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1.

001-es BibID:BIBFORM015788
Első szerző:Bodnár Nóra (reumatológus)
Cím:Assessment of subclinical vascular disease associated with ankylosing spondylitis / Bodnár N., Kerekes G., Seres I., Paragh G., Kappelmayer J., Némethné Gyurcsik Zs., Szegedi G., Shoenfeld Y., Sipka S., Soltész P., Szekanecz Z., Szántó S.
Dátum:2011
ISSN:0315-162X
Megjegyzések:Studies indicate that ankylosing spondylitis (AS), as well as rheumatoid arthritis, may be associated with accelerated atherosclerosis and vascular disease. We assessed endothelial dysfunction, carotid atherosclerosis, and aortic stiffness in AS in context with clinical and laboratory measurements. METHODS: Forty-three patients with AS and 40 matched healthy controls were studied. We assessed common carotid intima-media thickness (ccIMT), flow-mediated vasodilation (FMD), and pulse-wave velocity (PWV) in association with age, disease duration, smoking habits, body mass index, patient's assessment of pain and disease activity, Bath AS Disease Activity Index, Bath AS Functional Index (BASFI), metric measurements, erythrocyte sedimentation rate, C-reactive protein, and HLA-B27 status. RESULTS: We found impaired FMD (6.85 +/- 2.98% vs 8.30 +/- 3.96%; p = 0.005), increased ccIMT (0.65 +/- 0.15 vs 0.54 +/- 0.15 mm; p = 0.01), and higher PWV (8.64 +/- 2.44 vs 8.00 +/- 1.46 m/s; p = 0.03) in patients with AS compared to controls, respectively. We also found that ccIMT negatively correlated with FMD (r = -0.563; p = 0.0001) and positively correlated with PWV (r = 0.374; p = 0.018). Both ccIMT and PWV correlated with disease duration (r = 0.559; p = 0.013 and r = 0.520; p = 0.022, respectively), BASFI (r = 0.691; p = 0.003 and r = 0.654; p = 0.006), decreased lumbar spine mobility (r = -0.656; p = 0.006 and r = -0.604; p = 0.013), chest expansion (r = -0.502; p = 0.047 and r = -0.613; p = 0.012), and increased wall-occiput distance (r = 0.509; p = 0.044 and r = 0.614; p = 0.011). CONCLUSION: In this well characterized AS population, impaired FMD and increased ccIMT and PWV indicate abnormal endothelial function and increased atherosclerosis and aortic stiffness, respectively. The value of noninvasive diagnostic tools needs to be further characterized.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Rheumatology. - 38 : 4 (2011), p. 723-729. -
További szerzők:Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Kappelmayer János (1960-) (laboratóriumi szakorvos) Némethné Gyurcsik Zsuzsanna (1976-) (gyógytornász) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Shoenfeld, Yehuda Sipka Sándor (1945-) (laboratóriumi szakorvos) Soltész Pál (1961-) (belgyógyász, kardiológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szántó Sándor (1968-) (belgyógyász, reumatológus)
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2.

