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001-es BibID:	BIBFORM117861
Első szerző:	Herman Tünde (orvos)
Cím:	Hashimoto's thyroiditis negatively influences ICSI outcome in euthyroid women on T4 substitution therapy; a retrospective study / Tünde Herman, Péter Török, Antonio Simone Laganà, Vito Chiantera, Renato Venezia, Attila Jakab
Dátum:	2024
ISSN:	0378-7346
Megjegyzések:	Abstract Objective: To analyze the impact of thyroid autoimmunity (TAI) on reproductive outcome parameters of ICSI cycles as compared to TAI negative ICSI cycles. Design: In this single IVF center retrospective study 86 infertile women with elevated TPOAb or TGAb levels, but euthyroid after thyroxine replacement (study group), were compared to 69 female patients with no thyroid abnormalities (controls). Following ICSI treatment fertilization rate (FR), clinical pregnancy rate (CPR), miscarriage rate (MR) and live birth rate (LBR) were analyzed. Materials, Setting, Methods: All subjects with various infertility factors were treated with ICSI in university based IVF center. Patients in the study group received thryroxine replacement and were euthyreoid at IVF treatment. Before the IVF cycles endocrinological parameters were uniformly assessed: thyroid function and antibodies, reproductive hormones (AMH, FSH, LH, E2, PRL, testosterone, DHEAS, 17-OHP, AD) and OGTT (0-60-120 min glucose and insulin). Following descriptive comparison of laboratory parameters, age adjusted analyses of FR, CPR, MR and LBR were performed. Results: TAI positive women were older (mean age 35.31?4.95 vs. 32.15?4.87 years; p=0.002), had higher FSH (8.4?3.4 vs. 7.4?2.32 U/L; p=0.024), higher E2 (53.94?47.61 vs. 42.93?18.92 pg/ml; p=0.025) levels, while AMH (2.88?2.62 vs. 3.61?1.69 ng/ml; p=0.0002) was lower. There were no differences in TSH levels (1.64?0.96 vs. 1.66?0.65 uIU/ml; p=0.652) between the two groups. FT3 (2.63?0.58 vs. 2.98?0.55 pg/ml; p=0.002) was lower and FT4 (1.3?0.29 vs. 1.13?0.21 ng/dl; p=0.0002) was higher in the TAI positive group, reflecting clinically irrevelant differences. Egg cell counts (6?3.8 vs. 7.5?3.95; p=0.015) were lower in TAI and remained so following age adjustment. Although the overall ICSI FR did not differ (62.9 % vs. 69.1 %, p=0.12), it was lower for patients under 35 with TAI showing decreasing differences in line with age. The CPR (36.04 % vs. 69.56 %; p<0.001), LBR (23.25 % vs. 60.86 %; p<0.001) were lower, the MR (35.48 % vs. 12.5 %; p=0.024) was higher in the TAI group and these differences remained after age adjustment. Limitations: Since the higher age of the study group may interfere with the effect of TAI, age adjustment calculations were necessary to perform to eliminate this confounding factor. Conclusion: Despite optimal thyroid supplementation in clinical or subclinical hypothyreoidism, the presence of TAI negatively influences clinical pregnancy rate and is connected to a higher miscarriage rate, thus resulting in a lower live birth rate after ICSI. Decreased fertilization rate with ICSI in TAI patients may also contribute to poorer outcomes, especially in younger women.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk IVF ICSI Hashimoto thyreoiditis
Megjelenés:	Gynecologic And Obstetric Investigation. - [Epub ahead of print] (2024). -
További szerzők:	Török Péter (1975-) (szülész-nőgyógyász) Laganà, Antonio Simone Chiantera, Vito Venezia, Renato Jakab Attila (1964-) (szülész-nőgyógyász, endokrinológus)
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001-es BibID:	BIBFORM075687
Első szerző:	Kozma Bence (szülész-nőgyógyász)
Cím:	The Effects of Heat Exposure on Vaginal Smooth Muscle Cells : elastin and Collagen Production / Bence Kozma, Keith Candiotti, Róbert Póka, Péter Takács
Dátum:	2018
ISSN:	0378-7346
Megjegyzések:	Aims: To evaluate smooth muscle cells (SMCs) proliferation and elastin and collagen production after heat exposure (65 ? C). Methods: Samples were taken from the anterior vaginal wall, SMCs were cultured, and heated to 65 ? C for 30 and 60 s. Cell proliferation was assessed; tropoelastin and collagen production was measured. Results: Heat does not affect SMC proliferation at 65 ? C neither at 30 nor at 60 s. Surfacedeposited elastin level was significantly increased after heat exposure (mean ? SD, 30 s 155 ? 5% of control [p < 0.01] and 60 s 516 ? 40% of control [p < 0.01]). Tropoelastin levels in the culture media were significantly lower after 60 s of heat exposure (mean ? SD, 30 s 102 ? 5% of control [p = ns] and 60 s 70 ? 2% of control [p = 0.04]). Significant increase in surface-deposited collagen production was found (mean ? SD, 30 s 170 ? 6% of control [p < 0.01] and 60 s 123 ? 6% of control [p < 0.01]), but no such elevation was measured in the media after heat exposure (mean ? SD, 30 s 120 ? 20% of control [p = ns] and 60 s 100 ? 20% of control [p = ns]). Conclusion: When SMCs are exposed to heat there is significant elevation in collagen and elastin production. Changes in the composition of the extracellular matrix after heat exposure may contribute to vaginal wall remodeling.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Gynecologic And Obstetric Investigation. - 83 : 3 (2018), p. 247-251. -
További szerzők:	Candiotti, Keith Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Takács Péter (1968-) (szülész-nőgyógyász)
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