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001-es BibID:	BIBFORM071957
035-os BibID:	(cikkazonosító)151 (WoS)000423697600001 (Scopus)85041621018
Első szerző:	Hornyák Lilla
Cím:	The role of indoleamine-2,3-dioxygenase (IDO) in cancer development, diagnostics, and therapy / Lilla Hornyák, Nikoletta Dobos, Gábor Koncz, Zsolt Karányi, Dénes Páll, Zoltán Szabó, Gábor Halmos, Lóránt Székvölgyi
Dátum:	2018
ISSN:	1664-3224
Megjegyzések:	Tumors are composed of abnormally transformed cell types and tissues that differ from normal tissues in their genetic and epigenetic makeup, metabolism and immunology. Molecular compounds that modulate the immune response against neoplasms offer promising new strategies to combat cancer. Inhibitors targeting the indoleamine-2,3-dioxygenase 1 enzyme (IDO1) represent one of the most potent therapeutic opportunities to inhibit tumor growth. Herein we assess the biochemical role of IDO1 in tumor metabolism and immune surveillance, and review current diagnostic and therapeutic approaches that are intended to increase the effectiveness of immunotherapies against highly aggressive and difficult-to-treat IDO-expressing cancers.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk IDO Gene Expression Metabolism Immunotherapy immune surveillance Cancer diagnostics Clinical Trials as Topic
Megjelenés:	Frontiers in Immunology. - 9 : 151 (2018), p. 1-8. -
További szerzők:	Dobos Nikoletta (1981-) (biológus) Koncz Gábor (1970-) (biológus, immunológus) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Páll Dénes (1967-) (belgyógyász, kardiológus) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Halmos Gábor (1962-) (gyógyszerész, receptorfarmakológus, experimentális onkológus) Székvölgyi Lóránt (1977-) (biofizikus, biokémikus, sejtbiológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00024 GINOP NKFIH-ERC-HU-117670 NKFIH
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL DOI
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001-es BibID:	BIBFORM069444
035-os BibID:	(cikkazonosító)689 (WoS)000403397100001 (Scopus)85021185202
Első szerző:	Qin, Yong
Cím:	Cervical cancer neoantigen landscape and immune activity is associated with HPV master regulators / Yong Qin, Suhendan Ekmekcioglu, Marie-Andrée Forget, Lorant Szekvolgyi, Patrick Hwu, Elizabeth A. Grimm, Amir A. Jazaeri, Jason Roszik
Dátum:	2017
ISSN:	1664-3224
Megjegyzések:	Human papillomaviruses (HPVs) play a major role in development of cervical cancer, and HPV oncoproteins are being targeted by immunotherapies. Although these treatments show promising results in the clinic, many patients do not benefit or the durability is limited. In addition to HPV antigens, neoantigens derived from somatic mutations may also generate an effective immune response, and represent an additional and distinct immunotherapy strategy against this and other HPV-associated cancers. To explore the landscape of neoantigens in cervix cancer, we predicted all possible mutated neopeptides in two large sequencing data sets, and analyzed whether mutation and neoantigen load correlate with antigen presentation, infiltrating immune cell types, and a HPV-induced master regulator gene expression signature. We found that targetable neoantigens are detected in most tumors, and there are recurrent mutated peptides from known oncogenic driver genes (KRAS, MAPK1, PIK3CA, ERBB2, and ERBB3) that are predicted to be potentially immunogenic. Our studies show that HPV-induced master regulators are not only associated with HPV load, but may also play crucial roles in relation to mutation and neoantigen load, and also the immune microenvironment of the tumor. A subset of these HPV-induced master regulators positively correlated with expression of immune-suppressor molecules such as PD-L1, TGFB1, and IL-10 suggesting they may be involved in abrogating anti-tumor response induced by the presence of mutations and neoantigens. Based on these results, we predict that HPV master regulators identified in our study might be potentially effective targets in cervical cancer.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Immunology. - 8 (2017), p. 1-8. -
További szerzők:	Ekmekcioglu, Suhendan Forget, Marie-Andrée Székvölgyi Lóránt (1977-) (biofizikus, biokémikus, sejtbiológus) Hwu, Patrick Grimm, Elizabeth A. Jazaeri, Amir A. Roszik, Jason
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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