001-es BibID:BIBFORM081053
035-os BibID:(PMID)31522318
Első szerző:Gulyás Katalin (reumatológus)
Cím:Effects of 1-year anti-TNF-[alfa] therapies on bone mineral density and bone biomarkers in rheumatoid arthritis and ankylosing spondylitis / Katalin Gulyás, Ágnes Horváth, Edit Végh, Anita Pusztai, Ágnes Szentpétery, Zsófia Pethö, Andrea Váncsa, Nóra Bodnár, Péter Csomor, Attila Hamar, Levente Bodoki, Harjit Pal Bhattoa, Balázs Juhász, Zoltán Nagy, Katalin Hodosi, Tamás Karosi, Oliver FitzGerald, Gabriella Szücs, Zoltán Szekanecz, Szilvia Szamosi, Sándor Szántó
Dátum:2020
ISSN:0770-3198
Megjegyzések:OBJECTIVES: Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have been associated with generalized and localized bone loss. We conducted a comprehensive study using imaging (dual-energy X-ray absorptiometry, DXA) and laboratory biomarkers in order to determine bone health and to study the effects of anti-tumor necrosis factor (TNF) biologics in RA and AS. PATIENTS AND METHODS: Thirty-six RA and 17 AS patients undergoing 1-year etanercept (ETN) or certolizumab-pegol (CZP) therapy were studied. Bone density was assessed by DXA at baseline and after 12 months. Serum C-reactive protein (CRP), calcium, phosphate, parathyroid hormone (PTH), vitamin D3, osteocalcin, procollagen type I N-propeptide (P1NP), C-terminal telopeptide (βCTX), osteoprotegerin, sclerostin (SOST), Dickkopf-1 (DKK-1), soluble receptor activator nuclear kappa B ligand (sRANKL), and cathepsin K (cathK) levels were determined at baseline and after 6 and 12 months. RESULTS: TNF-α inhibition was clinically effective. Anti-TNF-α halted further bone loss over 1 year. In general, anti-TNF therapy significantly increased P1NP, SOST levels, and the P1NP/βCTX ratios, while decreased DKK-1 and CathK production at different time points in most patient subsets. In the full cohort and in RA, baseline and/or 12-month bone mineral density (BMD) at multiple sites exerted inverse relationships with CRP and βCTX, and positive correlation with SOST. In AS, L2-4 BMD after 1-year biologic therapy inversely correlated with baseline βCTX, while femoral neck BMD rather showed inverse correlations with CRP. CONCLUSIONS: Anti-TNF therapy slowed down generalized bone loss, in association with clinical improvements, in both diseases. TNF blockade may enhance bone formation and suppress joint destruction. Anti-TNF therapy may act inversely on DKK-1 and SOST. Independent predictors of BMD were SOST and βCTX in RA, whilst CRP in AS. Key Points ? One-year anti-TNF therapy halted generalized bone loss in association with clinical improvement in arthritides. ? Anti-TNF therapy may inversely act on DKK-1 and SOST. ? Independent predictors of BMD were SOST and βCTX in RA, while CRP in AS.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Biologics
Bone loss
DKK-1
Erosion
JAK inhibitors
Osteoporosis
Osteoprotegerin
RANKL
Rheumatoid arthritis
Sclerostin
Spondyloarthritis
Syndesmophyte
Megjelenés:Clinical Rheumatology. - 39 : 1 (2020), p. 167-175. -
További szerzők:Horváth Ágnes (1985-) (reumatológus) Végh Edit (1978-) (reumatológus, belgyógyász) Karancsiné Pusztai Anita (1989-) (tudományos segédmunkatárs) Szentpétery Ágnes (1978-) (reumatológus) Pethő Zsófia (1981-) (reumatológus, immunológus) Váncsa Andrea (1972-) (orvos) Bodnár Nóra (1980-) (reumatológus) Csomor Péter (1984-) (biotechnológus) Hamar Attila Béla (1990-) (általános orvos) Bodoki Levente (1986-) (PhD hallgató) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Juhász Balázs (1973-) (orvos, onkológus) Nagy Zoltán (orvos) Hódosi Katalin Karosi Tamás (1979-) (fül-orr-gégész) FitzGerald, Oliver Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szamosi Szilvia (1975-) (belgyógyász, reumatológus) Szántó Sándor (1968-) (belgyógyász, reumatológus)
Pályázati támogatás:K 105073
OTKA
TÁMOP-4.2.4.A/2-11/1-2012-0001
TÁMOP
GINOP-2.3.2-15-2016-00015
GINOP
GINOP-2.3.2-15-2016-00050
GINOP
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3.

