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001-es BibID:	BIBFORM095571
035-os BibID:	(WoS)000627328400001 (Scopus)85102438552 (PubMed)33716672 (cikkazonosító)614947
Első szerző:	Bayasgalan, Tsogbadrakh (Általános orvos)
Cím:	Topographical Organization of M-Current on Dorsal and Median Raphe Serotonergic Neurons / Tsogbadrakh Bayasgalan, Andrea Csemer, Adrienn Kovacs, Krisztina Pocsai, Balazs Pal
Dátum:	2021
ISSN:	1662-5102
Megjegyzések:	Dorsal and median raphe nuclei (DR and MR, respectively) are members of the reticular activating system and play important role in the regulation of the sleepwakefulness cycle, movement, and affective states. M-current is a voltage-gated potassium current under the control of neuromodulatory mechanisms setting neuronal excitability. Our goal was to determine the proportion of DR and MR serotonergic neurons possessing M-current and whether they are organized topographically. Electrophysiological parameters of raphe serotonergic neurons influenced by this current were also investigated. We performed slice electrophysiology on genetically identified serotonergic neurons. Neurons with M-current are located rostrally in the DR and dorsally in the MR. M-current determines firing rate, afterhyperpolarization amplitude, and adaptation index (AI) of these neurons, but does not affect input resistance, action potential width, and high threshold oscillations.These findings indicate that M-current has a strong impact on firing properties of certain serotonergic neuronal subpopulations and it might serve as an effective contributor to cholinergic and local serotonergic neuromodulatory actions.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Cellular Neuroscience. - 15 (2021), p. 614947. -
További szerzők:	Csemer Andrea (1994-) (molekuláris biológus) Kovács Adrienn (1989-) (molekuláris biológus) Pocsai Krisztina (1978-) (élettanász) Pál Balázs (1975-) (élettanász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM095575
035-os BibID:	(cikkazonosító)707789 (WoS)000683012200001 (Scopus)85112145519 (PubMed)34381336
Első szerző:	Bayasgalan, Tsogbadrakh (Általános orvos)
Cím:	Alteration of mesopontine cholinergic function by the lack of KCNQ4 subunit / Bayasgalan T., Stupniki S., Kovács A., Csemer A., Szentesi P., Pocsai K., Dionisio L., Spitzmaul G., Pál B.
Dátum:	2021
ISSN:	1662-5102
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Cellular Neuroscience. - 15 (2021), p. 707789. -
További szerzők:	Stupniki, S. Kovács Adrienn (1989-) (molekuláris biológus) Csemer Andrea (1994-) (molekuláris biológus) Szentesi Péter (1967-) (élettanász) Pocsai Krisztina (1978-) (élettanász) Dionisio, L. Spitzmaul, G. Pál Balázs (1975-) (élettanász)
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001-es BibID:	BIBFORM060223
Első szerző:	Bordás Csilla
Cím:	The M-current contributes to high threshold membrane potential oscillations in a cell type-specific way in the pedunculopontine nucleus of mice / Bordas Csilla, Kovacs Adrienn, Pal Balazs
Dátum:	2015
ISSN:	1662-5102
Megjegyzések:	The pedunculopontine nucleus is known as a cholinergic nucleus of the reticular activating system, participating in regulation of sleep and wakefulness. Besides cholinergic neurons, it consists of GABAergic and glutamatergic neurons as well. According to classical and recent studies, more subgroups of neurons were defined. Groups based on the neurotransmitter released by a neuron are not homogenous, but can be further subdivided. The PPN neurons do not only provide cholinergic and non-cholinergic inputs to several subcortical brain areas but they are also targets of cholinergic and other different neuromodulatory actions. Although cholinergic neuromodulation has been already investigated in the nucleus, one of its characteristic targets, the M-type potassium current has not been described yet. Using slice electrophysiology, we provide evidence in the present work that cholinergic neurons possess M-current, whereas GABAergic neurons lack it. The M-current contributes to certain functional differences of cholinergic and GABAergic neurons, as spike frequency adaptation, action