz-Prado, Jhommara Bautista, Álvaro A. Pérez-Meza, Andrea Abad-Sojosi, Karol Nieto-Jaramillo, Samantha Espinoza-Ferrao, Belén Ocaña-Paredes, Andrés López-Cortés
Dátum:	2024
ISSN:	2405-8440
Megjegyzések:	Cardiovascular diseases are the leading cause of death worldwide, with heart failure being a complex condition that affects millions of individuals. Single-nucleus RNA sequencing has recently emerged as a powerful tool for unraveling the molecular mechanisms behind cardiovascular diseases. This cutting-edge technology enables the identification of molecular signatures, intracellular networks, and spatial relationships among cardiac cells, including cardiomyocytes, mast cells, lymphocytes, macrophages, lymphatic endothelial cells, endocardial cells, endothelial cells, epicardial cells, adipocytes, fibroblasts, neuronal cells, pericytes, and vascular smooth muscle cells. Despite these advancements, the discovery of essential therapeutic targets and drugs for precision cardiology remains a challenge. To bridge this gap, we conducted comprehensive in silico analyses of single-nucleus RNA sequencing data, functional enrichment, protein interactome network, and identification of the shortest pathways to physiological phenotypes. This integrated multi-omics analysis generated CardiOmics signatures, which allowed us to pinpoint three therapeutically actionable targets (ADRA1A1, PPARG, and ROCK2) and 15 effective drugs, including adrenergic receptor agonists, adrenergic receptor antagonists, norepinephrine precursors, PPAR receptor agonists, and Rho-associated kinase inhibitors, involved in late-stage cardiovascular disease clinical trials.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Heliyon. - 10 : 1 (2024), p. 1-17 . -
További szerzők:	Echeverría-Garcés, Gabriela Kyriakidis, Nikolaos C. León Cáceres, Ángela Ortiz-Prado, Esteban Bautista, Jhommara Pérez-Meza, Álvaro A. Abad-Sojos, Andrea Nieto-Jaramillo, Karol Espinoza-Ferrao, Samantha Ocaña-Paredes, Belén López-Cortés, Andrés
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