001-es BibID:BIBFORM090153
Első szerző:Karancsiné Pusztai Anita (tudományos segédmunkatárs)
Cím:Soluble vascular biomarkers in rheumatoid arthritis and ankylosing spondylitis : effects of one-year anti-TNF-[alfa] therapy / Anita Pusztai, Attila Hamar, Ágnes Horváth, Katalin Gulyás, Edit Végh, Nóra Bodnár, György Kerekes, Monika Czókolyová, Levente Bodoki, Katalin Hodosi, Andrea Domján, Gábor Nagy, Ibolya Szöllősi, Luis R. Lopez, Eiji Matsuura, Zoltán Prohászka, Sándor Szántó, Gabriella Szűcs, Zoltán Nagy, Yehuda Shoenfeld, Zoltán Szekanecz, Szilvia Szamosi
Dátum:2021
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:The Journal of Rheumatology. - 48 : 6 (2021), p. 821-828. -
További szerzők:Hamar Attila Béla (1990-) (általános orvos) Horváth Ágnes (1985-) (reumatológus) Gulyás Katalin (reumatológus) Végh Edit (1978-) (reumatológus, belgyógyász) Bodnár Nóra (1980-) (reumatológus) Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Czókolyová Mónika (1993-) (molekuláris biológus) Bodoki Levente (1986-) (PhD hallgató) Hódosi Katalin Domján Andrea (1979-) (reumatológus) Nagy Gábor (1974-) (laboratóriumi szakorvos, laboratóriumi hematológus és immunológus) Szöllősi Ibolya Lopez, Luis R. Matsuura, Eiji Prohászka Zoltán Szántó Sándor (1968-) (belgyógyász, reumatológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nagy Zoltán Shoenfeld, Yehuda Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szamosi Szilvia (1975-) (belgyógyász, reumatológus)
Pályázati támogatás:TÁMOP-4.2.4.A/2-11/1-2012-0001
TÁMOP
GINOP-2.3.2-15-2016-00050
GINOP
Internet cím:DOI
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4.

001-es BibID:BIBFORM072268
Első szerző:Kardos Zsófia
Cím:Increased frequency of temporal acoustic window failure in rheumatoid arthritis : a manifestation of altered bone metabolism? / Kardos Zsófia, Oláh Csaba, Sepsi Mariann, Sas Attila, Kostyál László, Bóta Tünde, Bhattoa Harjit Pal, Hodosi Katalin, Kerekes György, Tamási László, Bereczki Dániel, Szekanecz Zoltán
Dátum:2018
ISSN:0770-3198
Megjegyzések:Assessment of intracranial vessels includes transcranial Doppler (TCD). TCD performance requires intact temporal acousticwindows (TAW). Failure of TAW (TAWF) is present in 8?20% of people. There have been no reports on TAWF in rheumatoidarthritis (RA). Altogether, 62 female RA patients were included. Among them, 20 were MTX-treated and biologic-free, 20received infliximab, and 22 tocilizumab. The controls included 60 non-RA women. TAWF, temporal bone thickness, and texturewere determined by ultrasound and CT. BMD and T-scores of multiple bones were determined by DEXA. Several bonebiomarkers were assessed by ELISA. In RA, 54.8% of the patients had TAWF on at least one side. Neither TAW could beidentified in 34% of RA subjects. In contrast, only 20.0% of control subjects had TAWF on either or both sides (p < 0.001). In RAvs controls, 53.0 vs 2.9% of subjects exerted the trilayer, Bsandwich-like^ structure of TAW (p < 0.001). Finally, in RA vscontrols, the mean temporal bone thickness values of the right TAW were 3.58 ? 1.43 vs 2.92 ? 1.22 mm (p = NS), while thoseof the left TAW were 4.16 ? 1.56 vs 2.90 ? 1.16 mm (p = 0.001). There was close association between TAWF, bone thickness,and texture (p < 0.05). These TAW parameters all correlated with age; however, TAW failure and texture also correlated withserum osteoprotegerin. TAW bone thickness inversely correlated with hip BMD (p < 0.05). TAWF, thicker, and heterogeneoustemporal bones were associated with RA. These features have been associated with bone loss and OPG production. Bone lossseen in RA may result in OPG release and stimulation of bone formation around TAW.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Biological therapy
BMD
Osteoporosis
Osteoprotegerin
Reumatoid arthritis
Temporal acoustic window failure
Megjelenés:Clinical Rheumatology. - 37 : 5 (2018), p. 1183-1188. -
További szerzők:Oláh Csaba (1972-) (idegsebész) Sepsi Marianna Sas Attila Kostyál László (1974-) (radiológus) Bóta Tünde Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Hódosi Katalin Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Tamási László Bereczki Dániel (1960-) (neurológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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5.

