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001-es BibID:	BIBFORM100404
035-os BibID:	(cikkazonosító)784220
Első szerző:	Kőszegi Zsolt (kardiológus, belgyógyász)
Cím:	Anatomical Assessment vs. Pullback REsting full-cycle rAtio (RFR) Measurement for Evaluation of Focal and Diffuse CoronarY Disease : rationale and Design of the "READY Register" / Kőszegi Zsolt, Berta Balázs, Tóth Gábor G., Tar Balázs, Üveges Áron, Ágoston András, Szücs Attila, Szabó Gábor Tamás, Barta Judit, Szük Tibor, Czuriga Dániel, Komócsi András, Ruzsa Zoltán
Dátum:	2021
ISSN:	2297-055X 2297-055X
Megjegyzések:	Background: The morphology and functional severity of coronary stenosis show poor correlation. However, in clinical practice, the visual assessment of the invasive coronary angiography is still the most common means for evaluating coronary disease. The fractional flow reserve (FFR), the coronary flow reserve (CFR), and the resting full-cycle ratio (RFR) are established indices to determine the hemodynamic significance of a coronary stenosis. Design/Methods: The READY register (NCT04857762) is a prospective, multicentre register of patients who underwent invasive intracoronary FFR and RFR measurement. The main aim of the registry is to compare the visual estimate of coronary lesions and the functional severity of the stenosis assessed by FFR, as well as the RFR pullback. Characterizations of the coronary vessel for predominantly focal, diffuse, or mixed type disease according to visual vs. RFR pullback determination will be compared. The secondary endpoint of the study is a composite of major adverse cardiac events, including death, myocardial infarction, and repeat coronary revascularization at 1 year. These endpoints will be compared in patients with non-ischemic FFR in the subgroup of cases where the local pressure drop indicates a focal lesion according to the definition of ?RFR > 0.05 (for <25 mm segment length) and in the subgroup without significant ?RFR. In case of an FFR value above 0.80, an extended physiological analysis is planned to diagnose or exclude microvascular disease using the CFR/FFR index. This includes novel flow dynamic modeling for CFR calculation (CFRp-3D). Conclusion: The READY register will define the effect of RFR measurement on visual estimation-based clinical decision-making. It can identify a prognostic value of ?RFR during RFR pullback, and it would also explore the frequency of microvascular disease in the patient population with FFR > 0.80. Clinical Trial Registration: ClinicalTrials.gov (NCT04857762).
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk resting full-cycle ratio (RFR) microvascular coronary disease fractional flow reserve (FFR) coronary flow reserve (CFR) coronary artery disease
Megjelenés:	Frontiers in Cardiovascular Medicine. - 8 (2021), p. 1-7. -
További szerzők:	Berta Balázs Tóth Gábor G. Tar Balázs (1970-) (orvos) Üveges Áron Ágoston András Szücs Attila Szabó Gábor Tamás (1982-) (kardiológus) Barta Judit (1975-) (kardiológus) Szűk Tibor (1967-) (kardiológus) Czuriga Dániel (1982-) (kardiológus) Komócsi András Ruzsa Zoltán
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001-es BibID:	BIBFORM117090
035-os BibID:	(cikkazonosító)1270093 (WoS)001116444000001 (Scopus)85179329820
Első szerző:	Pituk Dóra
Cím:	The association between EPCR gene p.Ser219Gly polymorphism and venous thromboembolism risk : a case-control study, meta-analysis, and a reproducibility study / Pituk Dóra, Miklós Tünde, Schlammadinger Ágota, Rázsó Katalin, Bereczky Zsuzsanna
Dátum:	2023
ISSN:	2297-055X