potential firing frequency or the amplitude difference of medium afterhyperpolarizations (AHPs). Furthermore, we showed that high threshold membrane potential oscillation with high power, around 20 Hz frequency is a functional property of almost all cholinergic cells, whereas GABAergic neurons have only low amplitude oscillations. Blockade of the M-current abolished the oscillatory activity at 20 Hz, and largely diminished it at other frequencies. Taken together, the M-current seems to be characteristic for PPN cholinergic neurons. It provides a possibility for modulating gamma band activity of these cells, thus contributing to neuromodulatory regulation of the reticular activating system.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban M-current Neuromodulation oscillatory activity pedunculopontine nucleus spike frequency adaptation
Megjelenés:	Frontiers in Cellular Neuroscience. - 9 (2015), Article ID 121. -
További szerzők:	Kovács Adrienn (1989-) (molekuláris biológus) Pál Balázs (1975-) (élettanász)
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001-es BibID:	BIBFORM071275
Első szerző:	Szilasi Magdolna Emma (pulmonológus)
Cím:	The alteration of irisin - brain-derived neurotrophic factor axis parallels severity of distress disorder in bronchial asthma patients / Magdolna Emma Szilasi, Krisztian Pak, Laszlo Kardos, Viktoria Evelin Varga, Ildiko Seres, Angela Mikaczo, Andrea Fodor, Maria Szilasi, Gabor Tajti, Csaba Papp, Rudolf Gesztelyi, Judit Zsuga
Dátum:	2017
ISSN:	1662-453X
Megjegyzések:	Distress disorder (a collective term for generalized anxiety disorder and major depressive disorder) is a well-known co-morbidity of bronchial asthma. The irisin - brain-derived neurotrophic factor (BDNF) axis is a pathway that influences several neurobehavioral mechanisms involved in the pathogenesis of distress disorder. Thus, the aim of the present study was to quantify the serum irisin and BDNF concentrations in order to investigate the possible link between the irisin/BDNF axis and distress disorder in an asthma patient cohort.Data of 167 therapy-controlled asthma patients were analyzed. Demographic, anthropometric and anamnestic data were collected, routine laboratory parameters supplemented with serum irisin and BDNF levels were determined, pulmonary function test was performed using whole-body plethysmography, and quality of life was quantified by means of the St. George's Respiratory Questionnaire (SGRQ). Correlation analysis as well as simple and multiple linear regression were used to assess the relationship between the irisin level and the Impacts score of SGRQ, which latter is indicative of the presence and severity of distress disorder.We have found a significant, positive linear relationship between the Impacts score and the reciprocal of irisin level. This association was stronger in patients whose BDNF level was higher, and it was weaker (and statistically non-significant) in patients whose BDNF level was lower. Our results indicate that higher serum irisin level together with higher serum BDNF level are associated with milder (or no) distress disorder. This finding suggests that alteration of the irisin/BDNF axis influences the presence and severity of distress disorder in asthma patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban irisin BDNF distress disorder bronchial asthma SGRQ whole-body plethysmography
Megjelenés:	Frontiers in Neuroscience. - 11 (2017), p. 1-12. -
További szerzők:	Pák Krisztián (1987-) (gyógyszerész) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Varga Viktória Evelin (1988-) (biológus) Seres Ildikó (1954-) (biokémikus) Mikáczó Angéla (1980-) (tüdőgyógyász) Fodor Andrea (1964) (tüdőgyógyász) Szilasi Mária (1953-) (tüdőgyógyász, klinikai immunológus, allergológus, belgyógyász) Tajti Gábor (1988-) (gyógyszerész, biofizikus, sejtbiológus) Papp Csaba (1966-) (aneszteziológus és intenzív terápiás szakorvos) Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Zsuga Judit (1973-) (neurológus, pszichoterapeuta, egészségügyi szakmanager)
Pályázati támogatás:	KTIA_13_NAP-A-V/2 Egyéb
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