001-es BibID:BIBFORM054431
Első szerző:Kerekes György (belgyógyász, kardiológus, angiológus)
Cím:Rheumatoid arthritis and metabolic syndrome / György Kerekes, Michael T. Nurmohamed, Miguel A. González-Gay, Ildikó Seres, György Paragh, Zsófia Kardos, Zsuzsa Baráth, László Tamási, Pál Soltész, Zoltán Szekanecz
Dátum:2014
ISSN:1759-4790 1759-4804
Megjegyzések:Rheumatoid arthritis (RA), especially active disease, is associated with considerable changes in body composition, lipids, adipokines and insulin sensitivity. Metabolic changes, such as increased total cholesterol, LDL cholesterol and triglyceride levels, occur even in preclinical RA. Active RA is associated with decreased lipid levels, BMI, fat and muscle mass, as well as altered lipid profiles. Some of these changes are also seen in metabolic syndrome, and could increase cardiovascular mortality. Importantly, the systemic inflammation underlying RA is an independent risk factor for cardiovascular disease. This Perspectives article summarizes data on the associations of various components of metabolic syndrome with RA, and discusses the effects of biologic therapy on these factors. The authors propose that components of metabolic syndrome should be monitored in patients with RA throughout the disease course, and argue that optimal disease control using biologic agents might attenuate several adverse effects of metabolic syndrome in these patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
undifferentiated connetice tissue disease
entholtelial cell markers
endothelial dísfunction
flow-mediated vasodilation
accelered atherosclerosis
Megjelenés:Nature Reviews Rheumatology 10 : 11 (2014), p. 691-696. -
További szerzők:Nurmohamed, Michael T. Gonzalez-Gay, Miguel A. Seres Ildikó Paragh György (1953-) (belgyógyász) Kardos Zsófia Baráth Zsuzsa Tamási László Soltész Pál (1961-) (belgyógyász, kardiológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0031
TÁMOP
TÁMOP-4.2.2.A-11/1/KONV-2012-0031
TÁMOP
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6.

001-es BibID:BIBFORM049171
Első szerző:Kobezda Tamás (Ph.D hallgató)
Cím:Of mice and men : how animal models advance our understanding of T-cell function in RA / Tamás Kobezda, Sheida Ghassemi-Nejad, Katalin Mikecz, Tibor T. Glant, Zoltán Szekanecz
Dátum:2014
ISSN:1759-4790 1759-4804
Megjegyzések:The involvement of autoreactive T cells in the pathogenesis of rheumatoid arthritis (RA) as well as in autoimmune animal models of arthritis has been well established; however, unanswered questions, such as the role of joint-homing T cells, remain. Animal models of arthritis are superb experimental tools in demonstrating how T cells trigger joint inflammation, and thus can help to further our knowledge of disease mechanisms and potential therapies. In this Review, we discuss the similarities and differences in T-cell subsets and functions between RA and mouse arthritis models. For example, various T-cell subsets are involved in both human and mouse arthritis, but differences might exist in the cytokine regulation and plasticity of these cells. With regard to joint-homing T cells, an abundance of synovial T cells is present in humans compared with mice. On the other hand, local expansion of type 17 T-helper (TH17) cells is observed in some animal models, but not in RA. Finally, whereas T-cell depletion therapy essentially failed in RA, antibody targeting of T cells can work, at least preventatively, in most arthritis models. Clearly, additional human and animal studies are needed to fill the gap in our understanding of the specific contribution of T-cell subsets to arthritis in mice and men.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
T-cell responses
T-cell clonal expansion
Megjelenés:Nature Reviews Rheumatology. - 10 : 3 (2014), p. 160-170. -
További szerzők:Ghassemi-Nejad, Sheida (1980-) (fogorvos) Mikecz Katalin Glant Tibor T. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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7.