Megjegyzések:	Background: The rs867186 single-nucleotide polymorphism in the PROCR gene (g.6936A > G, c.4600A > G) results in a serine-to-glycine substitution at codon 219 of endothelial protein C receptor (EPCR). We performed a case-control study followed by an updated meta-analysis of the association between this polymorphism and the risk of venous thromboembolism (VTE).Objective and methods: We enrolled 263 VTE patients and 320 unrelated healthy controls for the case-control study. The total number of cases and controls for the meta-analysis were 5,768 and 30,017, respectively. A new online MetaGenyo Statistical Analysis System software was used to perform the current meta-analysis. Furthermore, a reproducibility study was conducted to validate our results.Results: Among well-defined thrombosis risk factors, Factor V Leiden was more frequent in the VTE group (p < 0.001), while there was no difference in mutation frequency of prothrombin 20210G>A polymorphism between the two groups. There was no difference in the mutation frequency of Factor V Leiden and prothrombin 20210G>A between cases with and without provoking factors and cases with and without VTE recurrence. The rs867186 "G" carriership did not influence the risk of VTE [odds ratio (OR) 1.339; 95% confidence interval (CI): 0.904-1.984] in our study. No significant differences could be demonstrated among the rs867186 genotype frequencies between VTE cases with and without provoking factors (p = 0.430). PROCR rs867186 was associated with an OR of 1.72 (95% CI: 0.95-3.13, p = 0.075) in terms of VTE recurrence. In the meta-analysis, a significant association was found between EPCR Ser219Gly polymorphism and VTE under the dominant model (OR = 1.27, 95% CI: 1.11-1.46, p = 0.0006), the recessive model (OR = 1.60, 95% CI: 1.26-2.04, p = 0.0001), the GG vs. AA contrast model (OR = 1.64, 95% CI: 1.28-2.09, p = 0.0001), and the GA vs. AA contrast model (OR = 1.24, 95% CI: 1.08-1.43, p = 0.002).Conclusion: The rs867186 was not associated with the first VTE risk in our case-control study; however, a tendency to VTE recurrence was observed. Based on the results of our reproducibility study, MetaGenyo is acceptable for meta-analysis in case of genetic epidemiology studies. Although the risk conferred by the rs867186 is mild in all meta-analyses, including ours, identifying patients carrying the minor allele might have an impact on personalized VTE risk assessment, risk-score calculation, and patient management.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Cardiovascular Medicine. - 10 (2023), p. 1-14. -
További szerzők:	Miklós Tünde Schlammadinger Ágota (1971-) (belgyógyász, haematológus) Molnárné Rázsó Katalin (1966-) (belgyógyász, haematológus, klinikai onkológus) Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos)
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001-es BibID:	BIBFORM103252
035-os BibID:	(cikkazonosító)901286 (WoS)000886464200001 (Scopus)85135188784
Első szerző:	Székely Edina Gabriella
Cím:	Low [alfa]2-Plasmin Inhibitor Antigen Levels on Admission Are Associated With More Severe Stroke and Unfavorable Outcomes in Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis / Székely Edina Gabriella, Orbán-Kálmándi Rita, Szegedi István, Katona Éva, Baráth Barbara, Czuriga-Kovács Katalin Réka, Lóczi Linda, Vasas Nikolett, Fekete István, Fekete Klára, Berényi Ervin, Oláh László, Csiba László, Bagoly Zsuzsa
Dátum:	2022
ISSN:	2297-055X
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Cardiovascular Medicine. - 9 (2022), p. 1-14. -
További szerzők:	Orbán-Kálmándi Rita Angéla (1993-) (klinikai laboratóriumi kutató) Szegedi István (1969-) (hematológus, onkológus, nefrológus) Katona Éva (1961-) (klinikai biokémikus) Baráth Barbara (1991-) (orvosírnok) Czuriga-Kovács Katalin Réka (1981-) (neurológus) Lóczi Linda Molnárné Vasas Nikolett (1987-) (élettanász) Fekete István (1951-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Berényi Ervin (1964-) (radiológus) Oláh László (1967-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Bagoly Zsuzsa (1978-) (orvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00043 GINOP K120042 OTKA FK128582 OTKA K120633 OTKA UNKP-21-4-1 Egyéb
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