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001-es BibID:	BIBFORM069451
035-os BibID:	(WOS)000427432400020 (Scopus)85019612221
Első szerző:	Kárai Bettina (orvos)
Cím:	Expression of Coagulation Factor XIII Subunit A Correlates with Outcome in Childhood Acute Lymphoblastic Leukemia / Bettina Kárai, Zsuzsanna Hevessy, Eszter Szánthó, László Csáthy, Anikó Ujfalusi, Katalin Gyurina, István Szegedi, János Kappelmayer, Csongor Kiss
Dátum:	2018
ISSN:	1219-4956 1532-2807
Megjegyzések:	Abstract Previously we identified B-cell lineage leukemic lymphoblasts as a new expression site for subunit A of blood coagulation factor XIII (FXIII-A). On the basis of FXIII-A expression, various subgroups of B-cell precursor acute lymphoblasticleukemia (BCP-ALL) can be identified. Fifty-five children with BCP-ALL were included in the study. Bone marrow samples were obtained by aspiration and the presenceof FXIII-A was detected by flow cytometry. G-banding and fluorescent in situ hybridization was performed according to standard procedures. The 10-year event-free survival (EFS)and overall survival (OS) rate of FXIII-A-positive and FXIII-A-negative patients showed significant differences (EFS: 84% vs. 61%, respectively; p = 0.031; OS: 89% vs.61%; p = 0.008). Of all the parameters examined, there was correlation only between FXIII-A expression and ♭B-other' genetic subgroup. Further multivariate Cox regression analysis of FXIII-subtype and genetic group or ♭B-other' subgroup identified the FXIII-A negative characteristic as an independent factor associated with poor outcome in BCP-ALL. We found an excellent correlation between long-term survival and the FXIII-A-positive phenotype of BCP lymphoblasts at presentation. The results presented seem to be convincing enough to suggest a possible role for FXIII-A expression in the prognostic grouping of childhood BCP-ALL patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Precursor B-cell acute lymphoblastic leukemia Immunophenotype Factor XIII-A B-other' ALL
Megjelenés:	Pathology and Oncology Research. - 24 : 2 (2018), p. 345-352. -
További szerzők:	Hevessy Zsuzsanna (1966-) (laboratóriumi szakorvos) Szánthó Eszter (laboratóriumi szakorvos jelölt) Csáthy László (1979-) (laboratóriumi szakorvos) Ujfalusi Anikó (1968-) (gyermekorvos, laboratóriumi szakorvos) Gyurina Katalin (1986-) (tudományos segédmunkatárs) Szegedi István (1969-) (hematológus, onkológus, nefrológus) Kappelmayer János (1960-) (laboratóriumi szakorvos) Kiss Csongor (1956-) (hematológus, onkológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM061085
035-os BibID:	(WoS)000366646400030 (Scopus)84951573719
Első szerző:	Ujj Zsófia
Cím:	WT1 Expression in Adult Acute Myeloid Leukemia : assessing its Presence, Magnitude and Temporal Changes as Prognostic Factors / Zsófia Ujj, Gergely Buglyó, Miklós Udvardy, Dániel Beyer, György Vargha, Sándor Biró, László Rejtő
Dátum:	2016
ISSN:	1219-4956 1532-2807
Megjegyzések:	Expression of the gene Wilms tumor 1 (WT1) has been suggested as a marker of minimal residual disease in acute myeloid leukemia (AML), but literature data are not without controversy. Our aimwas to assess the presence, magnitude and temporal changes ofWT1 expression as prognostic factors. 60 AML patients were followed until death or the end of the 6-year observation period. Blood samples were taken at diagnosis, post-induction, during remission and in case of a relapse. Using quantitative real-time PCR, we determined WT1 expression from each sample, normalized it against the endogenous control gene glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and classified samples as negative, moderately positive or highly positive. We divided the patients into groups based on detected WT1 expression values, illustrated overall and disease-free survival on Kaplan-Meier curves, and compared differences between each group by the logrank test. Disappearance of WT1-positivity during chemotherapy had a favorable effect on survival. Interestingly, no difference was seen between the survivals of WT1-positive subgroups that expressed moderate or high levels of WT1 mRNA. A 1-log decrease in WT1 expression without becoming negative did not affect prognosis, either. Our results suggest that defining a cut-off value for WT1-positivity, rather than just using logarithmic figures of changes in gene expression, might have prognostic use in post-induction AML patients. We encourage further, larger-scale studies.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk WT1 gene Overexpression Quantitative real-time PCR Acute myeloid leukemia
Megjelenés:	Pathology & Oncology Research. - 22 : 1 (2016), p. 217-221. -
További szerzők:	Buglyó Gergely (1980-) (genetikus) Udvardy Miklós (1947-) (belgyógyász, haematológus) Beyer Dániel (1982-) (molekuláris biológus) Vargha György (1951-) (orvos) Biró Sándor (1949-) (molekuláris genetikus) Rejtő László (1963-) (belgyógyász, haematológus)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0025 TÁMOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM049188
035-os BibID:	PMID:24374862
Első szerző:	Ujj Zsófia
Cím:	WT1 Overexpression Affecting Clinical Outcome in Non-Hodgkin Lymphomas and Adult Acute Lymphoblastic Leukemia / Zsófia Ujj, Gergely Buglyó, Miklós Udvardy, György Vargha, Sándor Biró, László Rejtő
Dátum:	2014
ISSN:	1219-4956 1532-2807
Megjegyzések:	The Wilms tumor 1 (WT1) gene has a complex role as a transcriptional regulator, acting as tumor suppressor or oncogene in different malignancies. The prognostic role of its overexpression has been well-studied in leukemias, especially acute myeloid leukemia (AML), but not in lymphomas. For the first time to our knowledge, we present a study demonstrating the correlation of WT1 expression and survival in various non-Hodgkin lymphomas. We also studied the prognostic implications of WT1 overexpression in adult acute lymphoblastic leukemia (ALL). In our sample of 53 patients?25 with diffuse large B-cell lymphoma (DLBCL), 8 with mantle cell lymphoma (MCL), 9 with peripheral T-cell lymphoma (PTCL), 2 with Burkitt's lymphoma, 2 with mucosa-associated lymphoid tissue (MALT) lymphoma, and 7 with B-cell ALL?, we measured WT1 mRNA from blood samples by quantitative RT-PCR, and divided the patients into subgroups based on the level of expression. Kaplan?Meier survival curves were drawn and compared using the logrank test. In the sample of DLBCL patients, the difference in overall and disease-free survival between WT1-positive and negative subgroups was significant (p?=?0.0475 and p?=?0.0004, respectively), and in a few observed cases, a sudden increase in WT1 expression signified a relapse soon followed by death. Disease-free survival curves in MCL and ALL were similarly suggestive of a potential role played by WT1. In PTCL, though WT1-positivity was detected in 4 out of 9 cases, it did not seem to affect survival. The few cases of MALT and Burkitt's lymphoma all proved to be WT1-negative.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban WT1 gene Overexpression Non-Hodgkin lymphoma Diffuse large B-cell lymphoma Mantle cell lymphoma Acute lymphoblastic leukemia
Megjelenés:	Pathology & Oncology Research 20 : 3 (2014), p. 565-570. -
További szerzők:	Buglyó Gergely (1980-) (genetikus) Udvardy Miklós (1947-) (belgyógyász, haematológus) Vargha György (1951-) (orvos) Biró Sándor (1949-) (molekuláris genetikus) Rejtő László (1963-) (belgyógyász, haematológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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