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001-es BibID:	BIBFORM063055
Első szerző:	Gonda Sándor (gyógyszerész)
Cím:	Effects of N source concentration and NH4+/NO3- ratio on phenylethanoid glycoside pattern in tissue cultures of Plantago lanceolata L.: A metabolomics driven full-factorial experiment with LC-ESI-MS3 / Sándor Gonda, Attila Kiss-Szikszai, Zsolt Szűcs, Csaba Máthé, Gábor Vasas
Dátum:	2014
ISSN:	0031-9422
Megjegyzések:	Tissue cultures of a medicinal plant, Plantago lanceolata L. were screened for phenylethanoid glycosides (PGs) and other natural products (NPs) with LC?ESI?MS 3 . The effects of N source concentration and NH + 4 /NO 3 ratio were evaluated in a full-factorial (FF) experiment. N concentrations of 10, 20, 40 and 60 mM, and NH + 4 /NO 3 ratios of 0, 0.11, 0.20 and 0.33 (ratio of NH + 4 in total N source) were tested. Several peaks could be identified as PGs, of which, 16 could be putatively identified from the MS/MS/MS spectra. N source concentration and NH4+ /NO3- ratio had significant effects on the metabolome, their effects on individual PGs were different despite these metabolites were of the same biosynthethic class. Chief PGs were plantamajoside and acteoside (verbascoside), their highest concentrations were 3.54 ? 0.83% and 1.30 ? 0.40% of dry weight, on media 10(0.33) and 40(0.33), respectively. NH4+ /NO3- ratio and N source concentration effects were examined on a set of 89 NPs. For most NPs, high increases in abundance were observed compared to Murashige?Skoog medium. Abundances of 42 and 10 NPs were significantly influenced by the N source concentration and the NH + 4 /NO 3 ratio, respectively. Optimal media for production of different NP clusters were 10(0), 10(0.11) and 40(0.33). Interaction was observed between NH + 4 /NO 3 ratio and N source concentration for many NPs. It was shown in simulated experiments, that one-factor at a time (OFAT) experimental designs lead to sub-optimal media compositions for production of many NPs, and alternative experimental designs (e.g. FF) should be preferred when optimizing medium N source for optimal yield of NPs. If using OFAT, the N source concentration is to be optimized first, followed by NH4+/NO3- ratio, as this reduces the likeliness of suboptimal yield results.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Phenylpropanoid glycosides Polyphenolic substances Phenoloid secondary metabolites Data-mining Design of experiments Medicinal plant tissue culture Omics Ammonium Nitrate
Megjelenés:	Phytochemistry. - 106 (2014), p. 44-54. -
További szerzők:	Kiss-Szikszai Attila (1975-) (vegyész) Szűcs Zsolt (1990-) (gyógyszerész) Máthé Csaba (1966-) (biológus) Vasas Gábor (1975-) (biológus-vegyész)
Pályázati támogatás:	PD 112374 OTKA K 81370 OTKA 4.2.2.A-11/1/KONV-2012-0043 TÁMOP 4.2.1/B-09/1/KONV-2010-0007 TÁMOP 4.2.4. A/2-11-1-2012-0001 TÁMOP
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001-es BibID:	BIBFORM102050
035-os BibID:	(cikkazonosító)113245 (WoS)001011421000004 (Scopus)85131404362
Első szerző:	Plaszkó Tamás (Biológus Msc)
Cím:	Interactions of fungi with non-isothiocyanate products of the plant glucosinolate pathway: A review on product formation, antifungal activity, mode of action and biotransformation / Plaszkó, Tamás, Szűcs Zsolt, Vasas Gábor, Gonda Sándor
Dátum:	2022
ISSN:	0031-9422
Megjegyzések:	The glucosinolate pathway, which is present in the order Brassicales, is one of the most researched defensive natural product biosynthesis pathways. Its core molecules, the glucosinolates are broken down upon pathogen challenge or tissue damage to yield an array of natural products that may help plants defend against the stressor. Though the most widely known glucosinolate decomposition products are the antimicrobial isothiocyanates, there is a wide range of other volatile and non-volatile natural products that arise from this biosynthetic pathway. This review summarizes our current knowledge on the interaction of these much less examined, non-isothiocyanate products with fungi. It deals with compounds including (1) glucosinolates and their biosynthesis precursors; (2) glucosinolate-derived nitriles (e.g. derivatives of 1H-indol-3-acetonitrile), thiocyanates, epithionitriles and oxazolidine-2-thiones; (3) putative isothiocyanate downstream products such as raphanusamic acid, 1H-indol-3-methanol (= indole-3-carbinol) and its oligomers, 1H-indol-3-ylmethanamine and ascorbigen; (4) 1H-indol-3-acetonitrile downstream products such as 1H-indole-3-carbaldehyde (indole-3-carboxaldehyde), 1H-indole-3-carboxylic acid and their derivatives; and (5) indole phytoalexins including brassinin, cyclobrassinin and brassilexin. Herein, a literature review on the following aspects is provided: their direct antifungal activity and the proposed mechanisms of antifungal action, increased biosynthesis after fungal challenge, as well as data on their biotransformation / detoxification by fungi, including but not limited to fungal myrosinase activity.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk plant pathogenic fungi plant-microbe interactions fungal metabolism glucosinolates Cruciferae
Megjelenés:	Phytochemistry. - 200 (2022), p. 1-33. -
További szerzők:	Szűcs Zsolt (1990-) (gyógyszerész) Vasas Gábor (1975-) (biológus-vegyész) Gonda Sándor (1984-) (gyógyszerész)
Pályázati támogatás:	OTKA-128021 OTKA EFOP-3.6.1-16-2016-00022 EFOP
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