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1.

001-es BibID:BIBFORM015651
Első szerző:Czuriga-Kovács Katalin Réka (neurológus)
Cím:Cerebro- and cardiovascular reactivity and neuropsychological performance in hypertensive patients / Katalin Réka Kovács, Csilla Cecília Szekeres, Zoltán Bajkó, Krisztina Csapó, Sándor Molnár, László Oláh, Mária Tünde Magyar, Dániel Bereczki, László Kardos, Pál Soltész, Andrea Burainé Bojtor, László Csiba
Dátum:2010
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of the Neurological Sciences. - 299 : 1-2 (2010), p. 120-125. -
További szerzők:Szekeres Csilla Cecília (1980-) (orvos) Bajkó Zoltán (1970-) (neurológus) Csapó Krisztina (1979-) (neurológus) Molnár Sándor (1973-) (neurológus) Oláh László (1967-) (neurológus) Magyar Mária Tünde (1970-) (neurológus) Bereczki Dániel (1960-) (neurológus) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Soltész Pál (1961-) (belgyógyász, kardiológus) Burainé Bojtor Andrea Csiba László (1952-) (neurológus, pszichiáter)
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2.

001-es BibID:BIBFORM029163
Első szerző:Orosz László (sebész)
Cím:Clinical applicability of a mathematical model in assessing the functional ability of the communicating arteries of the circle of Willis / László Orosz, Arjan W. Hoksbergen, Csilla Molnár, Péter Siró, Francis Cassot, Jean-Pierre Marc-Vergnes, Béla Fülesdi
Dátum:2009
Megjegyzések:The brain collateral blood supply, which is essential in patients suffering from significant stenoses or occlusions of the extracranial arteries, remains difficult to assess accurately in practice. We compared data obtained from transcranial color-coded duplex sonography (TCCD) combined with carotid compression tests to morphometric autopsy data and to results given by a mathematical model of the cerebral macrocirculation. METHODS AND RESULTS: In 16 moribund patients, anterior and posterior communicating arteries of the circle of Willis were divided into functional and non-functional based on the results of the TCCD combined with carotid compression tests. After death of the patients diameters and lengths of the main intracranial arteries were measured at autopsy and these values were treated with a mathematical model for calculating blood flow and blood pressure in all the segments of the arterial network. The diameters and the blood flows through the communicating arteries were found to be significantly higher in the group of functional arteries than in that of non-functional ones. However, blood flow was also shown to be dependent on other parameters such as the pressure difference between the two ends of the vessel. CONCLUSION: Our data indicate that functional ability of the Willisian collaterals depends on morphological and functional parameters, and is therefore better assessed by a functional method, such as TCCD, than by a solely morphological one, such as cerebral angiography. Mathematically based circulation modeling, when it will be possible, could be a more comprehensive tool for delineating patients at a higher risk for hemodynamic cerebrovascular insufficiency.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of the Neurological Sciences. - 287 : 1-2 (2009), p. 94-99. -
További szerzők:Hoksbergen, Arjan W. J. Molnár Csilla (1962-) (aneszteziológus) Siró Péter (1973-) (neurológus, aneszteziológus, intenzív terápiás szakorvos) Cassot, Francis Marc-Vergnes, Jean-Pierre Fülesdi Béla (1961-) (aneszteziológus)
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3.

