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001-es BibID:	BIBFORM033815
Első szerző:	András Csilla (onkológus szakorvos)
Cím:	Correlations between Clinicopathological Parameters and Molecular Signatures of Primary Tumors for Patients with Stage T3N0 Colorectal Adenocarcinomas: A Single Center Retrospective Study on 100 Cases / Csilla András, László Tóth, Csaba Molnár, Miklós Tanyi, Zoltán Csiki, Balázs Dezső, János Pósán, Amir-Houshang Shemirani, Emese Csiki, János Szántó
Dátum:	2012
ISSN:	0172-6390
Megjegyzések:	Background/Aims: To examine the clinical and protein expression characteristics of tumor tissues for prediction of prognosis in colorectal cancer (CRC). Methodology: We retrospectively analyzed the clinicopathological data of patients with stage T3N0 CRC, operated between 1997-2003 and the surgical materials for the relation between disease prognosis and p53, p21, p16, β-catenin, E-cadherin, EGFR, hMLH1, hMSH2 and TS protein expressions. Results: A significantly shorter 3-year disease free survival was observed in patients under the age of 50. The worst 5-year overall survival (OS) observed for patients over 70. Tumor localization and number of processed lymph nodes significantly affected prognosis. The EGFR, hMSH2 and TS expressions and the 5-fluorouracyl treatment were not found to be of prognostic value; p53 and p21 positivity had significantly worse survival. When catenin membrane expression disappeared on tumor cells, the 5-year OS rate decreased and time to metastasis shortened significantly. Membrane catenin expression, processed lymph nodes number and age were detected as independent prognostic markers. Conclusions: These results suggest that the evaluation of a clinicopathological profile, based on age, tumor localization, number of examined lymph nodes, p53, p21 and E-cadherin catenin expression appears to be useful in identifying high risk patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Hepato-Gastroenterology. - 59 : 116 (2012), p. 1091-1097. -
További szerzők:	Tóth László (1971-) (patológus) Molnár Csaba (1979-) (pathológus) Tanyi Miklós (1968-) (sebész) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Dezső Balázs (1951-) (pathológus) Pósán János (1976-) (sebész) Shemirani, Amir-Houshang (1971-) (kutató orvos, laboratórium szakorvos) Csiki Emese (1986-) (onkoradiológus) Szántó János (1949-) (onkológus szakorvos)
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001-es BibID:	BIBFORM040859
Első szerző:	Bodnár Zsolt (sebész)
Cím:	The abdominal compartment syndrome (ACS) in general surgery / Zsolt Bodnár, Sándor Sipka, Zoltán Hajdu
Dátum:	2008
Megjegyzések:	BACKGROUND: The abdominal compartment syndrome is a life threatening clinical entity which can develop within the first 12 hours of intensive care unit admission in high-risk surgical patients. The aim of this paper is to show the definitions, ethiology, pathophysiology, diagnosis and treatment of this serious, not only surgical problem. METHODOLOGY: The mortality due to the abdominal compartment syndrome is extremely high (38-71%). It can be defined as adverse physiologic consequences that occur as a result of an acute increase in the intraabdominal pressure. The most common causes are retroperitoneal haemorrhage, visceral oedema, pancreatitis, bowel obstruction, tense ascites, peritonitis, tumor. The mostly affected systems are cardiovascular, pulmonary, renal, central nervous systems and splanchnic organs. The gold standard diagnostic method is the continuous intra-abdominal pressure monitoring. The treatment consists of adequate fluid resuscitation and surgical decompression. RESULTS: We show three typical short case reports treated by the above mentioned theories. CONCLUSIONS: Intraabdominal hypertension and abdominal compartment syndrome are frequent clinical findings among acute general surgical patients. Patients with comparable demographics and acute severity of illness are more likely to die if intraabdominal hypertension or abdominal compartment syndrome is present. We conclude that the early recognition and surgical decompression is urgent.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Hepato-Gastroenterology. - 55 : 88 (2008), p. 2033-2038. -
További szerzők:	Sipka Sándor (1945-) (laboratóriumi szakorvos) Hajdú Zoltán (sebész)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM006272
Első szerző:	Furka Andrea (sebész)
Cím:	Surgical treatment of liver metastases from breast cancer / Andrea Furka, László Halász, Zsolt Szentkereszty, János Pósán, Csilla András, Péter Sápy
Dátum:	2008
Megjegyzések:	The resection of colorectal liver metastases is currently a well accepted and effective treatment. In the past decade liver metastases of breast cancer have been treated more frequently by surgical intervention. Methodology: The authors retrospectively studied the data of 17 operated patients, and investigated the clinical features of liver metastases, lymph node involvement ofprimary tumor, the indications of operations, and early and late results of the treatment. Results: The solitary metastasis and demarcated multipÍe metastases, whichseemed (by CT scan) to be operable by Ro resection were among the surgical indications. Different segment resections, 3 laparoscopic resections and one hemihepatectomy were performed. There were no deaths in the peri-operative period, though there were two minor postoperative complications in two cases. AlI patients received chemotherapy. By follow-up, three breast cancer patients died, whose average survival rate was 19.25 months. The other patients' average Jollow- up time was 15.17 months, without relapse. Conclusions: In conclusion it appears that in selected cases resection of liver metastases can be safely performed and the survival rate is reasonable.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Breast cancer Liver metastasis Liver resection Survival rate
Megjelenés:	Hepato-Gastroenterology. - 55 : 85 (2008), p. 1416-1418. -
További szerzők:	Halász László Szentkereszty Zsolt (1961-) (sebész) Pósán János (1976-) (sebész) András Csilla (1961-) (onkológus szakorvos) Sápy Péter (1942-) (sebész)
Internet cím:	elektronikus változat
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