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001-es BibID:	BIBFORM111406
035-os BibID:	(cikkazonosító)7449 (Scopus)85158154745 (WoS)001001538500018
Első szerző:	Boutry, Justine
Cím:	Spontaneously occurring tumors in different wild-derived strains of hydra / Justine Boutry, Marie Buysse, SophieTissot, Chantal Cazevielle, Rodrigo Hamede, Antoine M. Dujon, Beata Ujvari, Mathieu Giraudeau, Alexander Klimovich, Frédéric Thomas, Jácint Tökölyi
Dátum:	2023
ISSN:	2045-2322
Megjegyzések:	Hydras are freshwater cnidarians widely used as a biological model to study diferent questions such as senescence or phenotypic plasticity but also tumoral development. The spontaneous tumors found in these organisms have been so far described in two female lab strains domesticated years ago (Hydra oligactis and Pelmatohydra robusta) and the extent to which these tumors can be representative of tumors within the diversity of wild hydras is completely unknown. In this study, we examined individuals isolated from recently sampled wild strains of diferent sex and geographical origin, which have developed outgrowths looking like tumors. These tumefactions have common features with the tumors previously described in lab strains: are composed of an accumulation of abnormal cells, resulting in a similar enlargement of the tissue layers. However, we also found diversity within these new types of tumors. Indeed, not only females, but also males seem prone to form these tumors. Finally, the microbiota associated to these tumors is diferent from the one involved in the previous lineages exhibiting tumors. We found that tumorous individuals hosted yet undescribed Chlamydiales vacuoles. This study brings new insights into the understanding of tumor susceptibility and diversity in brown hydras from diferent origins.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 13 : 1 (2023), p. 1-11. -
További szerzők:	Buysse, Marie Tissot, Sophie Cazevielle, Chantal Hamede, Rodrigo Dujon, Antoine M. Ujvári Beáta Giraudeau, Mathieu Klimovich, Alexander Thomas, Frédéric Tökölyi Jácint (1984-) (biológus)
Pályázati támogatás:	MTA-DE Lendület LP2021/12. MTA Élettudományok - Biológiai tudományok
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM117690
035-os BibID:	(cikkazonosító)22819 (Scopus)85180166441
Első szerző:	Tissot, Sophie
Cím:	Author Correction : The impact of food availability on tumorigenesis is evolutionarily conserved / Sophie Tissot, Lena Guimard, Jordan Meliani, Justine Boutry, Antoine M. Dujon, Jean?Pascal Capp, Jácint Tökölyi, Peter A. Biro, Christa Beckmann, Laura Fontenille, Nam Do Khoa, Rodrigo Hamede, Benjamin Roche, Beata Ujvari, Aurora M. Nedelcu, Frédéric Thomas
Dátum:	2023
ISSN:	2045-2322
Megjegyzések:	Correction to: Scientific Reports, published online 14 November 2023 The original version of this Article contained an error in the Funding section. "This work was funded by the MAVA Foundation, HOFFMANN Family, and by the following grant: EVOSEXCAN project (ANR-23-CE13-0007)." now reads: "This work was funded by the CNRS, the MAVA Foundation, the HOFFMANN Family, and by the following grant: EVOSEXCAN project (ANR-23-CE13-0007)." The original Article has been corrected.
Tárgyszavak:	Természettudományok Biológiai tudományok hozzászólás folyóiratcikk
Megjelenés:	Scientific Reports. - 13 : 1 (2023), p. 1-8. -
További szerzők:	Guimard, Lena Meliani, Jordan Boutry, Justine Dujon, Antoine M. Capp, Jean-Pascal Tökölyi Jácint (1984-) (biológus) Bíró Péter (1947-) (biológus, ökológus, ichthyológus) Beckmann, Christa Fontenille, Laura Do Khoa, Nam Hamede, Rodrigo Roche, Benjamin Ujvári Beáta Nedelcu, Aurora M. Thomas, Frédéric
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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Saját polcon:

001-es BibID:	BIBFORM116116
035-os BibID:	(cikkazonosító)19825 (WoS)001104793000027 (Scopus)85176427014
Első szerző:	Tissot, Sophie
Cím:	The impact of food availability on tumorigenesis is evolutionarily conserved / Sophie Tissot, Lena Guimard, Jordan Meliani, Justine Boutry, Antoine M. Dujon, Jean-Pascal Capp, Jácint Tökölyi, Peter A. Biro, Christa Beckmann, Laura Fontenille, Nam Do Khoa, Rodrigo Hamede, Benjamin Roche, Beata Ujvari, Aurora M. Nedelcu, Frédéric Thomas
Dátum:	2023
ISSN:	2045-2322
Megjegyzések:	The inability to control cell proliferation results in the formation of tumors in many multicellular lineages. Nonetheless, little is known about the extent of conservation of the biological traits and ecological factors that promote or inhibit tumorigenesis across the metazoan tree. Particularly, changes in food availability have been linked to increased cancer incidence in humans, as an outcome of evolutionary mismatch. Here, we apply evolutionary oncology principles to test whether food availability, regardless of the multicellular lineage considered, has an impact on tumorigenesis. We used two phylogenetically unrelated model systems, the cnidarian Hydra oligactis and the fish Danio rerio, to investigate the impact of resource availability on tumor occurrence and progression. Individuals from healthy and tumor-prone lines were placed on four diets that differed in feeding frequency and quantity. For both models, frequent overfeeding favored tumor emergence, while lean diets appeared more protective. In terms of tumor progression, high food availability promoted it, whereas low resources controlled it, but without having a curative effect. We discuss our results in light of current ideas about the possible conservation of basic processes governing cancer in metazoans (including ancestral life history trade-offs at the cell level) and in the framework of evolutionary medicine.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 13 : 1 (2023), p. 1-13. -
További szerzők:	Guimard, Lena Meliani, Jordan Boutry, Justine Dujon, Antoine M. Capp, Jean-Pascal Tökölyi Jácint (1984-) (biológus) Bíró Péter (1947-) (biológus, ökológus, ichthyológus) Beckmann, Christa Fontenille, Laura Do Khoa, Nam Hamede, Rodrigo Roche, Benjamin Ujvári Beáta Nedelcu, Aurora M. Thomas, Frédéric
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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