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001-es BibID:	BIBFORM077465
Első szerző:	Clemens Béla (neurológus)
Cím:	Inter-ictal network of focal epilepsy and effects of clinical factors on network activity / Béla Clemens, Johanna Dömötör, Miklós Emri, Szilvia Puskás, István Fekete
Dátum:	2019
ISSN:	1388-2457
Megjegyzések:	OBJECTIVE: Aim of the study was to explore the inter-ictal, resting-state EEG network in patients with focal epilepsy (FE) and to specify clinical factors that influence network activity. METHODS: Functional EEG connectivity (EEGfC) differences were computed between 232 FE patients (FE group) and 77 healthy controls. EEGfC was computed among 23 cortical regions within each hemisphere, for 25 very narrow bands from 1 to 25?Hz. We computed independent effects for six clinical factors on EEGfC in the FE group, by ANOVA and post-hoc t-statistics, corrected for multiple comparisons by false discovery rate method. RESULTS: Robust, statistically significant EEGfC differences emerged between the FE and the healthy control groups. Etiology, seizure type, duration of the illness and antiepileptic treatment were independent factors that influenced EEGfC. Statistically significant results occurred selectively in one or a few very narrow bands and outlined networks. Most abnormal EEGfC findings occurred at frequencies that mediate integrative and motor activities. CONCLUSIONS: FE patients have abnormal resting-state EEGfC network activity. Clinical factors significantly modify EEGfC. SIGNIFICANCE: Delineation of the FE network and modifying factors can open the way for targeted investigations and introduction of EEGfC into epilepsy research and practice.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban EEG functional connectivity Epileptic network Focal epilepsy LORETA Source Correlation
Megjelenés:	Clinical Neurophysiology. - 130 : 2 (2019), p. 251-258. -
További szerzők:	Dömötör Johanna (1982-) (neurológus) Emri Miklós (1962-) (fizikus) Puskás Szilvia (1979-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter)
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001-es BibID:	BIBFORM057414
Első szerző:	Clemens Béla (neurológus)
Cím:	Lamotrigine decreases EEG synchronization in a use-dependent manner in patients with idiopathic generalized epilepsy / B. Clemens, P. Piros, M. Bessenyei, K. Hollódy
Dátum:	2007
ISSN:	1388-2457
Megjegyzések:	Objective: To investigate the quantitative EEG effects of lamotrigine (LTG) monotherapy. Hypothesis: LTG was predicted to decrease thalamo-cortical neuronal synchronization in idiopathic generalized epilepsy (IGE).Methods: Waking EEG background activity of 19 IGE patients was investigated before treatment and in the course of LTG monotherapy.Raw absolute power (RAP), raw percent power (RRP), and raw mean frequency (RMF) were computed for 19 electrodes and four frequency bands (delta = 1.5?3.5 Hz, theta = 3.5?7.5 Hz, alpha = 7.5?12.5 Hz, and beta = 12.5?25.0 Hz). Inter- and intrahemispheric coherence was computed for eight electrode pairs and the four frequency bands. In addition, scalp-averages were calculated for each variable. Group differences were computed by means of nonparametric statistics including correction for multiple comparisons.Results: Main results were decreased delta and theta RAP (p < 0.05 for scalp-averages). LTG compressed the delta, theta, and alpha RAP datasets, reducing the upper limit of the scatter in particular. Spearman r-values indicated marked correlation between the starting values (RAPuntreated) and the LTG-related decrease (RAPtreated RAPuntreated) in three bands: delta (r = 0.72; p = 0.0005), theta (r = 0.59; p = 0.007), and alpha (r = 0.61; p = 0.006). Thus, the greater the baseline neuronal synchronization, the marked the dampening effect of LTG on it. The remaining findings were decreased theta RRP, theta RMF, and increased alpha RMF (p < 0.05 for scalp-averages).The electrode-related changes were small but topographically consistent across the 19 electrode sites. LTG did not affect coherence.Conclusions: 1. LTG partially normalized the spectral composition of EEG background activity. LTG decreased pathological thalamocortical synchronization in use-dependent manner. 2. LTG did not cause quantitative EEG alterations suggesting worsening of the physiological brain functions. Instead, its profile suggested a mild psychostimulant effect.Significance: The results contribute to the understanding of the effect of LTG at the network level.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Lamotrigine Quantitative EEG Idiopathic generalized epilepsy
Megjelenés:	Clinical Neurophysiology. - 118 : 4 (2007), p. 910-917. -
További szerzők:	Piros Pálma (1969-) (neurológus) Bessenyei Mónika (1970-) (neurológus, csecsemő- és gyermekgyógyász) Hollódy Katalin (1955-) (csecsemő- és gyermekgyógyász)
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001-es BibID:	BIBFORM012784
Első szerző:	Clemens Béla (neurológus)
Cím:	Theta EEG source localization using LORETA in partial epilepsy patients with and without medication? / Clemens Béla, Bessenyei Mónika, Fekete István, Puskás Szilvia, Kondákor István, Tóth Márton, Hollódy Katalin
Dátum:	2010
ISSN:	1388-2457
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Clinical Neurophysiology. - 121 : 6 (2010), p. 848-858. -
További szerzők:	Bessenyei Mónika (1970-) (neurológus, csecsemő- és gyermekgyógyász) Fekete István (1951-) (neurológus, pszichiáter) Puskás Szilvia (1979-) (neurológus) Kondákor István Tóth Márton (1960-) (neurológus) Hollódy Katalin (1955-) (csecsemő- és gyermekgyógyász)
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