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001-es BibID:BIBFORM067788
Első szerző:Horváth László (gyógyszerész)
Cím:Outcome of antiepileptic drug treatment of 1282 patients with epilepsy, their pharmacovigilance reports and concomitant medication on CNS in an East-Hungarian adult database / Horváth László, Fekete Klára, Márton Sándor, Fekete István
Dátum:2016
ISSN:0022-510X
Megjegyzések:Objective: The aim of this study was to determine the outcome of antiepileptic drug (AED) treatment based on seizure freedom, pharmacovigilance reports and effects of concomitant medication on the central nervous system (CNS) of adult epileptic patients registered in the East-Hungarian Epilepsy Database.Methods: Prospective cross-sectional database was compiled from outpatient files between 1992 and 2011.Results: The majority of 1282 treated patients were on monotherapy 894 patients (70%), 286 (22%) on bitherapy and 102 (8%) on polytherapy. Of all treated patients, seizure freedom was achieved by 603 (47%). Among the seizure free patients 464 (77%) were on monotherapy, 115 (19%) on bitherapy and only 24 (4%) on polytherapy. The overall rate of adverse drug reactions (ADRs) was 16.2%. From patients on AED, 279 (22%) took concomitant drugs acting on the CNS. In a logistic regression model, other CNS-related drugs and a number of prescribed antiepileptic drugs had a significant influence on the desired outcome of seizure freedom. On comparing the Proportional Reporting Ratio and 95%CI of older and newer AEDs, no significant superiority of newer AEDs was detected.Conclusion: Careful drug selection for epileptic patients must be highlighted in order to improve outcome, reduce ADRs and improve patient compliance.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
epilepsy
database
antiepileptic drug treatment
seizure freedom
adverse drug reaction
pharmacovigilance
Megjelenés:Journal of the Neurological Sciences 369 (2016), p. 220-226. -
További szerzők:Fekete Klára (1978-) (neurológus) Márton Sándor (1965-) (matematikus) Fekete István (1951-) (neurológus, pszichiáter)
Internet cím:DOI
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