001-es BibID:BIBFORM049332
035-os BibID:PMID:24262992
Első szerző:Szabó Katalin Judit (neurológus)
Cím:Effect of non-steroid anti-inflammatory drugs on neurovascular coupling in humans / Katalin Szabo, Bernhard Rosengarten, Tunde Juhasz, Eva Lako, Laszlo Csiba, Laszlo Olah
Dátum:2014
ISSN:0022-510X
Megjegyzések:BACKGROUND/AIMS: Neuronal activation induced cerebral blood flow increase was shown in animal experiments to require the presence of functioning cyclooxygenase. Our aim was to study whether widely used, non-steroid anti-inflammatory drugs (NSAIDs), given orally in usual therapeutic doses, inhibit neurovascular coupling in humans. METHODS: By using a visual cortex stimulation paradigm, the flow velocity response was measured by transcranial Doppler sonography in both posterior cerebral arteries of fifteen young healthy adults. The investigation was repeated in the same subjects after 2-day administration of 3x25mg indomethacin (indomethacin phase) and 2x550mg naproxen (naproxen phase). Visual-evoked-potentials were also recorded during the control phase and after administration of NSAIDs. RESULTS: Basal flow velocity significantly decreased while the pulsatility index increased after administration of either indomethacin or naproxen (p<0.01). Despite unchanged visual-evoked-potentials, the visually evoked flow velocity increase (26±7% in the control phase) significantly declined after administration of indomethacin (19±5%; p<0.01) or naproxen (20±5%; p<0.02). CONCLUSION: Oral administration of indomethacin or naproxen in their usual therapeutic doses significantly impaired the resting and the visually evoked blood flow regulations in healthy human subjects. Together with stable evoked potentials, our findings indicate disturbance of neurovascular coupling.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cerebral blood flow
Cerebral vasoconstriction
Neurovascular coupling
Non-steroid anti-inflammatory drugs
Transcranial Doppler
Visual stimulation
Megjelenés:Journal of the Neurological Sciences. - 336 : 1-2 (2014), p. 227-231. -
További szerzők:Rosengarten, Bernhard Juhász Tünde Lakó Éva Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
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4.

001-es BibID:BIBFORM020679
Első szerző:Szabó Katalin Judit (neurológus)
Cím:Hypocapnia induced vasoconstriction significantly inhibits the neurovascular coupling in humans / Szabo K., Lako E., Juhasz T., Rosengarten B., Csiba L., Olah L.
Dátum:2011
ISSN:0022-510X
Megjegyzések:Previous studies proved that vasodilation, caused by hypercapnia or acetazolamide, does not inhibit the visually evoked flow velocity changes in the posterior cerebral arteries. Our aim was to determine whether vasoconstriction induced by hypocapnia affects the neurovascular coupling. METHODS: By using a visual cortex stimulation paradigm, visually evoked flow velocity changes were detected by transcranial Doppler sonography in both posterior cerebral arteries of fourteen young healthy adults. The control measurement was followed by the examination under hyperventilation. Visual-evoked-potentials were also recorded during the control and hyperventilation phases. RESULTS: The breathing frequency increased from 16 ± 2 to 37 ± 3/min during hyperventilation, resulting in a decrease of the end-tidal CO(2) from 37 ± 3 to 25 ± 3 mm Hg and decrease of resting peak systolic flow velocity from 58 ± 11 to 48 ± 11 cm/s (p<0.01). To allow comparisons between volunteers, relative flow velocity was calculated in relation to baseline. Repeated measures analysis of variance revealed significant difference between the relative flow velocity time courses during hyper- and normoventilation (p<0.001). The maximum changes of visually evoked relative flow velocities were 26 ± 7% and 12 ± 5% during normoventilation and hyperventilation, respectively (p<0.01). Visual-evoked-potentials did not differ in the control and hyperventilation phases. CONCLUSION: The significantly lower visually evoked flow velocity changes but preserved visual-evoked-potential during hyperventilation indicates that the hypocapnia induced vasoconstriction significantly inhibits the neuronal activity evoked flow response.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of The Neurological Sciences. - 309 : 1-2 (2011), p. 58-62. -
További szerzők:Lakó Éva Juhász Tünde Rosengarten, Bernhard Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
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5.

001-es BibID:BIBFORM065094
Első szerző:Viski Sándor Zsolt (orvos)
Cím:The acute effects of alcohol on cerebral hemodynamic changes induced by the head-up tilt test in healthy subjects / Sandor Viski, Miklos Orosz, Katalin Reka Czuriga-Kovacs, Maria Tunde Magyar, Laszlo Csiba, Laszlo Olah
Dátum:2016
ISSN:0022-510X
Megjegyzések:Background: Alcohol is a known triggering factor for orthostatic dysfunction, increasing the risk of neurally-mediated syncope. Since orthostatic tolerance may be affected by both systemic and cerebral hemodynamic changes, our aim was to investigate the acute effects of alcohol on cerebral vasoreactivity measured during the head-up tilt (HUT) test in 20 healthy subjects.Methods: Mean arterial blood pressure (mBP), heart rate, and flow parameters in both middle cerebral arteries (MCAs) were continuously recorded in the supine and during a 10-minute HUT positions before and after alcohol intake.Results: The HUT test resulted in a more prominent decline of adjusted mBP at the level of MCAs (mBPMCA) and a significantly larger decrease of MCA mean flow velocities (MFVMCA) in the post-alcohol period than before alcohol intake. During the HUT phase, the relative decrease in MFVMCA was significantly smaller than the reduction in mBPMCA before drinking alcohol, while these changes were similar after alcohol ingestion. The cerebrovascular resistance index (CVRi) decreased during the HUT phase in the control period, however, it increased after alcohol intake.Conclusion: The similar decrease inmBPMCA and MFVMCA during orthostatic stress after alcohol ingestion together with the increased CVRi indicated the impairment of the compensatory vasodilation of cerebral resistance vessels, i.e. impaired cerebral autoregulation. These findings suggest that alcohol may contribute to impaired orthostatic tolerance not only by a hypotensive response but also by the alteration of cerebral blood flow regulation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Alcohol
Orthostatic stress
Head-up tilt test
Cerebral blood flow
Cerebral autoregulation
Baroreceptor reflex
Transcranial doppler
Megjelenés:Journal Of The Neurological Sciences 368 (2016), p. 113-120. -
További szerzők:Orosz Miklós Czuriga-Kovács Katalin Réka (1981-) (neurológus) Magyar Mária Tünde (1970-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:NAP_13-1-2013-0001
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6.

001-es BibID:BIBFORM063682
Első szerző:Viski Sándor Zsolt (orvos)
Cím:Effect of reading on blood flow changes in the posterior cerebral artery in early blind and sighted people : a transcranial Doppler study / Sandor Viski, David Orgovan, Katalin Szabo, Bernhard Rosengarten, Laszlo Csiba, Laszlo Olah
Dátum:2016
ISSN:0022-510X
Megjegyzések:BackgroundNeuroimaging studies proved that Braille reading resulted in visual cortex activation in blind people, however, very few data are available about the measure of flow increase in these subjects. Therefore, we investigated the flow response in the posterior cerebral artery (PCA) of eleven early blind and ten sighted subjects induced by reading Braille and print, respectively.MethodsTwo experimental protocols were used in both groups: PCA flow velocity during reading was compared to the resting phase and "NLC" phase (volunteers "read" non-lexical characters; e.g. .,-.:,-.:...,). The use of these experimental protocols allowed to investigate separately the effect of "light stimulus + print reading" versus "print reading alone" in sighted, and "hand/finger movement + Braille reading" versus "Braille reading alone" in blind subjects.ResultsThe flow response in the PCA evoked by "Braille reading alone" in blind (10.5 ? 4.5%) and "print reading alone" in sighted subjects (8.1 ? 3.5%) was similar. The flow increase induced by "hand/finger movement + Braille reading" and by "Braille reading alone" did not differ in blind people, however, "light stimulus + print reading" in sighted subjects caused higher PCA flow increase (25.9 ? 6.9%) than "print reading alone" (8.1 ? 3.5%).ConclusionThe similar PCA flow response induced by Braille and print reading alone suggested a similar degree of occipital cortex activation in blind and sighted subjects. In sighted people, the 3-times higher flow velocity increase induced by "light stimulus + print reading" compared with "print reading alone" indicated that 2/3 of PCA flow increase during reading was due to the light stimulus and only 1/3 of flow response was caused by reading alone.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Cortical activation
Blind subjects
Cerebral blood flow
Neurovascular coupling
Transcranial Doppler
Megjelenés:Journal Of The Neurological Sciences 363 (2016), p. 132-139. -
További szerzők:Orgovan, David Szabó Katalin Judit (1984-) (neurológus) Rosengarten, Bernhard Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
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