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001-es BibID:	BIBFORM012817
Első szerző:	Muszbek László (haematológus, kutató orvos)
Cím:	Factor XIII and Atherothrombotic Diseases / Muszbek László, Bereczky Zsuzsanna, Bagoly Zsuzsa, Shemirani Amir-Houshang, Katona Éva
Dátum:	2010
ISSN:	0094-6176
Megjegyzések:	Factor XIII (FXIII) is a protransglutaminase that, after activation, cross-links fibrin chains and several plasma proteins, most importantly 2 plasmin inhibitor, to fibrin. FXIII strengthens the fibrin clot by covalent bonds and protects fibrin from the prompt elimination by the fibrinolytic system. In the last two decades, FXIII has emerged as a key regulator of fibrinolysis. FXIII is also present in platelets, monocytes, and macrophages, but this cellular form does not contribute significantly to maintaining hemostasis. FXIII deficiency is a life-threatening bleeding diathesis whose clinical consequences are well studied. In contrast, the involvement of FXIII in thrombotic disorders and its association with the risk of such diseases are less clear. This review gives an account of the data accumulated mainly in the last decade on the association of FXIII with atherothrombotic diseases and presents conclusions and hypotheses drawn from these data as well as exposing the limitations of the published studies and our knowledge on this topic. The involvement of FXIII in atherogenesis, its role in coronary artery disease, atherothrombotic ischemic stroke, and peripheral artery disease are discussed, with particular reference to the association of FXIII levels and polymorphisms with the risk of these diseases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Cardiovascular disease factor XIII factor XIII ploymorphisms peripheral artery disease stroke
Megjelenés:	Seminars in Thrombosis and Hemostasis. - 36 : 1 (2010), p. 018-033. -
További szerzők:	Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Bagoly Zsuzsa (1978-) (orvos) Shemirani, Amir-Houshang (1971-) (kutató orvos, laboratórium szakorvos) Katona Éva (1961-) (klinikai biokémikus)
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001-es BibID:	BIBFORM095056
035-os BibID:	(WoS)000673316300001 (Scopus)85110713637
Első szerző:	Szabó Gábor (PhD-hallgató)
Cím:	Laboratory Approaches to Test the Function of Antiphospholipid Antibodies / Gábor Szabó, Péter Antal-Szalmás, Adrienne Kerényi, Krisztina Pénzes, Bálint Bécsi, János Kappelmayer
Dátum:	2022
ISSN:	0094-6176
Megjegyzések:	Antiphospholipid syndrome (APS) is a systemic autoimmune disorder caused by the presence of aPLs (antiphospholipid antibodies, i.e., anti-?2-glycoprotein I and anticardiolipin). Everyday practice in terms of laboratory diagnostics of APS includes determination of aPLs and well-known functional assays assessing for lupus anticoagulant (LA), in turn using various tests. According to recent guidelines, the recommended method for LA identification or exclusion is based on the Russell Viper Venom test and a sensitive activated partial thromboplastin time assay. Despite the fact that LA can be quantified in laboratory practice in this way, LA is still used as a binary parameter that is just one of the risk factors of thrombosis in APS. As of today, there are no other functional assays to routinely assess the risk of thrombosis in APS. It is well-known that APS patients display a wide range of clinical outcomes although they may express very similar laboratory findings. One way to solve this dilemma, could be if antibodies could be further delineated using more advanced functional tests. Therefore, we review the diagnostic approaches to test the function of aPLs. We further discuss how thrombin generation assays, and rotational thromboelastometry tests can be influenced by LA, and how experimental methods, such as flow cytometric platelet activation, surface plasmon resonance, or nano differential scanning fluorimetry can bring us closer to the puzzling interaction of aPLs with platelets as well as with their soluble protein ligand. These novel approaches may eventually enable better characterization of aPL, and also provide a better linkage to APS pathophysiology.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk antiphospholipid antibodies
Megjelenés:	Seminars In Thrombosis And Hemostasis. - 48 : 2 (2022), p. 132-144. -
További szerzők:	Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Kerényi Adrienne (1970-) (laboratóriumi szakorvos) Pénzes-Daku Krisztina (1978-) (biológus) Bécsi Bálint (1981-) (vegyészmérnök) Kappelmayer János (1960-) (laboratóriumi szakorvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00044 GINOP OTKA_K_16 120725 OTKA GINOP-2.3.3-15-2016-00020 GINOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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