001-es BibID:BIBFORM035605
035-os BibID:PMID:22198694
Első szerző:Némethné Gyurcsik Zsuzsanna (gyógytornász)
Cím:Improvement in pain intensity, spine stiffness, and mobility during a controlled individualized physiotherapy program in ankylosing spondylitis / Zsuzsanna Némethné Gyurcsik, Anita András, Nóra Bodnár, Zoltán Szekanecz, Sándor Szántó
Dátum:2012
ISSN:0172-8172
Megjegyzések:Physical therapy in ankylosing spondylitis (AS)is important for maintaining or improving mobility, fitness,functioning, and global health. It also plays a role in theprevention and management of structural deformities. Inthis study we assessed the functional status of AS patientsin relation to disease duration and activity. Furthermore, involunteering patients we analyzed the efficacy of a controlled,individualized physiotherapeutic program. Altogether,clinical data of 75 AS patients were retrospectivelyanalyzed. Anthropometrical data, duration since diagnosisand disease activity, pain intensity, tender points, sacroiliacjoint involvement determined by X-ray, functional condition,and physical activity level were recorded. Subjective,functional, and physical tests were performed. Out of the75 patients, 10 volunteered to undergo a complex physicalexercise program twice a week for 3 months. The programincluded 1.5 h of general posture reeducation, manualmobilization of the spine, and pelvic-, upper-, and lowerextremityexercises, stretching with joint prevention strategiesand functional exercises. In AS, pain intensityrecorded on a 10-cm visual analog scale (VAS), BASFI,BASDAI, modified Schober index, chest expansion andocciput-to-wall distance values showed significant correlationwith disease activity. The 3-month physical therapyimproved several subjective and functional parameters, and markedly reduced pain intensity and spine stiffness. Acomplex, individualized physical therapy program may beuseful and should be introduced to AS patients in order tomaintain and increase spine mobility, preserve functionalcapacity, decrease the pain and stiffness.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Ankylosing spondylitis
Pain
Stiffness
Tender points
Mobility
Physiotherapy
egyetemen (Magyarországon) készült közlemény
Megjelenés:Rheumatology International 32 : 12 (2012), p. 3931-3936. -
További szerzők:András Anita (1976-) (gyógytornász) Bodnár Nóra (1980-) (reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szántó Sándor (1968-) (belgyógyász, reumatológus)
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8.

001-es BibID:BIBFORM084306
Első szerző:Oláh Csaba (idegsebész)
Cím:Assessment of cervical spine involvement in rheumatoid arthritis patients in the era of biologics : a real-life, cross-sectional MRI study / Csaba Oláh, Kardos Zsófia, Kostyál László, Hodosi Katalin, Tamási László, Bereczki Dániel, Szekanecz Zoltán
Dátum:2020
ISSN:0172-8172 1437-160X
Megjegyzések:Cervical spine involvement may lead to severe complications in rheumatoid arthritis (RA). In the era of modern therapies, atlantoaxial subluxation (AAS) may be rare; however, it may still be detected in asymptomatic patients. The onset of myelopathy can occur at any time. Altogether 49 female RA patients were included. Among them, 15 were methotrexate treated, biologic free, while 34 patients received biologics. The patients had no cervical pain or any neurological symptoms. We assessed the first (C1) and second (C2) cervical vertebrae by 3?T magnetic resonance imaging (MRI). In addition to AAS, we also determined odontoid erosion or periodontal soft tissue thickening. We associated our MRI findings with clinical, laboratory parameters, and hand radiography. We detected anterior AAS and soft tissue thickening in one-quarter, while odontoid erosions in eight (16%) of RA patients. There were no significant differences among the therapeutic subgroups. No posterior or vertical AAS was seen. Anterior AAS was associated with higher degree of inflammation, soft tissue thickening was seen at younger age, while odontoid erosions were associated with van der Heijde?Sharp scores of the hand. None of the patients had any lesions requiring surgery. The presence of cervical involvement in RA patients with 10?11?years of disease duration is still an important and frequent phenomenon. Higher disease activity and erosive disease are associated with atlantoaxial involvement. 3?T MRI is a sensitive method to assess AAS, as well as soft tissue lesions and odontoid erosions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Rheumatoid arthritis
Atlantoaxial subluxation
Cervical spine involvement
Odontoid erosion
Megjelenés:Rheumatology International. - 40 : 6 (2020), p. 915-921. -
További szerzők:Kardos Zsófia Kostyál László (1974-) (radiológus) Hódosi Katalin Tamási László Bereczki Dániel (1960-) (neurológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Pályázati támogatás:TAMOP-4.2.4.A/2-11/1-2012-0001
TÁMOP
GINOP-2.3.2-15-2016-00015
GINOP
GINOP-2.3.2-15-2016-00050
GINOP
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9.

