Találati lista | Tudóstér

001-es BibID:	BIBFORM115852
Első szerző:	Kovács Nóra (népegészségügyi szakember)
Cím:	Exploring health service utilization among elderly populations in Hungary : A comparison of rural and urban settings in the context of Unhealthy Ageing / Kovacs N., Piko P., Kolozsvari L., Kovacs E., Ungvari Z., Adany R.
Dátum:	2023
ISSN:	1101-1262
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk
Megjelenés:	European Journal Of Public Health. - 33 : Supplement 2 (2023), p. ii69. -
További szerzők:	Pikó Péter (1987-) (biológus) Kolozsvári László Róbert (1977-) (háziorvos) Kovács Eszter (1972-) (háziorvostan szakorvos) Ungvári Zoltán Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM109992
Első szerző:	Natae, Shewaye (PhD hallgató)
Cím:	Higher VTE in a Roma population attributed to raised genetic risk and gene-environmental interaction / Natae S., Sándor J., Ádány R., Fiatal S.
Dátum:	2022
ISSN:	1101-1262
Megjegyzések:	Background: Interactions between genetic and environmental risk factors (GxE) contribute to an increased risk of venous thromboem bolism (VTE). Understanding how these factors interact provides insight for the early identification of at-risk groups within a population and creates an opportunity to apply appropriate preventive and curative measures. Objective: To estimate and compare GxE for VTE risk in the general Hungarian and Roma populations. Methods: The study was based on data extracted from a database consisting the results obtained previously in a three pillars complex health survey. DNA was genotyped for rs121909567 (SERPINC1), rs1799963 (F2), rs2036914 (F11), rs2066865 (FGG), rs6025 (F5), and rs8176719 (ABO) polymorphisms. Multivariable linear regression analysis was applied to test the impact of GxE on VTE risk. Results: Interestingly, the rs121909567 (SERPINC1) SNP was not present in the general population, however the risk allele frequency was 1.4% among Roma, which might suggest a founder effect in this minority. The risk of VTE was higher among depressive Roma subjects who carried the risk variant of rs2036914 (b = 0.819, p = 0.02); however, not for the general subjects. The joint presence of high level of LDL-C and rs2066865 increased the VTE risk only among Roma (b = 0.389, p = 0.002). A multiplicative interaction between rs8176719 and cancer was identified and higher for the Roma population (b = 0.370, p < 0.001). The VTE risk increased in the Roma population (b = 0.280, p = 0.001) but was higher in the general population (b = 0.423, p = 0.001) as a result of the multiplicative interaction between CAD and rs2036914 (F11). Conclusions: rs121909567 (SERPINC1) was confirmed as a founder mutation in the Roma population. As a result of higher genetic load and GxE interactions, the minority Roma population is at higher risk of VTE than the general Hungarian population.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk
Megjelenés:	European Journal Of Public Health. - 32 : Supplement 3 (2022), p. iii467. -
További szerzők:	Sándor János (1966-) (orvos-epidemiológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM109200
Első szerző:	Pikó Péter (biológus)
Cím:	Association of HDL subfractions with cardiovascular risk in Hungarian general and Roma populations / P. Pikó, N. A. Werissa, Z. Kosa, J. Sandor, I. Seres, G. Paragh, R. Adany
Dátum:	2022
ISSN:	1101-1262
Megjegyzések:	Background: High-density lipoprotein (HDL) cholesterol levels are inversely associated with cardiovascular risk (CVR). However, HDL cholesterol is not a homogeneous lipid and can be subdivided into subfractions, which are not uniformly associated with CVR. Among Roma populations, the prevalence of reduced HDL cholesterol levels and, consequently, that of cardiovascular diseases is very high. However, it is not known how this reduction affects the different HDL subfractions and whether changes in their representation are associated with changes in CVR. Methods: The study aimed to investigate whether there is a difference in the HDL subfraction profile between the Hungarian general (HG) and Roma populations and to determine the association of the different subfractions with the CVR estimated by the Framingham Risk Score (FRS) and the Systematic COronary Risk Evaluation (SCORE) algorithms. HDL cholesterol was separated using the Lipoprint system, which separates 10 subfractions into three classes: large HDL (HDL-L), medium HDL (HDL-I), and small HDL (HDL-S). Analyses were carried out on samples of 100 control subjects (50 Hungarian general and 50 Roma individuals with normal lipid profiles) and 277 individuals with reduced HDL-C levels. Results: Our results show that Roma has reduced levels of the overall HDL subfraction profile, with significant decreases in HDL-6, and -7. Regardless of the estimation method, elevated levels (in mmol/L) of HDL-1 to 3 and HDL-L were significantly associated with reduced risk. A higher representation (in %) of HDL-1 to 3 subfractions have a significant risk-reducing, while HDL-8 to 10 have a risk-increasing effect estimated by FRS. Conclusions: The results of our study show that levels of CVR protective HDL subfractions are significantly lower in Roma individuals and their reduced levels are associated with increased CVR, suggesting that the distribution of HDL subfractions contributes to the to the overall unfavourable CVR profile of Roma.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk
Megjelenés:	European Journal Of Public Health. - 32 : Suppl3 (2022), p. iii467. -
További szerzők:	Werissa, Nardos Abebe (1985-) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: