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001-es BibID:	BIBFORM029093
Első szerző:	Birinyi András (anatómus, neurobiológus)
Cím:	Synaptic targets of commissural interneurons in the lumbar spinal cord of neonatal rats / Birinyi A., Viszokay K., Wéber I., Kiehn O., Antal M.
Dátum:	2003
ISSN:	0021-9967
Megjegyzések:	There is strong evidence that commissural interneurons, neurons with axons that extend to the contralateral side of the spinal cord, play an important role in the coordination of left/right alternation during locomotion. In this study we investigated the projections of commissural interneurons to motor neurons and other commissural interneurons on the other side of the spinal cord in neonatal rats. To establish whether there are direct contacts between axons of commissural interneurons and motor neurons, we carried out two series of experiments. In the first experiment we injected biotinylated dextran amine (BDA) into the lateral motor column to retrogradely label commissural interneurons that may have direct projections to motor neurons. Stained neurons were recovered in the ventromedial areas of the contralateral gray matter in substantial numbers. In the second experiment BDA was injected into the ventromedial gray matter on one side of the lumbar spinal cord, whereas motor neurons were simultaneously labeled on the opposite side by applying biocytin onto the ventral roots. BDA injections into the ventromedial gray matter labeled a strong axon bundle that arose from the site of injection, crossed the midline in the ventral commissure, and extensively arborized in the contralateral ventral gray matter. Many of these axons made close appositions with dendrites and somata of motor neurons and also with commissural interneurons retrogradely labeled with BDA. The results suggest that commissural interneurons may establish monosynaptic contacts with motor neurons on the opposite side of the spinal cord. Our findings also indicate that direct reciprocal connections between commissural interneurons on the two sides of the spinal cord may also exist.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok magyar nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Comparative Neurology. - 461 : 4 (2003), p. 429-440. -
További szerzők:	Viszokay Kornél Wéber Ildikó (1972-) (biológus, neurobiológus) Kiehn, Ole Antal Miklós (1951-) (orvos, anatómus)
Pályázati támogatás:	046121 OTKA
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM098800
035-os BibID:	(WoS)000687051800001 (Scopus)85112773766
Első szerző:	De Oliveira Miranda, Camila (PhD hallgató)
Cím:	Morphological and neurochemical characterization of glycinergic neurons in laminae of the mouse spinal dorsal horn / Miranda Camila Oliveira, Hegedüs Krisztina, Wildner Hendrik, Zeilhofer Hanns Ulrich, Antal Miklós
Dátum:	2022
ISSN:	0021-9967
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of Comparative Neurology. - 530 : 3 (2022), p. 607-626. -
További szerzők:	Hegedűs Krisztina Wildner, Hendrik Zeilhofer, Hanns Ulrich Antal Miklós (1951-) (orvos, anatómus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM040623
Első szerző:	Szűcs Péter (kutatóorvos)
Cím:	Axon diversity of lamina I local-circuit neurons in the lumbar spinal / Szucs Peter, Luz Liliana, Pinho Raquel, Aguiar Paulo, Antal Zsofia, Tiong Sheena, Todd Andrew J., Safronov Boris
Dátum:	2013
Megjegyzések:	Spinal lamina I is a key area for relaying and integrating information from nociceptive primary afferents with various other sources of inputs. While lamina I projection neurons have been intensively studied, much less attention has been given to local-circuit neurons (LCNs), which form the majority of the lamina I neuronal population. In this work the infrared light-emitting diode (IR-LED) oblique illumination technique was used to visualize and label LCNs, allowing reconstruction and analysis of their dendritic and extensive axonal trees. We show that the majority of lamina I neurons with locally branching axons fall into the multipolar (with ventrally protruding dendrites) and flattened (dendrites limited to lamina I) somatodendritic categories. Analysis of their axons revealed that the initial myelinated part gives rise to several unmyelinated small-diameter branches that have a high number of densely packed large varicosities and an extensive rostrocaudal (2-3 segments), mediolateral and dorsoventral (reaching laminae III-IV) distribution. The extent of the axon and the occasional presence of long solitary branches suggest that LCNs may also form short and long propriospinal connections. We also found that the distribution of axon varicosities and terminal field locations show substantial heterogeneity and that a substantial portion of LCNs is inhibitory. Our observations indicate that LCNs of lamina I form intersegmental as well as interlaminar connections and may govern large numbers of neurons, providing anatomical substrate for rostrocaudal "processing units" in the dorsal horn.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Comparative Neurology. - 521 : 12 (2013), p. 2719-2741. -
További szerzők:	Luz, Liliana L. Pinho, Raquel Aguiar, Paulo Antal Zsófia (1985-) (orvos) Tiong, Sheena Todd, Andrew J. Safronov, Boris V.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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