001-es BibID:BIBFORM081586
Első szerző:Oláh Csaba (idegsebész)
Cím:Assessment of cognitive function in female rheumatoid arthritis patients : associations with cerebrovascular pathology, depression and anxiety / Oláh Csaba, Kardos Zsófia, Andrejkovics Mónika, Szarka Enikő, Hodosi Katalin, Domján Andrea, Sepsi Marianna, Sas Attila, Kostyál László, Fazekas Katalin, Flórián Ágnes, Lukács Katalin, Miksi Ágnes, Baráth Zsuzsanna, Kerekes György, Péntek Márta, Valikovics Attila, Tamási László, Bereczki Dániel, Szekanecz Zoltán
Dátum:2020
ISSN:0172-8172 1437-160X
Megjegyzések:We assessed cognitive function of female rheumatoid arthritis (RA) patients and analyze the determinants, with special focus on cerebrovascular morphology. Sixty methotrexate (MTX-) or biologic-treated RA patients and 39 healthy controls were included in a cross-sectional study. Smoking habits, alcohol intake and time spent in education were recorded. Standard measures were performed to assess cognitive function (Montreal Cognitive Assessment, MOCA; Trail Making Test, TMT; Victoria Stroop Test, VST; Wechsler Adult Intelligence Scale, WAIS; Benton Visual Retention test, BVRT), depression (Beck Depression Inventory, BDI), anxiety (State-Trait Anxiety Inventory, STAIT/S) and general health status (Short Form 36, SF-36). Mean disease activity (28-joint Disease Activity Score, mDAS28; erythrocyte sedimentation rate, mESR; C-reactive protein, mCRP) of the past 12 months was calculated; anti-cyclic citrullinated peptide (CCP) and rheumatoid factor (RF) were assessed. Cerebral vascular lesions and atrophy, carotid intima?media thickness (cIMT) and plaques, as well as median cerebral artery (MCA) circulatory reserve capacity (CRC) were assessed by brain magnetic resonance imaging (MRI), carotid ultrasound and transcranial Doppler, respectively. Cognitive function tests showed impairment in RA vs controls. Biologic- vs MTX-treated subgroups differed in TMT-A. Correlations were identified between cognitive function and depression/anxiety tests. WAIS, STAIS, STAIT and BDI correlated with most SF-36 domains. Numerous cognitive tests correlated with age and lower education. Some also correlated with disease duration, mESR and mDAS28. Regarding vascular pathophysiology, cerebral vascular lesions were associated with VST-A, carotid plaques with multiple cognitive parameters, while MCA and CRC with MOCA, BVRT and BDI. RA patients have significant cognitive impairment. Cognitive dysfunction may occur together with or independently of depression/anxiety. Older patients and those with lower education are at higher risk to develop cognitive impairment. Cognitive screening might be a useful tool to identify subgroups to be further investigated for cerebrovascular pathologies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Rheumatoid arthritis
Cognitive dysfunction
Cerebrovascular disease
Transcranial Doppler
Carotid artery
Methotrexate
Biological therapy
Megjelenés:Rheumatology International. - 40 : 4 (2020), p. 529-540. -
További szerzők:Kardos Zsófia Andrejkovics Mónika (1967-) (klinikai szakpszichológus, neuropszichológus, pszichoterapeuta) Szarka Enikő Hódosi Katalin Domján Andrea (1979-) (jogász, egészségügyi menedzser) Sepsi Marianna Sas Attila Kostyál László (1974-) (radiológus) Fazekas Katalin (orvos) Flórián Ágnes Lukács Katalin Miksi Ágnes Baráth Zsuzsa Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Péntek Márta Valikovics Attila Tamási László Bereczki Dániel (1960-) (neurológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Pályázati támogatás:TAMOP-4.2.4.A/2-11/1-2012-0001
TÁMOP
GINOP-2.3.2-15-2016-00050
GINOP
GINOP-2.3.2-15-2016-00015
GINOP
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

10.

001-es BibID:BIBFORM071108
Első szerző:Szentpétery Ágnes (reumatológus)
Cím:Striking difference of periarticular bone density change in early psoriatic arthritis and rheumatoid arthritis following anti-rheumatic treatment as measured by digital X-ray radiogrammetry / Agnes Szentpetery, Eric Heffernan, Muhammad Haroon, Mark Kilbane, Phil Gallagher, Malachi J. McKenna, Oliver FitzGerald
Dátum:2016
ISSN:1462-0324
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Rheumatology 55 : 5 (2016), p. 891-896. -
További szerzők:Heffernan, Eric Haroon, Muhammad Kilbane, Mark Gallagher, Phil McKenna, Malachi J. FitzGerald, Oliver
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

11.

