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001-es BibID:	BIBFORM076676
035-os BibID:	(cikkazonosító)8670398 (WOS)000458978300001 (Scopus)85062331886
Első szerző:	Gergely Péter (igazságügyi orvosszakértő)
Cím:	Tyrosine kinase inhibitor Imatinib mesylate alters DMBA-induced early onco/suppressor-gene expression with tissue-specificity in mice / Péter Attila Gergely, Balázs Murnyák, János Bencze, Andrea Kurucz, Timea Varjas, Katalin Gombos, Tibor Hortobágyi
Dátum:	2019
ISSN:	2314-6133 2314-6141
Megjegyzések:	Tyrosine kinases play crucial roles in cellular development and tumorigenesis. Tyrosine kinase inhibitors (TKIs) are effective and widely-used drug molecules in targeted cancer therapies. Altered expressions of proto-oncogenes and tumor suppressor genes after DMBA (7,12- dimethylbenz[a]anthracene) treatment have been described as early markers of tumor induction, however their tissue-specific effects remain still unclear. Our study was aimed to examine the short-term possible anti-neoplastic and chemo-preventive effects of a TKI compound (imatinib mesylate) on a DMBA-induced mouse tumor model. In addition, we also investigated the tissue specific expressions of Hras, Kras, Myc, Trp53 genes in the brain, bone marrow, spleen, liver, abdominal lymph nodes, thymus, lungs and kidneys, respectively. 24 hours after the imatinib mesylate injection, we observed significant Kras down-regulations in the bone marrow and lung of the DMBA-treated mice. Moreover, the mRNA expression of Myc was also found to be decreased significantly in the spleen. Interestingly, while Trp53 expression was significantly increased in the lung, it was decreased in the other tissues. However, there was also a tendency in the decreased Myc level in the bone marrow, brain, kidneys, lungs, lymph nodes, and in the decreased Hras level in the bone marrow, kidneys and lungs, although no significant differences were observed. Our findings indicate rapid tissue-specific impact of imatinib mesylate on DMBA-induced gene expression in vivo, supporting the chemo-preventive potential of imatinib mesylate in cancer.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	BioMed Research International. - 2019 (2019), p. 1-12. -
További szerzők:	Murnyák Balázs (1986-) (molekuláris biológus, genetikus) Bencze János (1991-) (orvos) Kurucz Andrea (1984-) (orvos) Varjas Tímea Gombos Katalin Hortobágyi Tibor (1965-) (patológus)
Pályázati támogatás:	2017-1.2.1-NKP-2017-00002 Egyéb UNKP-18-3 Egyéb EFOP-3.6.3-VEKOP-16-2017-00009 EFOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM059449
Első szerző:	Szepesi Rita (neurológus)
Cím:	New prognostic score for the prediction of 30-day outcome in spontaneous supratentorial cerebral haemorrhage / Rita Szepesi, Ibolya Katalin Széll, Tibor Hortobágyi, László Kardos, Katalin Nagy, Levente István Lánczi, Ervin Berényi, Dániel Bereczki, László Csiba
Dátum:	2015
ISSN:	2314-6133 2314-6141
Megjegyzések:	Aims. The purpose of the present study was to evaluate predictors of outcome in primary supratentorial cerebral haemorrhage. Furthermore, we aimed to develop a prognostic model to predict 30-day fatality. Methods. We retrospectively analyzed a database of 156 patients with spontaneous supratentorial haemorrhage to explore the relationship between clinical and CT characteristics and fatal outcome within 30 days using multiple logistic regression analysis. The analyzed factors included volumetric data assessed by neuropathological and CT volumetry. A second CT scan in survivors or neuropathological ABC/2 volumetry in nonsurvivors was used along with the baseline CT to assess the growth index of haematoma. Results. Systolic blood pressure, serum potassium and glucose levels, platelet count, absolute and relative haematoma volumes, and presence and size of intraventricular haemorrhage statistically significantly predicted the fatal outcome within 30 days. Based on our results we formulated a six-factor scoring algorithm named SUSPEKT to predict outcome. Conclusions. After validation the SUSPEKT score may be applicable in general clinical practice for early patient selection to optimize individual management or for assessment of eligibility for treatment trials.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban SPONTANEOUS INTRACEREBRAL HEMORRHAGE ABC/2 ESTIMATION TECHNIQUE RISK-FACTORS ALCOHOL-CONSUMPTION ISCHEMIC-STROKE GRADING SCALE MORTALITY VOLUME GUIDELINES SURVIVAL
Megjelenés:	Biomed Research International 2015 : 961085 (2015), p. 1-8. -
További szerzők:	Széll Ibolya Hortobágyi Tibor (1965-) (patológus) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Nagy Katalin Lánczi Levente (1990-) (általános orvos) Berényi Ervin (1964-) (radiológus) Bereczki Dániel (1960-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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