001-es BibID:BIBFORM071109
Első szerző:Szentpétery Ágnes (reumatológus)
Cím:Periarticular bone gain at proximal interphalangeal joints and changes in bone turnover markers in response to tumor necrosis factor inhibitors in rheumatoid and psoriatic arthritis / Agnes Szentpetery, Malachi J. McKenna, Barbara F. Murray, Chin Teck Ng, Jennifer J. Brady, Michelle Morrin, Bea Radovits, Douglas J. Veale, Oliver FitzGerald
Dátum:2013
ISSN:0315-162X 1499-2752
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Rheumatology 40 : 5 (2013), p. 653-662. -
További szerzők:McKenna, Malachi J. Murray, Barbara F. Ng, Chin Teck Brady, Jennifer J. Morrin, Michelle Radovits Bea Veale, Douglas J. FitzGerald, Oliver
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM007142
Első szerző:Szűcs Gabriella (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Cím:Endothelial dysfunction precedes atherosclerosis in systemic sclerosis - relevance for prevention of vascular complications / Szucs, G., Timar, O., Szekanecz, Z., Der, H., Kerekes, G., Szamosi, S., Shoenfeld, Y., Szegedi, G., Soltesz, P.
Dátum:2007
ISSN:1462-0324 (Print)
Megjegyzések:The pathogenesis of systemic sclerosis (SSc) includes vasculopathy with endothelial dysfunction. The aim of this study was to investigate endothelium-dependent, flow-mediated dilatation (FMD), as well as endothelium-independent, nitroglycerin-mediated dilatation (NMD) of the brachial artery and to assess common carotid intimal-medial thickness (ccIMT) in SSc patients compared with healthy controls. METHODS: FMD and NMD of the brachial artery were determined using high-resolution ultrasound imaging and the values were expressed as percentage change from baseline in 29 SSc patients and 29 healthy controls. The two groups were very similar regarding sex, age and traditional cardiovascular risk factors. In addition, common carotid arteries were assessed by duplex colour ultrasound, ccIMT determined using high resolution ultrasound and expressed in mm thickness in the same patients and controls. Correlations between FMD, NMD, ccIMT, age and the SSc subtype (diffuse or limited form) were analysed. RESULTS: In the 29 SSc patients (mean age: 51.8 yrs), the FMD was significantly lower (4.82 +/- 3.76%) in comparison with the controls (8.86 +/- 3.56%) (P < 0.001). No difference was found in NMD between patients (19.13 +/- 17.68%) and controls (13.13 +/- 10.40%) (P > 0.1). There was a tendency of increased ccIMT in SSc patients (0.67 +/- 0.26 mm) compared with healthy subjects (0.57 +/- 0.09), but this difference was not significant (P = 0.067). A significant, positive correlation between ccIMT and age in SSc (r = 0.470, P = 0.013) was detected, as well as in healthy controls (r = 0.61, P = 0.003), but no correlation was found between FMD and age. In addition, ccIMT, but not FMD and NMD, displayed significant correlation with disease duration (r = 0.472, P = 0.011). NMD displayed significant inverse correlation with the age in SSc patients (r = -0.492, P = 0.012), but not in controls. We did not find any correlation between FMD, NMD, ccIMT and SSc subtype. CONCLUSIONS: There is an impairment of endothelium-dependent vasodilatation indicated by low FMD in SSc. At the same time, the endothelium-independent dilatation assessed by NMD is still preserved giving an opportunity of nitroglycerine therapy. Carotid atherosclerosis indicated by ccIMT may occur at higher ages and after longer disease duration. Thus, the assessment of FMD in the pre-atherosclerotic stage may have a beneficial diagnostic, prognostic and therapeutic relevance.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adult
Age Factors
Aged
Atherosclerosis
Brachial Artery
Carotid Artery, Common
Endothelium, Vascular
Female
Humans
Male
Middle Aged
Nitroglycerin
Prognosis
Risk Factors
Scleroderma, Systemic
Time Factors
Tunica Intima
Tunica Media
Vasodilation
Vasodilator Agents
Megjelenés:Rheumatology. - 46 : 5 (2007), p. 759-762. -
További szerzők:Tímár Orsolya (1980-) (belgyógyász) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Dér Henrietta (1977-) (orvos) Kerekes György (1973-) (belgyógyász, kardiológus, angiológus) Szamosi Szilvia (1975-) (belgyógyász, reumatológus) Shoenfeld, Yehuda Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Soltész Pál (1961-) (belgyógyász, kardiológus)
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elektronikus változat
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